Clinical trials: Methadone
Drug-Drug Interaction
Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK
The main goal of this clinical study is to test how CYP2B6 genetic variations and efavirenz (cornerstone in HIV-1 therapy) dictate the disposition (PK) of CYP2B6 substrate (methadone) and PK and effect (PD) of CYP1A2 substrate…
- Trial name
- NCT05789173
- Testing
- Methadone and Tizanidine, Efavirenz, Methadone and Tizanidine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid-related Disorders, Opiate Dependence
Variation of COMT Val158Met Polymorphism Between COM-ON Patients and METHADOSE Patients
The main objective is to compare the genotypes of the COMT Val158Met polymorphism between opiate-users and opiate-dependent subjects.
- Conditions
- Opioid-related Disorders, Opiate Dependence, Opiate Addiction, Opiate Abuse
- Trial name
- COM-ON (NCT01570699)
- Testing
- COMT polymorphism
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
EKG-QT Prolongation
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery
A number of drugs used in the perioperative period may cause prolongation of the QT interval on the electrocardiogram (EKG). These drugs include inhalational agents, antiemetic agents, pain medications, and drugs used to reverse…
- Trial name
- NCT03893734
- Testing
- methadone, Hydromorphone
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Opioid Dependence, Pain
Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance
Pain is very common in persons with a history of addiction, but few studies have examined the best treatment of pain in this population.
- Conditions
- Opioid Dependence, Pain, Addiction
- Trial name
- NCT01642030
- Testing
- Hydromorphone, Buprenorphine
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins University
Post-herpetic Neuralgia
Methadone in Post-Herpetic Neuralgia Pain
Neuropathic pain is a common condition and affecting 40 to 70% of the general population. Post-herpetic neuralgia is a condition almost complex and requires a multi modal treatment.
- Trial name
- NPH (NCT01752699)
- Testing
- Methadone
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo
Candidiasis, HIV Infections
A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone
To evaluate the pharmacokinetics and safety of concomitant administration of methadone and fluconazole. Injection drug users constitute the second largest subset of the U.S.
- Trial name
- NCT00000788
- Testing
- Methadone hydrochloride, Fluconazole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Pain, Post-traumatic Stress Disorder
The Norwegian Addiction, Pain and Trauma Study
In populations with substance use disorders (SUD), there is a high prevalence of chronic pain with various underlying causes. Chronic pain can complicate the treatment of SUD and lead to poorer treatment outcomes.
- Conditions
- Chronic Pain, Post-traumatic Stress Disorder, Substance Use Disorders
- Trial name
- NOR-APT (NCT04908410)
- Where
- 4 sites in Norway
- Volunteers
- 1,650 people
- Sponsor
- University Hospital, Akershus
Opiate Addiction
Naltrexone Implants vs. MMT Among Inmates in the Norwegian Correctional Services
The purpose of this clinical trial is to study the efficacy and safety of naltrexone implants as a relapse prevention for opiate addicted inmates about to be released from prison.
- Trial name
- NCT00204243
- Testing
- Naltrexone, Methadone
- Where
- Norway
- Volunteers
- 46 people
- Sponsor
- University of Oslo