Clinical trials: Metabolic Response
Insulin Resistance
Surgical Stress After Laparoscopic Compared to Open Liver Resection
The purpose of this study is to determine whether the postoperative insulin resistance and cytokine release would be attenuated in laparoscopic compared with open liver resection.
- Trial name
- NCT01819688
- Testing
- laparoscopic liver resection
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sir Run Run Shaw Hospital
Inflammation, Magnesium Deficiency
Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)
We wish to determine to what extent magnesium, thiamine and transketolase activity are affected by the Systemic Inflammatory Response (SIR).
- Conditions
- Inflammation, Magnesium Deficiency, Iron-deficiency, Thiamine Deficiency
- Trial name
- SirTaM (NCT03554668)
- Testing
- Blood draw
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Glasgow Royal Infirmary
Cardiac Surgery, Extracorporeal Circulation; Complications
Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children
Cardiac surgery requires the use of extracorporeal circulation (ECC). Age-related differences in inflammatory response, the greater susceptibility of immature organ systems to injury and the larger ratio of extracorporeal…
- Conditions
- Cardiac Surgery, Extracorporeal Circulation; Complications, Metabolism, Low Cardiac Output
- Trial name
- CardiOGlcNAc (NCT06754709)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital
Obesity, Type 2 Diabetes
Study of Immune Response in Obesity and Type 2 Diabetes
There is a link between activation of the immune response inducing chronic inflammation and both obesity and type 2 diabetes. To date, however, the cause(s) of this inflammation, the mechanisms of the inflammatory cascade and the…
- Conditions
- Obesity, Type 2 Diabetes, Healthy Volunteers
- Trial name
- IMMUNOBEDIA (NCT01907399)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hyperlipidemia, Diet Therapy
Almond Dose Response Study.
To assess the effects of almonds on coronary heart disease (CHD) risk factors (serum lipids, measurements of oxidative stress and nitric oxide production) when added to the diets of subjects with high cholesterol.
- Conditions
- Hyperlipidemia, Diet Therapy, Cardiovascular Disease
- Trial name
- NCT00507520
- Testing
- Full dose almonds, Half dose almonds+half dose muffin, Full dose whole wheat muffin
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Toronto
Diabetes Mellitus Type 2, Insulin Resistance
Modulating the Stress Response in Diabetes Mellitus Type 2 Patients Undergoing Colon Surgery
Background Surgical injury provokes a stress response. These pathways mediated by stress hormones and cytokines cause a catabolic state. The loss of body cell mass may result in prolonged convalescence and increased morbidity.
- Trial name
- NCT02863276
- Testing
- Intensified insulin therapy
- Volunteers
- 18 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Within-subject Variability of NN1250 in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of this clinical trial is to evaluate the variability in the blood glucose-lowering effect of NN1250 (insulin degludec) in subjects with type 1 diabetes.
- Trial name
- NCT00961324
- Testing
- insulin degludec, insulin glargine
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Novo Nordisk A/S
Sepsis, Acute Respiratory Distress Syndrome
Electroacupuncture Modulates SPMs Metabolism and Respiratory Symptoms in Patients With Sepsis Complicating ARDS
In this interventional clinical trial, researchers will administer electroacupuncture versus sham electroacupuncture to sepsis patients with ARDS and collect objective outcome measures. The study will be divided into 2 groups.
- Trial name
- NCT06006325
- Testing
- electroacupuncture treatment
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Tianjin Nankai Hospital
Histologically Confirmed Metastatic or Locally Advanced Breast Cancer With no Radical Topical Treatment Available, If There is Liver Metastasis, Which the Researcher Believes Will be Difficult to Evaluate the Response Accurately With Bone Metastasis or CT
FDG PET-CT in Advanced Breast Cancer
This study is a prospective cohort study comparing metabolic response evaluation by F-18 FDG PET-CT versus conventional imaging for outcome stratification in patients with advanced breast cancer receiving first-line systemic…
- Trial name
- PET-000 (NCT07173868)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Diabetic Macular Edema, Macular Edema Due to Diabetes Mellitus
OCT and OCT-Angiography Biomarkers of Treatment Response to Dexamethasone Implant in Macular Edema Due to Retinal Vascular Diseases - DME and RVO
The purpose of this pilot study is to evaluate different imaging parameters in patients with previously treatment-naive DME and ME due to RVO before and after treatment with dexamethasone implant, in order to find specific…
- Conditions
- Diabetic Macular Edema, Macular Edema Due to Diabetes Mellitus, Retinal Vein Occlusion
- Trial name
- NCT06332690
- Testing
- dexamethasone implant
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Multimedica
Critical Illness
Impact of Supplemental Parenteral Nutrition in ICU Patients on Metabolic, Inflammatory and Immune Responses
Having previously demonstrated that supplemental parenteral nutrition to complete an insufficient enteral nutrition (EN) between D4 and D8 improves outcome after critical illness, by reducing infectious complications, the present…
- Trial name
- SPN2 (NCT02022813)
- Testing
- Supplemental parenteral nutrition (SPN)
- Where
- 2 sites in Switzerland
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obesity, Bariatric Surgery
Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions
The sympathetic nervous (SNS) and the renin angiotensin aldosterone system (RAS) have a direct impact on renal hemodynamic, hormonal secretion and vasoactive peptide.
- Conditions
- Obesity, Bariatric Surgery, Blood Pressure
- Trial name
- OBBYSS (NCT02218112)
- Testing
- bariatric surgery (gastric bypass)
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Morbid Obesity
Metabolic Responses to Bariatric Surgery
Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.
- Trial name
- NCT02024542
- Testing
- Surgery
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of California, Davis
Septic Shock
Urea-to-Creatinine Ratio as a Marker of Metabolic Transition in Septic Shock: A Comparison With Indirect Calorimetry
Urea-to-Creatinine Ratio as a Marker of Metabolic Transition in Septic Shock: A Comparison with Indirect Calorimetry. This study investigates whether the urea-to-creatinine ratio can serve as a simple marker of metabolic state in…
- Trial name
- NCT07412366
- Volunteers
- 40 people
- Sponsor
- Hospital Sao Domingos
Type 2 Diabetes Mellitus
Whey Protein on Posprandial Glucose, Insulin GLP-1, GIP and DPP4 in Type 2 Diabetes
The aim of the present study is to examine the therapeutic effect of whey protein concentrate (WPC 80) in adult subjects with in type 2 diabetes.
- Trial name
- WheyGLP-1 (NCT01571622)
- Testing
- Whey before Breakfast, Water before breakfast
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Tel Aviv University
Binge Eating Disorder, Obesity
Binge Eating Disorder and Obesity : Functional MRI Study
Obesity, defined as BMI> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders.
- Trial name
- BED (NCT02868619)
- Testing
- Functional MRI, ADO-BEDS scale, R-CMAS scale
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Overweight
Exercise for Better Bones - Day or Night?
The purpose of this study is to find out if moderate exercise at different time during the day (early morning vs early evening) affects biomarker CTX of bone health in normal to overweight postmenopausal women.
- Trial name
- NCT05612412
- Testing
- Morning Exercise, Evening Exercise
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Diabetes Mellitus, Quality of Life
Analisys of Neuromuscular Response, Postural Balance and Quality of Life of Diabetics Type 2 After Sensory-motor Training: Blind Random Controled Clinical Trial
Background: The individual's ability to sustain itself in the upright position, effectively adjusting the body's movements and reacting to external stimuli, postural control strategies represent essential activities of daily…
- Conditions
- Diabetes Mellitus, Quality of Life, Exercise Therapy, Postural Balance
- Trial name
- NCT01861392
- Testing
- sensorio-motor training
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Healthy
MitoQ & Cardiopulmonary Responses During Exercise
Study Purpose: To examine the acute effects of antioxidant supplementation on energy use during a single bout of exercise in apparently healthy adult men and women.
- Trial name
- NCT06069245
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ball State University
Nutritional and Metabolic Diseases, Prediabetes
LIfestyle MEtabotype Study A
Glycemic responses vary significantly among individuals, even when consuming identical foods or meals, but the factors predicting individual glucose response to food intake remain poorly investigated.
- Conditions
- Nutritional and Metabolic Diseases, Prediabetes, Type 2 Diabetes
- Trial name
- LIME-A (NCT07868601)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition