Clinical trials: Metabolomics
Colorectal Cancer
Point of Care Test to Diagnosed Colorectal Cancer and Polyps in Low Middle Income Countries
This is a-two phase study. Phase 1 will adapt a 3-metabolite biosensor that identifies patients with colorectal cancer (CRC) and precancerous polyps to Nigerian patients.
- Trial name
- NCT03173729
- Testing
- Biosensor Point of Care Device
- Where
- 5 sites in Nigeria
- Volunteers
- 926 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Renal Transplantation
Metabolomics in Assessing the Quality of Kidney Transplants Retained on a LifePort® Perfusion Machine
When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft.
- Trial name
- RENALIFE (NCT03024229)
- Testing
- LifePort® perfusion machine
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Hypobaric Hypoxia, Metabolomics
Oxidative Stress in Hypobaric Hypoxia
The trial investigates changes in metabolism during high altitude expedition up to 6865m. A mass-spectrometry based platform is used to detect different oxidative stress related metabolites.
- Conditions
- Hypobaric Hypoxia, Metabolomics, Oxidative Stress, Acute Mountain Sickness
- Trial name
- NCT01436383
- Testing
- Hypoxic exposure
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Endometriosis
Endometriosis Impact on Oocyte Quality
The aim of this study is to evaluate the impact of endometriosis on folliculogenesis and oocyte quality. To do so, a metabolomic approach will be conducted in order to analyze the follicular fluid.
- Trial name
- EndOvo (NCT03241329)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myelinopathy
Association of Plasma Metabolomic Biomarkers with Chronic Ischemic White Matter Injury
The cases were screened according to the inclusion criteria, and after the patients signed the informed consent, the clinical data were collected, the imaging data were evaluated, and blood samples were taken for follow-up…
- Trial name
- WML (NCT06608251)
- Testing
- white matter lesion
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Colorectal Cancer
Developing Objective Fatigue Indicators in Colorectal Cancer Survivors.
The aims of this four-year study are to 1. Explore exercise behavior, exercise barriers, and identify the significant factors for exercise behavior in colorectal cancer survivors. 2.
- Trial name
- NCT01700283
- Testing
- exercise education and walking program
- Where
- Taiwan
- Volunteers
- 306 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis
Investigation on the Role of Gut-liver Axis for Non-alcoholic Steatohepatitis Through Bariatric Surgery
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Non-alcoholic steatohepatitis (NASH) is an aggressive form of NAFLD with remarkable inflammatory features which may cause advanced fibrosis and…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, Bariatric Surgery
- Trial name
- NCT04501042
- Testing
- Bariatric surgery
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Polycystic Ovary Syndrome
Serum Metabolomics Study of Traditional Chinese Medicine Formula （Shen Qi Tiao Ti Formula） Intervention to Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a most common, heterogeneous, complex endocrinopathy disease.Traditional Chinese medicine (TCM) has been used in the treatment of PCOS for many years.
- Trial name
- NCT03623451
- Testing
- Chinese Medicine Formula
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Major Depressive Disorder
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
This is a study that will test a predictive biomarker algorithm based on results from a previous study. The goal of this study is to integrate clinical, imaging, EEG, and molecular data across 8 sites to predict treatment outcome…
- Trial name
- CAN-BIND-17 (NCT05017311)
- Testing
- Escitalopram, Brexpiprazole
- Where
- 10 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Non-alcoholic Fatty Liver Disease (NAFLD), NASH - Nonalcoholic Steatohepatitis
Integrated Phenotyping of the Gut-plAtelet-Liver AXIS in the Progression of Chronic Liver Disease (iGAL-AXIS)
Objective of the study Our working hypothesis is that platelets activated by gut-derived metabolites dock in the liver of NAFLD patients and amplify the inflammatory state by releasing pro-inflammatory cytokines/chemokines, which…
- Conditions
- Non-alcoholic Fatty Liver Disease (NAFLD), NASH - Nonalcoholic Steatohepatitis, Cirrhosis, Control Condition
- Trial name
- NCT06623084
- Testing
- Platelets characterization
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Stefania Basili
Obesity
Acupuncture for Obesity on Serum Metabolic Parameters
This research is planned to build a basis about the effect of acupuncture on serum metabolic parameters in pre-menopausal obese women with economic evaluation.
- Trial name
- NCT02066090
- Testing
- Real acupuncture
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Idiopathic Pulmonary Fibrosis
Traditional Chinese Medicine(TCM) Syndrome Classification of Idiopathic Pulmonary Fibrosis(IPF) and Metabolomics
The pathogenesis of idiopathic pulmonary interstitial fibrosis is complex, and there is no specific biomarkers, the treatment effect is not such useful.
- Trial name
- NCT03711435
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Xuzhou Traditional Chinese Medicine Hospital
Alcoholic Hepatitis (AH)
Recompensation in Alcohol Related Hepatitis
Genetic activity and metabolic changes may be part of the pathogenesis in alcohol related hepatitis. We do not know exactly how alcohol cessation affects liver functions and metabolism.
- Trial name
- A-HEP (NCT06740318)
- Testing
- Motivational enhancement therapy
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Nina Kimer
Postoperative Delirium (POD), Postoperative Bleeding
GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.
The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery…
- Conditions
- Postoperative Delirium (POD), Postoperative Bleeding, Acute Kidney Injury, Atrial Fibrillation (AF)
- Trial name
- GENECARD (NCT07345403)
- Testing
- Multi-Omics Data and Clinical Data Collection
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Medical University of Gdansk
Pancreatic Fistula, Acute Pancreatitis
METabolomic and Immune PROfiling in the Development of Pancreatic Fistulas After cepHalic duodEnopancreatectomy
Pancreatoduodenectomy is the standard surgical operation for benign or malign pancreatic lesions. Pancreatic Fistula (PF) or Postpancreatectomy Acute Pancreatitis (PPAP) are the major complications associated with that type of…
- Conditions
- Pancreatic Fistula, Acute Pancreatitis, Pancreatoduodenectomy
- Trial name
- PROMETHEE (NCT06283160)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon