Clinical trials: Metformin
Methylglyoxal, PreDiabetes
Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals
The aim of this study is to compare the effects of exercise, standard lifestyle changes and metformin on MGO in prediabetic individuals.
- Conditions
- Methylglyoxal, PreDiabetes, Exercise, Metformin
- Trial name
- NCT06603480
- Testing
- Exercise, Metformin
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Type 2 Diabetes Mellitus
Phase III Trial to Evaluate the Efficacy and Safety of Initial Combination Therapy With Gemigliptin 50mg q.d and Metformin q.d
The objective of this study is to evaluate efficacy and safety of initial combination therapy with Gemigliptin 50mg q.d and Metformin q.d compared with either monotherapy in treatment naïve patients with type 2 diabetes, In other…
- Trial name
- NCT01787396
- Testing
- Gemigliptin 50mg, Metformin
- Where
- South Korea
- Volunteers
- 433 people
- Sponsor
- LG Life Sciences
Inflammatory Response
Effects of Metformin in a Non-Diabetic Patient Population
Metformin has a well-established safety profile and it has become clear that metformin has additional salutary effects, including anti-inflammatory, anti-aging, and anti-thrombotic properties.
- Trial name
- NCT03772964
- Testing
- MetFORMIN Hydrochloride ER
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brian Zuckerbraun
Schizophrenia, Obesity
Metformin for Weight Loss in Schizophrenia
Study hypothesis is that patients on antipsychotics medication treated with metformin will show loss in weight and improved measures of glucose metabolism.
- Trial name
- NCT01177709
- Testing
- Metformin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Diabetes Mellitus, Type 2
Effect of Metformin on Gut Peptides , Bile Acids and Lipid Profiles in Type 2 Diabetics
Metformin is a biguanide that is marketed as an oral anti-diabetic drug. Metformin treatment in concert with diet and exercise is the consensus first-line treatment for type 2 diabetes mellitus (T2DM), and therefore it will…
- Trial name
- NCT01357876
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Healthy
Metformin and Furosemide Drug-Drug Interaction Study
This study will assess the potential effects of lesinurad on the pharmacokinetics (PK) of metformin and furosemide in healthy, adult male subjects.
- Trial name
- NCT02028689
- Testing
- Lesinurad 400 mg, Metformin 850 mg, Furosemide 40 mg
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ardea Biosciences, Inc.
Type 2 Diabetes Mellitus
A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Insulin With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-254)
A study to compare safety and efficacy of sitagliptin and placebo therapy when added to stable insulin alone or in combination with metformin in participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01590797
- Testing
- Sitagliptin, Insulin, Metformin
- Volunteers
- 467 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity
Glaser Obesity Study
This study will determine if the drug metformin, coupled with diet and exercise counseling, will help obese adolescents lose weight.
- Trial name
- NCT00209482
- Testing
- glucophage XR
- Where
- 5 sites in United States
- Volunteers
- 76 people
- Sponsor
- Glaser Pediatric Research Network
Diabetes, Diabetes Mellitus, Type 2
Investigating Efficacy and Safety of Biphasic Insulin Aspart 50 Twice Daily Versus Biphasic Human Insulin 50 Twice Daily Both in Combination With Metformin in Chinese Subjects With Type 2 Diabetes Mellitus
This trial is conducted in Asia. The aim of the trial is to investigate the efficacy and safety of biphasic insulin aspart 50 (BIAsp 50) twice daily versus biphasic human insulin 50 (BHI 50) twice daily, both in combination with…
- Trial name
- NCT01892020
- Testing
- biphasic insulin aspart 50, biphasic human insulin 50
- Where
- China
- Volunteers
- 161 people
- Sponsor
- Novo Nordisk A/S
Breast Cancer Female
IGF Level in Breast Cancer Patients Treated With Metformin
The purpose of this study is to examine the impact of metformin as an adjuvant to chemotherapy on IGF levels in both progressing and non progressing cases of metastatic breast cancer in female patients.
- Trial name
- NCT05840068
- Testing
- MetFORMIN 500 Mg Oral Tablet, Chemotherapy
- Where
- Egypt
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Prediabetes, Impaired Fasting Glucose
Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes
Pre diabetes (PD) is a term that refers to alterations in glucose homeostasis, including impaired fasting glucose (IFG), Imparied glucose tolerance (IGT) or both, involving a higher risk to develop type 2 diabetes mellitus (T2DM)…
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT03029390
- Testing
- Berberine, Metformin
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- University of Guadalajara
Melanoma
A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients
The main purpose of this study is to evaluate the safety of Vemurafenib in combination with Metformin in melanoma patients. The phase II part of the study will also evaluate the clinical activity of the combined regiment.
- Trial name
- NCT01638676
- Testing
- Vemurafenib, Metformin
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Louisville
Type 2 Diabetes Mellitus
A Study to Assess the Efficacy and Safety of Ipragliflozin in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin
The main purpose of this study is to evaluate the efficacy in reducing glycated hemoglobin of ipragliflozin in combination with metformin compared with metformin plus placebo in subjects with type 2 diabetes mellitus who have…
- Trial name
- IMPRESSION (NCT02794792)
- Testing
- Ipragliflozin L-proline, Metformin
- Where
- 14 sites in Russia
- Volunteers
- 268 people
- Sponsor
- Astellas Pharma Europe B.V.
Dissecting Aneurysm of Cerebral Artery
Metformin in Patients With Unruptured Vertebrobasilar Dissecting Aneurysms (METTLE)
Vertebrobasilar dissecting aneurysms (VBDAs) are one of the most important causes of stroke in young and middle-aged people, and the natural history of VBDAs is complex and varied, often leading to high rates of disability and…
- Trial name
- METTLE (NCT06405971)
- Testing
- Metformin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ming Lv
Metabolic Syndrome
Metformin in Postmenopausal Women With Metabolic Syndrome
The purpose of this study is to determine the effects of metformin on cardiovascular risk factors in postmenopausal women with metabolic syndrome.
- Trial name
- NCT01342744
- Testing
- Metformin
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Nonalcoholic Fatty Liver Disease
Effect of Treatment With Insulin Sensitizer on Arterial Properties, Metabolic Parameters and Liver Function in Patients With Nonalcoholic Fatty Liver Disease
Abstract Background: Insulin resistance has an important role in the development of nonalcoholic fatty liver disease (NAFLD) and is involved in both pathological processes: hepatic steatosis and atherosclerosis.
- Trial name
- NCT01084486
- Testing
- Metformin
- Where
- Israel
- Sponsor
- Wolfson Medical Center
Gestational Diabetes Mellitus in Pregnancy
Comparison Between Metformin and Glyburide in the Management of Gestational Diabetes
This study aims to compare the maternal, fetal, and neonatal outcomes associated with the use of metformin versus glyburide for managing gestational diabetes.
- Trial name
- NCT06589141
- Testing
- MetFORMIN 500 Mg Oral Tablet, GlyBURIDE 2.5 MG Oral Tablet
- Volunteers
- 180 people
- Sponsor
- Assiut University
Diabetes Mellitus
AMG 151 Amgen Protocol Number 20100761
This is a phase 2a, multicenter, randomized, double-blind, placebo-controlled, parallel group, fixed dose study. AMG 151 will be evaluated in subjects with type 2 diabetes treated with metformin for at least 3 months prior to…
- Trial name
- NCT01464437
- Testing
- AMG 151, Metformin
- Where
- 77 sites in United States, Czechia and 3 more
- Volunteers
- 236 people
- Sponsor
- Amgen
Healthy
DDI (Effect of Metformin and Furosemide on Rosuvastatin PK)
The primary objective of this trial is to investigate the relative bioavailability of rosuvastatin when given alone (Reference treatment, R) compared to when given together with one of the three different doses of metformin (10…
- Trial name
- NCT02574845
- Testing
- Rosuvastatin, Metformin HCl, Furosemide
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Epithelial Ovarian Cancer
Study of Metformin With Carboplatin/Paclitaxel Chemotherapy in Patients With Advanced Ovarian Cancer
Molecularly targeted agents which inhibit the mammalian target of rapamycin (mTOR) pathway and/or circumvent p53 in the induction of apoptosis are exciting potential targets in ovarian cancer.
- Trial name
- OVMET (NCT02312661)
- Testing
- Metformin, Carboplatin, Paclitaxel
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen