Clinical trials: Methadone, open to volunteers
Substance Use Disorders, Alcohol Use Disorder
Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic
"Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment.
- Conditions
- Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- IMPACT (NCT07232641)
- Where
- United States
- Volunteers
- 185,810 people
- Sponsor
- Boston University
Central Sleep Apnea Comorbid With Opioid Use
Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder
Patients with opioid use disorder treated with either methadone or buprenorphine are at risk of developing central sleep apnea (CSA) from these medications.
- Trial name
- NCT06521476
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sanjay R Patel
Fibroid Uterus
The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.
Currently, there is a nationwide epidemic of opioid abuse and overdose deaths. One source of excess opioids is overprescribing in the postoperative period.
- Trial name
- NCT06536517
- Testing
- Methadone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Post Operative Pain, Spinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and…
- Trial name
- MEND (NCT07222072)
- Testing
- Methadone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Opioid Use Disorder, Staff
Methadone Patient Access to Collaborative Treatment
The trial of Methadone Patient Access to Collaborative Treatment (MPACT) will establish the impact of the intervention on patient outcomes of methadone treatment retention and in treatment overdose.
- Conditions
- Opioid Use Disorder, Staff, Patients
- Trial name
- MPACT (NCT06556602)
- Testing
- MPACT
- Where
- United States
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Cleft Palate, Pain
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.
- Conditions
- Cleft Palate, Pain, Postoperative Care, Perioperative Care
- Trial name
- OPAL-Cleft (NCT06962306)
- Testing
- Methadone hydrochloride, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Opioid Use Disorder, Methadone
Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy
This pilot study will evaluate the feasibility and safety of using 1:1 tetrahydrocannabinol (THC):Cannabidiol (CBD) cannabis oil as an adjunct therapy to methadone-based Opioid Agonist Therapy (OAT) for individuals with opioid…
- Conditions
- Opioid Use Disorder, Methadone, Cannabis, Fentanyl
- Trial name
- THC-MMT (NCT05985850)
- Testing
- Aurora 1:1 Drops (Indica)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- BC Centre on Substance Use
Opioid Use Disorder
Remotely Observed Methadone Evaluation II
Methadone is an effective treatment for severe opioid use disorder (OUD), but access is limited due to the requirement of daily observed dosing by most opioid treatment programs (OTPs).
- Trial name
- ROME II (NCT06338280)
- Testing
- Sonara
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Sonara Health
EKG-QT Prolongation
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery
A number of drugs used in the perioperative period may cause prolongation of the QT interval on the electrocardiogram (EKG). These drugs include inhalational agents, antiemetic agents, pain medications, and drugs used to reverse…
- Trial name
- NCT03893734
- Testing
- methadone, Hydromorphone
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Cesarean Section Pain
Subcutaneous Methadone for Cesarean Analgesia: a Non Inferiority Study Using QoR-10
This study aims to evaluate whether subcutaneous methadone provides postoperative analgesia that is non-inferior to that achieved with intrathecal morphine in women undergoing cesarean delivery under neuraxial anesthesia.
- Trial name
- SC-METH-CES (NCT07777029)
- Testing
- Methadone 0.15 mg/kg, morphine
- Volunteers
- 128 people
- Sponsor
- Clinica Alemana de Santiago
Opioid Use Disorder (OUD), Addictology
Autonomous Methadone Delivery System by Nurses
Initiations of methadone treatment for opiode use disorder (OUD) are carried out in France in specialized centers, known as centers for care, support and prevention in addictology (CSAPA) In this way, hospital practitioners…
- Trial name
- DIADEME (NCT07085377)
- Testing
- DIADEME strategy, Controle strategy, Individual semi directive interview
- Where
- 8 sites in France
- Volunteers
- 182 people
- Sponsor
- Hospices Civils de Lyon
Orthopedic Surgery
Intraoperative Methadone for the Prevention of Postoperative Pain
The pain felt after orthopedic surgery in the absence of adequate locoregional anesthesia is often insufficiently controlled, especially during the first 24 hours postoperatively.
- Trial name
- NCT05831345
- Testing
- Methadone Hydrochloride, Sufentanil Citrate
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Brugmann University Hospital
Pain, Postoperative
Methadone for Post-operative Spine Surgery
The goal of this prospective cohort study is to evaluate the clinical effects of post-induction methadone on perioperative pain control, opioid requirements, and recovery outcomes in adult patients undergoing elective spine…
- Trial name
- NCT07517679
- Testing
- Methadone, Standard of care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brandon Knopp
Opioid Use Disorder
Ketamine for Opioid Use Disorder
The goal of this clinical trial is to learn if ketamine works to reduce craving for opioids in adults enrolled in methadone treatment for opioid use disorder.
- Trial name
- NCT06943859
- Testing
- Treatment with Ketamine, Treatment with Very Low Dose Ketamine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Free Flap Reconstruction
Sufentanil Infusion vs Intravenous Methadone for Postoperative Analgesia Following Head and Neck Dissection With Free Flap or Rotational Reconstruction
The main purpose of this study is to determine which type of medication, sufentanil or methadone, is better at controlling pain during and, more importantly, after surgery in patients undergoing a head and neck dissection with…
- Trial name
- NCT06784999
- Testing
- sufentanil, methadone
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Indiana University
Food Security
Food Insecurity and Eating Behavior Among Adults Receiving Buprenorphine or Methadone Maintenance Treatment: Pilot Study 2
The goal of this study is to evaluate the effects of a novel, mail-based meal delivery intervention among individuals receiving MOUD on household food security status.
- Trial name
- NCT07251283
- Testing
- NE + Meal Delivery (NE+MD) intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Vermont
Patients Treated With Methadone
Methadone Administration in Critically Ill Patients in the Intensive Care Unit and Risk of Prolonged QTc and Cardiac Arrythmia
Continuous infusion of short-acting synthetic opioids, primarily remifentanil, is widely used for anesthesia and analgesia in ventilated patients in the intensive care unit (ICU) due to its short half-life, which is independent…
- Trial name
- NCT07892677
- Testing
- ICU patients treated with methadone
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Meir Medical Center
Chemotherapy-induced Peripheral Neuropathy
Methadone to Treat Painful Chemotherapy Induced Peripheral Neuropathy
Chemotherapy induced peripheral neuropathy (CIPN) or nerve pain, is a painful and debilitating complication which can chronically affect up to 70% of patients who receive chemotherapy.
- Trial name
- METACIN (NCT05786599)
- Testing
- methadone, duloxetine
- Where
- 4 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Arthroscopic Knee Repair, Arthroscopic Hip Repair
PO Methadone Ortho Outpatient
The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage.
- Trial name
- NCT06351215
- Testing
- Methadone group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Keck School of Medicine of USC
Opioid Use, Pain
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
This hybrid implementation-effectiveness trial will evaluate Mindfulness-Oriented Recovery Enhancement (MORE) for patients with opioid use disorder receiving methadone treatment (MT).
- Trial name
- IMPOWR-MORE (NCT06032559)
- Testing
- MORE, SMP, TAU
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- Rutgers, The State University of New Jersey