Clinical trials: Menopause
Quality of Life and Menopause
Effects of Chi Kung to Improve the Symptoms of Menopause
To analyze the effects of a Chi Kung exercise program in Spanish menopausal women
- Trial name
- NCT03989453
- Testing
- Chi Kung
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Jaén
Vasomotor Symptoms
The Effect Of Dose Titration And Dose Tapering On The Tolerability Of DVS SR In Women With Vasomotor Symptoms
Desvenlafaxine succinate (DVS SR) is a serotonin and norepinephrine reuptake inhibitor (SNRI). It is a nonhormonal option for the treatment of Vasomotor Symptoms (VMS) associated with menopause.
- Trial name
- NCT00401245
- Testing
- desvenlafaxine succinate sustained release
- Where
- 74 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- Pfizer
Osteoporosis
Assessment of Anti-RANKL Antibody in Post-menopausal Women
This is a single-center, open-label, dose-escalating study to evaluate the safety, pharmacokinetics, immunogenicity, and preliminary efficacy of single dose subcutaneous injection of a fully human monoclonal antibody of receptor…
- Trial name
- NCT03242512
- Testing
- TK006
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu T-Mab Biopharma Co.,Ltd
Postmenopausal Symptoms, Aging
Cholinergic Health After Menopause (CHAMP)
Women are at increased risk for Alzheimer's disease (AD). Notably at menopause, some women experience a change in cognition. However, not all women experience negative effects of menopause on cognition.
- Conditions
- Postmenopausal Symptoms, Aging, Alzheimer Disease
- Trial name
- CHAMP (NCT04129060)
- Testing
- Cholinergic antagonist
- Where
- 2 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Postmenopausal Female Patients, Vasomotor Symptoms
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females on Hormone Therapy
This study is examining whether short-term supplementation with inorganic nitrate in the form of beetroot juice can enhance vascular function in postmenopausal females taking hormone therapy compared to placebo.
- Conditions
- Postmenopausal Female Patients, Vasomotor Symptoms, Menopausal Hormone Therapy
- Trial name
- BEET-MHT (NCT07871396)
- Testing
- Moderate Intensity Exercise (MIE), High intensity exercise (HIE), Control (No exercise)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Breast Cancer
Survey in Post-menopausal Women Followed up After Treatment With Anastrozole as Adjuvant Therapy
The purpose of this survey is to describe long-term tolerance as seen under current conditions of use for anastrozole.
- Trial name
- ARIES (NCT00542594)
- Volunteers
- 1,840 people
- Sponsor
- AstraZeneca
Breast Cancer
A Trial Using ARV-471 or Anastrozole in Post-Menopausal Women With Breast Cancer Prior to Surgery
This trial is a Phase 2 neoadjuvant study evaluating ARV-471 or anastrozole in post-menopausal women with estrogen receptor positive/ human epidermal growth factor receptor 2 (ER+/HER2)- localized breast cancer.
- Trial name
- NCT05549505
- Testing
- ARV-471, Anastrozole, Surgical resection of breast tumor
- Where
- 49 sites in United States, Georgia and 2 more
- Volunteers
- 152 people
- Sponsor
- Arvinas Inc.
Healthy, Premature Ovarian Failure
Feasibility Study for Development of an Early Test for Ovarian Failure
This purpose of this study is to gain information about normal ovarian function that will be useful in developing a test for early detection of ovarian failure.
- Trial name
- NCT00006156
- Testing
- Control, Drug: FSH
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy
Bioequivalence Study of Fulvestrant Injection 50 mg/mL in Healthy Post-menopausal Female Subjects
The purpose of this study is to demonstrate bioequivalence between the test drug product, fulvestrant Injection, 50 mg/mL, and the Reference Listed Drug, Faslodex® Injection, 50 mg/mL.
- Trial name
- NCT02795039
- Testing
- Fulvestrant
- Where
- 3 sites in Canada
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi
Perimenopause, PMDD
Transcutaneous Auricular Neurostimulation (tAN) for Premenstrual Dysphoric Disorder (PMDD) and Perimenopause
Transcutaneous Auricular Neurostimulation (tAN) will be administered to women with premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and perimenopause.
- Trial name
- NCT07688720
- Testing
- transcutaneous auricular neurostimulation (tAN)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Texas Christian University
Hypertension, Menopause, Premature
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women.
- Conditions
- Hypertension, Menopause, Premature, Menopause, Blood Pressure
- Trial name
- NCT04439370
- Testing
- Microneurography to measure muscle sympathetic nerve activity (MSNA), Baroreflex sensitivity testing, Sympathoexcitatory Maneuvers
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Coronary Artery Disease, Menopause
Serum Concentration of Endogenous Estrogens and Sirtuin-1 After Administration of Atorvastatin and Quercetin:
Chronic coronary syndrome (CCS) is the leading cause of death in women in the most developed regions of Brazil. The primary etiopathogenic mechanism is the process of atherosclerosis.
- Trial name
- NCT05877235
- Testing
- Quercetin
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- InCor Heart Institute
Vasomotor Symptoms
Effect of Yoga on Objective and Subjective Menopausal Hot Flashes
The purpose of this research study is to compare yoga and health and wellness classes for helping perimenopausal or newly postmenopausal women who are experiencing hot flashes.
- Trial name
- GLAM (NCT01073397)
- Testing
- Yoga
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Post Menopausal
The Impact of Inorganic Nitrate-rich Beetroot Juice on Microvascular Blood Flow and Cognitive Function
Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide. Inorganic nitrate found in beetroot and green leafy vegetables has been demonstrated to reduce cardiovascular disease risk factors including…
- Trial name
- NCT05810974
- Testing
- Concentrated beetroot juice, Nitrate depleted beetroot juice + potassium nitrate (KNO3), Nitrate depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Reading
Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer
BYL719 and Letrozole in Post-Menopausal Patients With Hormone Receptor-Positive Metastatic Breast Cancer
This phase I trial studies the side effects and best dose of the PI3K inhibitor BYL719 when given together with letrozole in treating patients with hormone receptor-positive metastatic breast cancer.
- Conditions
- Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer, Invasive Ductal Breast Carcinoma, Progesterone Receptor-positive Breast Cancer
- Trial name
- NCT01791478
- Testing
- PI3K inhibitor BYL719, letrozole, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Menopause Related Conditions
Low-level Laser Therapy in Genitourinary Symptoms of Menopause
The study will employ a prospective single-arm design involving menopausal women who present with genitourinary symptoms of menopause (GSM).
- Trial name
- NCT06074120
- Testing
- Low-level laser therapy
- Where
- Taiwan
- Volunteers
- 27 people
- Sponsor
- National Taiwan University Hospital
Menopausal Symptoms
Efficacy of CL22205 on Bone Mineral Density and Menopausal Symptoms
The purpose of this study is to evaluate the effect of CL22205 on bone mineral density and menopausal symptoms in women.
- Trial name
- NCT06899243
- Testing
- CL22205
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Eetho Brands, Inc
Genitourinary Syndrome of Menopause
Impact of Oral Supplementation With Bioactive Collagen Peptides and Other Functional Ingredients
Genitourinary Syndrome of Menopause (GSM), characterized by vaginal dryness, pain, urinary incontinence, and other symptoms, can be mitigated through both hormonal and non-hormonal treatments.
- Trial name
- Maicol (NCT07151482)
- Testing
- Collagendep
- Volunteers
- 43 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Post Menopausal Breast Cancer
Study in Post-menopausal Women With Hormone Receptor Positive, HER2-negative Advanced Breast Cancer
This international, multi-center, open-label, single-arm study evaluated the safety and tolerability profile of everolimus in post-menopausal women with HR positive, HER2 negative locally advanced or metastatic breast cancer…
- Trial name
- EVEREXES (NCT03176238)
- Testing
- everolimus, exemestane
- Where
- 55 sites in Australia, India and 11 more
- Volunteers
- 235 people
- Sponsor
- Novartis Pharmaceuticals
Perimenopause, Menopause
CARAMEL Observational Study
CARAMEL is a project funded by the European Commission under the Horizon Europe programme. Its aim is to develop a personalized prevention approach based on state-of-the-art artificial intelligence models for cardiovascular risk…
- Conditions
- Perimenopause, Menopause, Cardiovascular (CV) Risk, Women (Between 30 to 60 Years Old)
- Trial name
- CARAMEL-OS (NCT07695376)
- Where
- 6 sites in Colombia, Croatia and 3 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute