Clinical trials: Metagenomic Next Generation Sequencing
Infections, Critical Illness
Detection of Pathogen and Antibiotic Resistance Genes by Targeted Next-Generation Sequencing in ICU Patients.
It is difficult to determine the pathogens in the early stage of infection in critically ill patients, and empirical use of broad-spectrum antibiotics for a long time is often necessary, leading to antibiotics drug resistance.
- Conditions
- Infections, Critical Illness, Diagnosis
- Trial name
- NCT06157372
- Testing
- targeted next-generation sequencing (tNGS)
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Parapneumonic Effusion
Metagenomic Study in Parapneumonic Effusion
Objective: To identify known and unknown bacterial pathogens in patients with pleural infections using a combination of conventional culture and next-generation sequencing approaches.
- Trial name
- NCT05394220
- Testing
- 16S rRNA gene amplicon sequencing
- Where
- Hong Kong
- Volunteers
- 115 people
- Sponsor
- Chinese University of Hong Kong
Invasive Pulmonary Fungal Disease
Blood mNGS for Diagnosing Invasive Pulmonary Fungal Disease in Hematologic Patients
The goal of this clinical trial is to learn whether a blood test called metagenomic next-generation sequencing (mNGS) can help diagnose invasive pulmonary fungal disease in patients with blood disorders.
- Trial name
- NCT07511595
- Testing
- Blood microbial metagenomic next-generation sequencing (mNGS)
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Severe Acute Respiratory Infection, Community-acquired Pneumonia
mNGS -Guided Antimicrobial Treatment in Early Severe Community-Acquired Pneumonia Among Immunocompromised Patients
Severe Community-acquired pneumonia (SCAP) is a leading global infectious cause of intensive care unit (ICU) admission (approximately 20%-30%), and the primary reason of mortality and morbidity in immunocompromised patients.
- Conditions
- Severe Acute Respiratory Infection, Community-acquired Pneumonia, Respiratory Tract Infections, Pneumonia
- Trial name
- MATESHIP (NCT05290454)
- Testing
- mNGS-guided treatment
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Qilu Hospital of Shandong University
Cirrhosis, Liver
Microbiome Translocation in Different Circulatory Compartments in Decompensated Cirrhosis
Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections contributing to disease progression and may lead to the development of acute-on-chronic liver failure (ACLF).
- Trial name
- NCT04195724
- Testing
- mNGS for pathogen detection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Myeloid Leukemia, Adult
Investigation of the Gut Microbiota in Acute Myeloid Leukemia Receiving Two Different Induction Therapies
In this observational single-center cohort study, metagenomic Next-Generation Sequencing (mNGS) will be used to investigate the features and changes of gut microbiota in acute myeloid leukemia (AML) patients during the treatment…
- Conditions
- Acute Myeloid Leukemia, Adult, Gut Microbiota, Infections
- Trial name
- NCT05123352
- Testing
- collection of biological samples and clinical data
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Cirrhosis, Liver
Pathogenic Metagenomic Next-generation Sequencing to Optimize the Diagnosis of Decompensated Cirrhosis Infection
The goal of this observational study is to learn about clinical application of pathogenic metagenomic next-generation sequencing to optimize the diagnosis of infection in decompensated cirrhotic patients.
- Trial name
- NCT06039696
- Where
- China
- Volunteers
- 850 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Preterm Rupture of Membranes
Identification of Microbial DNA in Maternal Plasma After PPROM
This study evaluates the use of metagenomic next generation sequencing in identifying microbial DNA in plasma samples of patients with preterm premature rupture of membranes.
- Trial name
- NCT04318470
- Testing
- mNGS
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ascites Infection
Metagenomic Next-Generation Sequencing for Diagnosis of Ascites Infection in End-stage Liver Diseases
Ascites is the most common complication of cirrhosis, and its development is associated with substantially increased mortality. Ascites infection including spontaneous bacterial peritonitis (SBP), bacterascites and fungal…
- Trial name
- NCT04125654
- Testing
- mNGS for pathogen detection
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Central Nervous System (CNS) Infection, Encephalitis
Establishment of Prevention and Control System of Central Nervous System Infection
Central nervous system (CNS) infection is a common nervous system acute and severe disease, mainly manifested as encephalitis, meningitis and meningoencephalitis, but also manifested as brain abscess and brain granuloma et al.
- Conditions
- Central Nervous System (CNS) Infection, Encephalitis, Meningitis
- Trial name
- NCT04722328
- Testing
- CSF metagenomic next generation sequencing (mNGS)
- Where
- China
- Volunteers
- 715 people
- Sponsor
- Xuanwu Hospital, Beijing
Pneumonia, Metagenomic Next Generation Sequencing
Second-generation Sequencing Guides the Treatment of Severe Pneumonia
Investigators plan to conduct the participants level, 1:1 randomized trial at the Central ICU and respiratory ICU of Xiangya Hospital in Changsha, China, from January 1, 2018 to December 31, 2019.
- Trial name
- NGS (NCT03884881)
- Testing
- metagenomic next generation sequencing, Conventional pathogen detection, Meropenem，Imipenem，Caspofene，Osstat
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xiangya Hospital of Central South University
Bacterial Infections
Evaluation of a mNGS Workflow for Infection Diagnosis Using Oxford Nanopore Sequencing.
This is a laboratory evaluation of a new testing methodology for microbiological diagnosis, whereby participant samples received as part of routine care will be divided between the standard diagnostic pathway and this new…
- Trial name
- NCT04864873
- Testing
- Metagenomic next generation sequencing using Oxford Nanopore, Standard microbiological diagnostic pathway
- Where
- New Zealand
- Volunteers
- 400 people
- Sponsor
- Capital and Coast District Health board
Respiratory Pathogens
Prospective Study of Multi-centers Exploring the Difference of Clinical Impact by Using Respiratory Pathogen ID/AMR Panel (RPIP) Versus Untarget Metagenomic Next-generation Sequencing (mNGS) and Multiplex PCR in Pathogen Identification of Pneumonia Patients in Intensive Care Unit
Pneumonia, pathogen involved to lower respiratory tract and leading lung parenchyma infection, is one of the three most common infectious diseases in the world.
- Trial name
- NCT07626073
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- China Medical University Hospital
Central Nervous System Infection
Investigation of the Delve Detect Cerebrospinal Fluid (CSF) Metagenomic Next-generation Sequencing (mNGS) Test When Used for the Initial Diagnostic Workup of Patients With Suspected Central Nervous System (CNS) Infection
Delve Bio, Inc. is a developer of novel mNGS tests with the goal of aiding in the diagnosis of infectious diseases in several clinical indications that may not have alternative traditional diagnostic methods routinely available.
- Trial name
- IMPACT (NCT07435649)
- Testing
- Delve Detect CSF mNGS Test, Real-World Data
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Delve Bio, Inc.
HIV Infection
Pathogen Detection in HIV-infected Children With Non-malarial Febrile Illnesses Using Metagenomic Sequencing
In Uganda, 130,000 children (0-14 years of age) were living with HIV in 2018. Last year, nearly 450 infants acquired HIV every day; most of them during childbirth and these are at extremely high risk of dying in the first two…
- Trial name
- PHICAMS (NCT05085158)
- Where
- Uganda
- Volunteers
- 138 people
- Sponsor
- Makerere University
Vascular Graft Infection, Infectious Aortitis
China Aortic Infection and Graft Infection Study: An Ambispective Cohort
Vascular infections are uncommon but severe infections involving the arterial wall, vascular grafts, or endografts, and their diagnosis and management remain challenging.
- Conditions
- Vascular Graft Infection, Infectious Aortitis, Aortoenteric Fistula
- Trial name
- CAIGIS (NCT07847346)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Gonorrhea, Neisseria Gonorrhea
Metagenomic Analysis of the Pharynx in High Risk Partners
The Neisseria gonorrhoea (NG) epidemic in England is at the highest level in one hundred years of public health records. The World Health Organisation has listed NG as one of the top five bacterial infections globally because of…
- Conditions
- Gonorrhea, Neisseria Gonorrhea, Neisseria Meningitidis, Metagenomic Next Generation Sequencing
- Trial name
- NCT07671014
- Volunteers
- 100 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Spinal Infection, Diagnositic Efficacy
Diagnostic Efficacy of Metagenomic Next-generation Sequencing in Patients With Spinal Infections: A Retrospective Study
Comparing the diagnostic efficacy between traditional laboratory methods and second-generation high-throughput sequencing in patients suspected of spinal infections.
- Trial name
- NCT06172153
- Testing
- No interventions
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University