Clinical trials: Meropenem
Empirical Antimicrobial Therapy, Critically Ill
Empirical Meropenem Dosing in Critically Ill Patients: Early Assessment of Plasma Exposure and Minimum Inhibitory Concentration Targets
The goal of this prospective cohort study is to characterize meropenem exposure in critically ill adult patients receiving empiric antibiotic treatment in the intensive care unit (ICU).
- Conditions
- Empirical Antimicrobial Therapy, Critically Ill, Meropenem, Pharmacokinetics and Pharmacodynamics
- Trial name
- NCT07681544
- Testing
- Blood extraction
- Where
- Argentina
- Volunteers
- 26 people
- Sponsor
- Hospital Italiano de Buenos Aires
Bloodstream Infections
Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response
Infections of the blood are extremely serious and require intravenous antibiotic treatment. When the infection results from antibiotic resistant bacteria, the choice of antibiotic is an extremely important decision.
- Trial name
- MERINO II (NCT02437045)
- Testing
- Meropenem, Piperacillin-tazobactam combination product
- Where
- 6 sites in Australia, Singapore
- Volunteers
- 100 people
- Sponsor
- The University of Queensland
Drug Safety
Ertapenem Versus Meropenem/Imipenem for ESBL+ Gram-negative Infections
Adult patients with ESBL-producing Gram negative infections are randomized to receive ertapenem or meropenem/imipenem. Clinical and microbiological responses between both groups are compared.
- Trial name
- NCT01297842
- Testing
- Ertapenem, Meropenem or Imipenem
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Critical Illness, Bacterial Infections
PK/PD and Clinial Outcomes of Beta-lactams in ICU Patients
Meropenem and imipenem are broad-spectrum carbapenem antibiotic and are frequently prescribed in critically ill patients with severe infections.
- Trial name
- NCT03858387
- Testing
- Meropenem, Imipenem
- Where
- Thailand
- Volunteers
- 102 people
- Sponsor
- Prince of Songkla University
Tuberculosis, Pulmonary
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB
The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M.
- Trial name
- NCT03174184
- Testing
- Rifampin, MEROPENEM 2 grams TID, MEROPENEM 1 gram TID
- Where
- South Africa
- Volunteers
- 112 people
- Sponsor
- Johns Hopkins University
Acute Pyelonephritis, Complicated Urinary Tract Infection
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Meropenem-Vaborbactam in Children With Complicated Urinary Tract Infection, Including Acute Pyelonephritis
The primary objective of the study is to assess the safety and tolerability of meropenem-vaborbactam administered by intravenous (IV) infusion in children 3 months and above to less than 12 years with complicated urinary tract…
- Trial name
- NCT06672978
- Testing
- Meropenem-Vaborbactam, Antibiotics
- Where
- 26 sites in United States, Bulgaria and 4 more
- Volunteers
- 66 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, LLC)
Obesity
Pharmacokinetics of Carbapenem Antibiotics in Obese Patients.
Tissue kinetics of ertapenem and meropenem in fatty tissue, intraperitoneal fluid and plasma.
- Trial name
- NCT01407965
- Testing
- microdialysis catheter
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- University of Ulm
Infections
Antimicrobial De-escalation Strategy in Medical Patients
The purpose of this pilot study is to assess the impact of an antibiotic de-escalation strategy on the clinical outcomes (clinical cure or improvement) of medical patients related to the usage of of broad-spectrum antimicrobial…
- Trial name
- NCT01066013
- Testing
- Antimicrobial de-escalation strategy
- Volunteers
- 100 people
- Sponsor
- Fraser Health
Ventilator-associated Bacterial Pneumonia
Trial of Colistin Versus Meropenem in Ventilator-associated Pneumonia (VAP) (CR-GNB)
1. To demonstrate that colistin iv. is not inferior to meropenem in empiric treatment of VAP regarding the final point of primary efficacy: mortality in the 28 subsequent days and clinical healing in patients clinically…
- Trial name
- MagicBullet (NCT01292031)
- Testing
- Colistin, Meropenem
- Where
- 33 sites in Greece, Italy and 1 more
- Volunteers
- 232 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Cystic Fibrosis, Pneumonia
Population Pharmacokinetics of Prolonged Infusion Meropenem in Cystic Fibrosis (CF) Children
This study will determine the concentrations of the antibiotic meropenem when administered as a 3 hour prolonged infusion in children with cystic fibrosis who are hospitalized with an acute pulmonary exacerbation.
- Conditions
- Cystic Fibrosis, Pneumonia, Pseudomonas Aeruginosa Infection
- Trial name
- NCT01429259
- Testing
- meropenem
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Joseph Kuti
Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)
Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in Carbapenem-Resistant Enterobacteriaceae Infections
The study will evaluate the efficacy and safety of Meropenem and Pralurbactam versus Best Available Therapy in the treatment of Carbapenem-Resistant Enterobacteriaceae Infections.
- Conditions
- Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP), Complicated Intra-abdominal Infection (cIAI), Complicated Urinary Tract Infection (cUTI)
- Trial name
- NCT07089186
- Testing
- Meropenem and Pralurbactam, Best Available Therapy (e.g., colistin, meropenem, tegecycline, amikacinceftezidime-avibatam)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Acute-On-Chronic Liver Failure
Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.
Acute on chronic liver failure patients are at high risk for nosocomial infections due to liver dysfunction, which impairs immune responses and increases vulnerability to infections.
- Trial name
- NCT06818565
- Testing
- Meropenem Injection, Ceftazidime-avibactam, Teicoplanin
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Pharmacokinetics, Amoxicillin-clavulanate
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- PADECMO (NCT06426836)
- Testing
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Where
- 3 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- University Hospital, Ghent
Septic Shock
Meropenem and Ciprofloxacin Dosing in Septic Shock
Patients with septic shock may have altered volume of distribution and metabolism of antibiotics which are crucial medications for treating infections.
- Trial name
- NCT02240277
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Beta-lactam Antibiotics, Therapeutic Drug Monitoring
The OPTIMAL TDM Study: Determining Optimal Beta-lactam Plasma Concentrations Through Therapeutic Drug Monitoring
Little is known of beta-lactam antibiotics' true therapeutic plasma concentration range. The aims of this study are to define evidence-based, safe and effective upper and lower limits of the plasma concentrations of imipenem…
- Conditions
- Beta-lactam Antibiotics, Therapeutic Drug Monitoring, Toxicity, Efficacy
- Trial name
- OPTIMAL TDM (NCT03790631)
- Testing
- The study is observational.
- Where
- Switzerland
- Volunteers
- 771 people
- Sponsor
- University of Geneva, Switzerland
Lower Respiratory Tract Infection
Approach for Optimizing Meropenem Therapy in Intubated and Mechanically-Ventilated, Adult Patients With Severe Gram-Negative Lower Respiratory Tract Infection
Antibacterial drugs are facing increasing limitations in terms of effectiveness due to emergence resistance. Improved antibacterial drug monitoring approaches are particularly needed in nosocomial infections occurring in ICU…
- Trial name
- MON4STRAT (NCT03915236)
- Testing
- MON4STRAT Strategy, Control group
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 7 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Cystic Fibrosis Pulmonary Exacerbation
Pharmacokinetic Study of Extended Infusion Meropenem in Adult Cystic Fibrosis Patients
Meropenem is an intravenous antibiotic commonly used to treat acute exacerbation of respiratory infections in cystic fibrosis. The research study aims to determine if a different method of infusing the drug over 3 hours or…
- Trial name
- NCT01158937
- Testing
- Meropenem Infusion
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Unity Health Toronto
Infection, Acute Kidney Injury
The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)
The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections.
- Conditions
- Infection, Acute Kidney Injury, Sepsis
- Trial name
- VPS (NCT07556107)
- Testing
- Piperacillin + Tazobactam, meropenem
- Where
- 7 sites in United States
- Volunteers
- 852 people
- Sponsor
- Bassett Healthcare
Antibiotic Resistant Infection, Critical Illness
Bolus Versus Continuous Infusion of Meropenem
This study arises from the need to optimize antibacterial drug usage to face increasing drug resistance among gram-negative pathogens in intensive care units.
- Trial name
- MERCY (NCT03452839)
- Testing
- Meropenem
- Where
- 26 sites in Croatia, Italy and 2 more
- Volunteers
- 607 people
- Sponsor
- Università Vita-Salute San Raffaele
Elderly Infection
Population Pharmacokinetics and Dosage Individualization of Antibiotics in Elderly Patients
The investigator's purpose is to study the pharmacokinetics and pharmacodynamics of biapenem,meropenem,piperacillin and tazobactam,tigecycline,levofloxacin.etc in elderly ICU patients and recommend an individual dosage regimen of…
- Trial name
- NCT04799626
- Testing
- biapenem,meropenem,piperacillin and tazobactam,tigecycline,levofloxacin.etc
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University