Clinical trials: Mental Well-being
Autism, Trauma
A Pilot Participatory Program Evaluation of a Virtual Trauma Support Program for Autistic Adults
The goal of this single-group clinical trial is to learn about the initial efficacy and feasibility of telehealth-delivered Written Exposure Therapy (WET) for autistic adults with traumatic stress symptoms.
- Conditions
- Autism, Trauma, Posttraumatic Stress Disorder, Posttraumatic Stress Symptom
- Trial name
- NCT05862467
- Testing
- Written Exposure Therapy (WET) via telehealth
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Wyoming
Alcoholism
Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics
This is a randomized, placebo controlled trial of dietary zinc and S-adenosylmethionine (SAMe) in otherwise healthy alcoholic US Veterans.
- Trial name
- ExZACTO (NCT01899521)
- Testing
- Bronchoscopy, Zinc sulfate 220 mg once daily, S-adenosylmethionine 400 mg twice daily
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- VA Office of Research and Development
Mental Health Disorder
Arena Labs - Improving Clinician Well Being
To determine the efficacy of the asynchronous performance coaching platform, Arena Strive at changing measures of physiological resilience, professional fulfillment, burnout, and self-valuation in full time clinicians.
- Trial name
- NCT05653700
- Testing
- Arena Strive, Control Cohort
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Nicotine Dependence
Trial on the Effectiveness of Mindfulness Training for Smokers
The Mindfulness Training for Smokers study follows a randomized controlled design with 240 total participants. Both the study group and the control group will be enrolled in the Wisconsin Tobacco Quit Line and will receive four…
- Trial name
- MTS (NCT01093599)
- Testing
- Quit Line plus MTS, Quit Line Only
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Wisconsin, Madison
Substance Use Disorders, HIV
Implementing Technology-Assisted Drug Treatment and Relapse Prevention in Federally Qualified Health Centers (FQHCs)
Implementing a mobile-phone based system for drug use disorders in primary care settings.
- Trial name
- Seva (NCT01963234)
- Testing
- Seva
- Where
- 3 sites in United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Dementia, Alzheimer Disease
Community-based Brain Health Program to Address Dementia Risk
This is a validation study to evaluate the acceptability, feasibility and preliminary efficacy of the Brain Health Program, a multimodal curriculum covering dementia risk factors and evidence-based change interventions.
- Trial name
- C-BBHP (NCT05529706)
- Testing
- Brain Health Program
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Posit Science Corporation
Stress, Carer Stress Syndrome
Tailored Health Self-Management Interventions for Highly Distressed Caregivers: Family Members of Persons With Dementia
How do different health self-management interventions (resourcefulness training or biofeedback training) compare to usual care (dementia education) in affecting the health risks, and physical and mental health, of family…
- Conditions
- Stress, Carer Stress Syndrome, Dementia, Alzheimer Disease
- Trial name
- NCT04247347
- Testing
- Biofeedback Training, Dementia Education, Resourcefulness Training
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Depression
Effects of Adding Motivational Interviewing to Antidepressant Treatment for Hispanic Adults With Depression
This study will evaluate the effectiveness of adding motivational interviewing to antidepressant treatment for major depressive disorder in Hispanic adults.
- Trial name
- NCT00564278
- Testing
- Standard antidepressant therapy (SADT), Motivational antidepressant therapy (MADT)
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Opioid Dependence
SMART Effectiveness Trial
The current study piloted two psychosocial interventions developed to increase buprenorphine-naloxone adherence in individuals with opioid use disorder (OUD).
- Conditions
- Opioid-use Disorder, Opioid Dependence, Treatment Adherence
- Trial name
- NCT04464421
- Testing
- Contingency Management (CM), Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Karen Derefinko, PhD
Mental Disorders
A Randomized Controlled Trial of Mental Health Peer-Led Education
This randomized controlled trial tests the efficacy of a mental health peer-led educational intervention called BRIDGES (Building Recovery of Individual Dreams and Goals through Education and Support).
- Trial name
- BRIDGES (NCT01297985)
- Testing
- BRIDGES Peer-Led Education
- Where
- United States
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Burnout, Mental Health
Mindful Hand Hygiene for Healthcare Workers
The purpose of this study is to test an intervention focused towards promoting mindfulness among VA physicians and nurses. Mindfulness is a tool that can help people focus. It helps clear the mind of distractions and biases.
- Trial name
- NCT05261282
- Testing
- Mindful Hand Hygiene
- Where
- 2 sites in United States
- Volunteers
- 343 people
- Sponsor
- VA Office of Research and Development
Tobacco, Posttraumatic Stress Disorder
Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence
Veterans with PTSD have high rates of smoking (34%-86% vs. 18% in the general population) and have substantial difficulties with quitting tobacco.
- Trial name
- ACT-PT (NCT02576899)
- Testing
- Acceptance and Commitment Therapy for PTSD and Tobacco Use, Freedom From Smoking
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Mental Health Wellness 1
Evaluation of the Aevidum Curriculum and Club
The study purpose is to evaluate the effectiveness of the Aevidum curriculum (plus/minus club) to improve adolescent mental health knowledge, help-seeking intentions, and school culture.
- Trial name
- NCT05018689
- Testing
- Aevidum curriculum, Club
- Where
- United States
- Volunteers
- 2,557 people
- Sponsor
- Milton S. Hershey Medical Center
Opioid-use Disorder, Opioid Dependence
Comparing Two Training Methods for Opioid Wizard
The prevalence of opioid use disorder (OUD) and opioid-related deaths has risen dramatically in recent years. Effective treatments, including medications for opioid use disorder (MOUDs; e.g., buprenorphine-naloxone and methadone)…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Attitude of Health Personnel
- Trial name
- NCT04867382
- Testing
- Online training
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- HealthPartners Institute
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Visual Rehabilitation, Visual Impairment, Autism Spectrum Disorder, Developmental Disabilities, Intellectual Disability, Behavioral Symptoms
Evaluation of a Program to Enhance Ophthalmic Compliance in Children and Adolescents With Special Needs
The goal of this clinical trial is to learn about the effects of the structured program incorporating contextual, behavioral, and cognitive strategies to improve compliance of children and adolescents with special needs during…
- Trial name
- NCT06717282
- Testing
- visual rehabilitation for ophthalmic compliance, Using contextual, behavioral, and cognitive-based stragegies to develop training programs
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Clinical Decision Support, Buprenorphine
Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
Emergency Departments (EDs) frequently care for individuals with Opioid Use Disorder (OUD). Buprenorphine (BUP) is an effective treatment option for patients with OUD that can safely be initiated in the ED.
- Conditions
- Clinical Decision Support, Buprenorphine, Opioid-use Disorder
- Trial name
- EMBED (NCT03658642)
- Testing
- Clinical Decision Support (CDS)
- Where
- 22 sites in United States
- Volunteers
- 5,047 people
- Sponsor
- Yale University
Anxiety State, Satisfaction
Immersive Virtual Reality Exposure for Reducing Preoperative Anxiety in Children
Perioperative anxiety management for children undergoing surgery poses a major challenge to anaesthesiologists as high anxiety, reported in numerous studies, leads to detrimental effects physiologically, mentally and on pain…
- Conditions
- Anxiety State, Satisfaction, Compliance
- Trial name
- NCT07018999
- Testing
- Immersive virtual reality operating theatre tour
- Where
- Hong Kong
- Volunteers
- 114 people
- Sponsor
- Hong Kong Children's Hospital
Substance Use Disorders
Women Veterans' Substance Abuse Treatment
The purpose of this study is to examine the efficacy of a gender-focused addiction treatment model (A Woman's Path to Recovery) versus a non-gender focused addiction treatment model (12-Step Facilitation) in a sample of women…
- Trial name
- NCT00734903
- Testing
- A Woman's Path to Recovery, 12-Step Facilitation
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Depression
An eHealth Intervention to Increase Depression Treatment Initiation and Adherence Among Veterans Referred for Mental Health Services
Depression is the most prevalent mental health condition among VHA patients and is strongly associated with poor functioning, negative health outcomes, and suicide.
- Trial name
- NCT05990075
- Testing
- self-monitoring
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development