Clinical trials: Metastatic Liver Cancer
Metastatic Colorectal Cancer
Evaluation of Contrast-enhanced Ultrasound Imaging for the Early Estimate of Bevacizumab Effect on Colorectal Cancer Liver Metastases
Bevacizumab, an anti-angiogenic agent, plus fluorouracil based chemotherapy is considered a new standard for the treatment of metastatic colorectal cancer.
- Trial name
- NCT00489697
- Testing
- real-time contrast-enhanced ultrasound imaging (CEUS)
- Where
- 12 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Liver Metastases of Colorectal Cancer
Chemotherapy Plus EGFR Monoclonal Antibody in Patients With Liver Metastases From Colorectal Cancer With ctDNA Superselective Negative Genes
The purpose of this Phase II single-arm study is to prospectively explore the efficacy of chemotherapy plus EGFR inhibitors in patients with liver metastases from total wild-type colorectal cancer with ctDNA superselective…
- Trial name
- NCT06490913
- Testing
- Capecitabine, oxaliplatin, Cetuximab
- Volunteers
- 33 people
- Sponsor
- Fujian Cancer Hospital
Metastatic Hepatocellular Carcinoma
A Study Evaluating Atezolizumab and Bevacizumab Plus ADI-PEG 20 in Patients With Locally Advanced / Metastatic Hepatocellular Carcinoma
To learn about the safety and tolerability of atezolizumab, bevacizumab, and ADI-PEG 20 when given in combination to patients with locally advanced or metastatic liver cancer
- Trial name
- NCT06006286
- Testing
- Atezolizumab, Bevacizumab, ADI-PEG 20
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Liver Cancer, Liver Metastasis Colon Cancer
Microwave Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms
The goal of this observational study is to collect data on efficacy and safety of microwave ablation (MWA) used to treat subjects with primary and secondary liver malignancies and renal malignancies.
- Conditions
- Liver Cancer, Liver Metastasis Colon Cancer, Kidney Cancer, Renal Cell Carcinoma
- Trial name
- NCT03981497
- Testing
- Microwave ablation (MWA)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Francesco De Cobelli
Nausea, Vomiting
Acupoint Electric Stimulation Combined With Tropisetron in Preventing and Treating Nausea and Vomiting After TACE
Observation on acupoint electric stimulation combined with tropisetron in preventing and treating nausea and vomiting and improving the patient's appetite after TACE for primary or metastatic liver cancer patients.
- Conditions
- Nausea, Vomiting, Metastatic Liver Cancer
- Trial name
- NCT01895010
- Testing
- acupoint electric stimulation, tropisetron
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Fudan University
Carcinoma, Hepatocellular, Neoplasm Metastasis
Therasphere® for Treatment of Unresectable Primary Liver Cancer and Metastatic Liver Cancer
The purpose of this protocol is to provide supervised and limited access to Therasphere® treatment for patients with primary liver cancer and chemotherapy refractory liver metastasis who cannot be treated by surgical removal of…
- Trial name
- NCT00701168
- Testing
- yttrium Y 90 microspheres (Therasphere®)
- Where
- United States
- Sponsor
- Leo W. Jenkins Cancer Center
Radiotherapy, Immunotherapy
Postoperative Chemotherapy With/Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With High Risk of Locally Recurrence
This study is a randomized controlled phase II trial to evaluate the efficacy of the combination of stereotactic body radiation therapy (SBRT) and immunotherapy with postoperative chemotherapy in colorectal cancer liver…
- Conditions
- Radiotherapy, Immunotherapy, Liver Metastases, Colorectal Cancer
- Trial name
- IMPROVE (NCT06120127)
- Testing
- SBRT, Chemotherapy, PD-1 antibody
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Hepatocellular Carcinoma (HCC)
A Phase I Study of ERY974 in Patients With Hepatocellular Carcinoma
This is a multicenter, open-label, dose-escalation study designed to determine the maximum tolerated dose (MTD) by evaluating dose-limiting toxicities (DLTs) and to evaluate the safety, tolerability, pharmacokinetics, anti-tumor…
- Trial name
- NCT05022927
- Testing
- ERY974, Tocilicumab, Atezolizumab
- Where
- 11 sites in Japan, Taiwan
- Volunteers
- 179 people
- Sponsor
- Chugai Pharmaceutical
Genomic Instability, Prognostic Cancer Model
Genomic Signatures for Patients With Initially Unresectable Colorectal Liver Metastases
A retrospective cohort of 286 patients with synchronous CRLM underwent conversion therapies based on next-generation sequencing (NGS) results.
- Trial name
- NCT06477718
- Volunteers
- 286 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Liver Cancer
Arsenic Trioxide in Treating Patients With Metastatic Liver Cancer That Cannot Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as arsenic trioxide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00128596
- Testing
- arsenic trioxide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Thyroid Pathology, Head and Neck Cancer (H&N)
FAPI PET Imaging - An Exploratory Study
This study is testing a new imaging tracer called [18F]FAPI-74 with PET scans. Researchers want to find out how well this tracer shows certain diseases in the body, including several types of cancer and some non-cancer conditions…
- Conditions
- Thyroid Pathology, Head and Neck Cancer (H&N), Sinonasal Tract Tumor, Sarcoidosis
- Trial name
- FAPIPET (NCT07705074)
- Testing
- [18F]FAPI-74 PET/CT
- Where
- 5 sites in Switzerland
- Volunteers
- 770 people
- Sponsor
- Martin Huellner
Colorectal Carcinoma, Liver Metastases
Anatomical Resection VS. Nonanatomical Resection for Colorectal Liver Metastases With Gene Mutation or Right-sidedness
In this study, colorectal cancer patients with initially resectable liver-only metastases, as prospectively confirmed by a local multidisciplinary team (MDT) according to predefined criteria, will be tested for RAS and BRAF tumor…
- Trial name
- NCT05881746
- Testing
- anatomical liver resection, nonanatomical liver resection
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Fudan University
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hepatocellular Carcinoma, Metastasis
Radiofrequency Ablation Using Octopus Electrodes for Treatment of Focal Liver Malignancies
The purpose of this study is to evaluate the clinical feasibility and short-term outcome of switching monopolar RFA using a separable cluster electrode in patients with primary and secondary liver malignancies.
- Conditions
- Hepatocellular Carcinoma, Metastasis, Cholangiocarcinoma
- Trial name
- NCT02683538
- Testing
- Separable cluster electrode (Octopus®)
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer With Liver Metastasis
Prospective Phase II Trial on Prophylactic Perihepatic Lymphadenectomy in Patients With Colorectal Cancer With Liver Metastasis
Objective: To evaluate the role of regional lymphadenectomy in patients with colorectal cancer liver metastasis. Background: Lymph node status is 1 of the most important prognostic factors in oncologic surgery; however, the role…
- Trial name
- LN (NCT01565811)
- Testing
- perihepatic lymphadenectomy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Gachon University Gil Medical Center
Metastatic Melanoma, Pulmonary Metastases
Radiation Therapy With Combination Immunotherapy for Relapsed/Refractory Metastatic Melanoma
This is a Phase 1b/2 study designed to evaluate combination of the human T-cell cytokine Interleukin-2 (IL-2) and a checkpoint inhibitor Ipilimumab immediately following a course of hypofractionated palliative radiation therapy…
- Conditions
- Metastatic Melanoma, Pulmonary Metastases, Hepatic Metastases, Brain Metastases
- Trial name
- NCT03297463
- Testing
- Interleukin-2 & Ipilimumab (P-Ib), Interleukin-2 & Ipilimumab (P-II)
- Where
- United States
- Sponsor
- Masonic Cancer Center, University of Minnesota
Neuroendocrine Tumors, Liver-Dominant Metastatic Pancreatic Neuroendocrine Tumors
Lutathera in People With Gastroenteropancreatic (GEP), Bronchial or Unknown Primary Neuroendocrine Tumors That Have Spread to the Liver
This study will look at whether it is practical and safe to give Lutathera directly into an artery of the liver (hepatic intraarterial infusion).
- Trial name
- NCT04544098
- Testing
- 177Lu-DOTATATE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer Metastatic
AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer
This is a single center, open label dose frequency escalation study of CryoVax®. personalized anti-tumor vaccine protocol combining the cryoablation of a selected metastatic lesion with intra-lesional immunotherapy with…
- Trial name
- NCT02380443
- Testing
- AlloStim, Cryoablation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mirror Biologics, Inc.
Colorectal Cancer With Liver Metastases
ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer ( MetaIRM)
Currently, the tumor response of operated colorectal liver metastases is assessed by histology of the resection specimen.The histological data make it possible to define categories (responder, partial responder, non-responder).
- Trial name
- MetaIRM (NCT06552117)
- Testing
- an elastoMRI sequence
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Diseases, Liver Transplantation
Hepatic and Systemic Hemodynamic Modeling During Liver Surgery
" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific…
- Trial name
- LSM (NCT05339984)
- Testing
- Partial hepatectomy (open approach), liver transplantation, Portal vein embolization
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris