Clinical trials: Metabolome
Obesity
Influence of Probiotic and Symbiotic in Body Weight, Blood Sugar and Lipemia of Obese Women
The purpose of this study is to evaluate whether gut microbiota modulation by probiotic and symbiotic contribute with weight loss and improvement of metabolic parameters in women with obesity.
- Trial name
- NCT02505854
- Testing
- Probiotic, Symbiotic
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Metabolic Syndrome, Inflammation
Impacts of Aronia on Inflammation and the Gut Microbiome
The overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia berries. Inflammation is an underlying mechanism driving the development of several diseases.
- Conditions
- Metabolic Syndrome, Inflammation, Hypertriglyceridemia, Obesity
- Trial name
- NCT04128839
- Testing
- Aronia berry juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montana State University
Microbiota, Gastrointestinal Microbiome
Assessing the Dose Response of a Lead Fiber Snack Prototype
Aim: To test the effects of a fiber-blend containing snack prototype in an escalating dose regimen (from 1 to 3 servings per day over a period of 6 weeks) on the configuration and gene content of the gut microbiota of overweight…
- Trial name
- FDR (NCT04729816)
- Testing
- Controlled, high fat/low fiber diet background diet, sequentially supplemented with an escalating dose of a fiber-blend snack food.
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cervical Adenocarcinoma, Human Papillomavirus
HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections.
- Conditions
- Cervical Adenocarcinoma, Human Papillomavirus, Genome-wide Association Study, Whole Exome Sequencing
- Trial name
- NCT03742869
- Testing
- A multi-omics analysis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Lei Li
Rectal Cancer
Mesorectal Microbiome and Metabolome as a Prognostic Factor in Patients With Rectal Cancer
The equilibrium of intestinal microorganisms is essential for health an imbalance has been associated with an increased risk in the development of different pathologies; including colorectal cancer.
- Trial name
- BIORECTUM (NCT04804956)
- Testing
- Stool sample, Rectal mucosa sample, Mesorectal adipose tissue sample
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- University Hospital of Girona Dr. Josep Trueta
Healthy
Polyunsaturated Fatty Acids Supplementation and Blood Metabolome
Analysis of the effect of dietary intervention based on increased polyunsaturated fatty acid intake on health. Specifically changes in blood lipid profile, as well as proteomic and metabolomic profiles of healthy adults will be…
- Trial name
- NCT03892486
- Testing
- The high PUFA diet group
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Endocrine Disease
New Clinical Decision Support Score Based on Steroid Hormone Profiling in the Diagnosis of MACS
The recent development of quantitative steroid metabolome profiling could be of interest for the positive diagnosis of mild autonomous cortisol-secreting adenoma (MACS).
- Trial name
- MACSCORE (NCT07352527)
- Where
- France
- Volunteers
- 291 people
- Sponsor
- University Hospital, Bordeaux
Heart Diseases, Microbial Colonization
Dairy Fat and Fermentation Study
The purpose of the study is to compare the effect of consuming full-fat (regular) and fat-free (skim) milk, as well as full-fat and fat-free yogurt (a fermented dairy product), on microorganisms in your gut as well as the…
- Conditions
- Heart Diseases, Microbial Colonization, Inflammation
- Trial name
- NCT05840081
- Testing
- Milk or yogurt beverage
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tufts University
Phenylketonuria
Impact Of A Phe-Restricted Diet On Gut Health In Children With PKU
Phenylketonuria (PKU) is an inherited disorder of phenylalanine (Phe) metabolism. The mainstay of treatment is a Phe-restricted diet, which aims to maintain blood Phe concentrations within the recommended range and prevent…
- Trial name
- NCT07728032
- Testing
- Phenylalanine-restricted diet alone, Sapropterin Dihydrochloride, Sepiapterin
- Where
- United Kingdom
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Healthy
Pre-analytical Sample Handling Conditions and Their Effects on the Human Urine Metabolome
This study evaluates how urine handling conditions can affect the concentrations of ~1,000 urine metabolites and attempts to quantify the degree of attenuation and/or potential bias in epidemiologic associations that may result…
- Trial name
- NCT03063502
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
Acute Coronary Syndrome
Impact of MEditerranean Diet, Inflammation and Microbiome After an Acute Coronary Syndrome
In the MEDIMACS project, the investigators will use a randomized clinical-trial design to address the effects of mediterranean diet on atherosclerotic plaque vulnerability and coronary endothelial function in order to decipher…
- Trial name
- MEDIMACS (NCT03842319)
- Testing
- Microbiota analysis, Immunological analysis, Proteome analysis
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Coronary Heart Disease
Multi-omics Study of Clinical Endpoints in CHD
This study aimed to explore underlying mechanisms of individual differences in drugs for coronary heart disease treatment and its association with adverse consequences.
- Trial name
- OmiDETCHD (NCT03797339)
- Testing
- risk factors of adverse cardiovascular events, multi-omics target discovery, validation
- Where
- 5 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Metabolic Syndrome
FRUVEDomics: Behavioral Intervention in Young Adults to Identify Metabolomics and Microbiome Risk
Rates of obesity and the metabolic syndrome are increasing in the young adult population (years 18-28). Modifying diet, especially increasing fruit and vegetable intake, can help assist in health maintenance and disease…
- Trial name
- FRUVEDomics (NCT03115866)
- Testing
- FRUVEDomics
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Normal Cellular Metabolism
In Vivo Assessment of Cellular Metabolism in Humans
This is a pilot study to establish an arterial venous methodology to measure the activity of the TCA cycle or flux directly in tissues of human beings.
- Trial name
- NCT02748369
- Testing
- Somatostatin, Glucagon
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- K. Sreekumaran Nair
Mechanisms, Defense
The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota
The overall purpose of this study is to evaluate the effect of nutritional supplementation with a well-characterized preparation of Concord grape polyphenol-soy protein isolate (GP-SPI) on the composition of the gut microbiota.
- Trial name
- NCT04018066
- Testing
- GP-SPI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Polycystic Ovary Syndrome
DAISy-PCOS Phenome Study - Dissecting Androgen Excess and Metabolic Dysfunction in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 10% of all women and usually presents with irregular menstrual periods and difficulties conceiving.
- Trial name
- DAISy-PCOS (NCT03911297)
- Testing
- Women with polycystic ovary syndrome
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Autism Spectrum Disorder
Effects of Probiotic Consumption in Children With Autism Spectrum Disorder (ASD)
The goal of this clinical trial is to determine the effects of Saccharomyces boulardii (Sb) consumption on Ecuadorian children with a diagnosis of autism spectrum disorder (ASD) and digestive symptoms.
- Trial name
- NCT06568588
- Testing
- S. boulardii CNCM (National Collection of Cultures of Microorganisms) I-745
- Where
- Ecuador
- Volunteers
- 66 people
- Sponsor
- Universidad San Francisco de Quito
CKD, PAD - Peripheral Arterial Disease
Oral Absorbent and Probiotics in CKD Patients With PAD on Gut Microbiota, IncRNA, Metabolome, and Vascular Function
Taiwan has more chronic kidney disease (CKD) per capita than anywhere in the world, leading to the highest expense of National Health Insurance.
- Trial name
- NCT04792320
- Testing
- Active bamboo charcoal, probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Inflammatory Bowel Disease (IBD)
Omics-driven Research on the Gut-Oral Microbiome, Metabolome, Lifestyle, and Clinical Integration in Korean Inflammatory Bowel Disease
The inflammatory bowel disease (IBD) is a condition that afflects approximately 5 million people worldwide, with 1.4 million in the US and 2.2 million in Europe.
- Trial name
- ORIGIN (NCT06124833)
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Chang Kyun Lee