Clinical trials: Menopausal Syndrome
Postmenopausal Vulvovaginal Atrophy
Evaluating the Efficacy of Temperature-controlled Radiofrequency (TRF) in the Treatment of Vulvovaginal Atrophy.
This project will be a prospective, multicenter, randomized cohort study. The investigators will select patients with vulvovaginal atrophy who have indications for treatment, and set up the experimental group (Peninsula…
- Trial name
- NCT04657536
- Testing
- high frequency fulguration equipment, promestriene vaginal soft capsules
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Menopause, Vasomotor; Syndrome
Efficacy of Nano-Pso Therapy in Menopause
Vasomotor syndrome is prevalent in 85% of postmenopausal women, hormone therapy in menopause is first-line therapy, but 38% of patients have some contraindication for its use.
- Trial name
- NCT06432816
- Testing
- NANO-PSO
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Distribuidora Biolife SA de CV
Atrophy;Vaginal, Breast Cancer
Light Emitting Diode for theTreatment of Genitourinary Syndrome of Menopause Associated With Breast Cancer Treatment
Breast Cancer treatment may cause several side effects, some long lasting. Adjuvant hormone therapy helps avoiding recurrence triggers vulvovaginal atrophy syndrome.
- Trial name
- LEDCA (NCT03833726)
- Testing
- Experimental: LED group
- Where
- Brazil
- Volunteers
- 77 people
- Sponsor
- Centro de Atenção ao Assoalho Pélvico
Coronary Artery Disease (CAD), Menopause
Serum Endogenous Estrogens, Estrogen Receptors, and Sirtuin-1 and -3 After Resveratrol Supplementation
Atherosclerotic coronary artery disease (CAD) is a leading cause of mortality among postmenopausal women. Resveratrol, a phenolic compound with antioxidant properties, may influence lipid metabolism, endothelial function, and…
- Conditions
- Coronary Artery Disease (CAD), Menopause, Hormones
- Trial name
- RESEARCH (NCT07865377)
- Testing
- Trans-resveratrol, 1000 mg daily for 90 days
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- InCor Heart Institute
Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness
To Assess Signs and Symptoms in Women Affected by GSM After One Cycle of Pixel CO2-Alma Fractionated Laser
Genitourinary syndrome of menopause (GSM) occurs in approximately 50% of menopausal women but is both underrecognized and undertreated despite numerous treatment options.
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness, Burning, Pain
- Trial name
- NCT05156502
- Testing
- Fractionated Laser (Pixel CO2-Alma), Fractionated Laser (Pixel CO.2-Alma)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dr. Filippo Murina
Metabolic Syndrome, Menopause
Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome
The objective of this project is to provide evidence that L-Citrulline (CIT) supplementation can improve vascular function in the fasted and acute hyperglycemia conditions in middle-aged and older women with metabolic syndrome.
- Trial name
- NCT06025357
- Testing
- L-Citrulline supplementation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Menopausal Syndrome, Cardiovascular Disease
Multi-centre Clinical Trial on Hormone Replacement Treatment in China
This study is to evaluate the benefit/risk of hormone replacement treatment among early menopausal women in China. This is a multi-centre, random, prospective study.
- Conditions
- Menopausal Syndrome, Cardiovascular Disease, Osteoporosis, Breast Cancer
- Trial name
- NCT01698164
- Testing
- estradiol plus MPA, Ximingting Tablet, estradiol plus progesterone
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Peking Union Medical College Hospital
HIV/AIDS, Menopause
Role of Exogenous and Endogenous Sex Hormones on Tenofovir and Emtricitabine Disposition in Female Genital Tract
Cervical biopsies will be collected from women aged 18 and over whom are virally suppressed and taking tenofovir as part of their antiretroviral therapy regimen.
- Conditions
- HIV/AIDS, Menopause, Inflammation Vagina
- Trial name
- NCT03218085
- Testing
- Tenofovir, Emtricitabine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Minnesota
Postmenopausal Syndrome
Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism
Estrogen and progesterone are two main female sex hormones. When a woman goes through menopause, the body's production of estrogen and progesterone significantly decreases.
- Trial name
- Estrogen (NCT00565916)
- Testing
- Estrogen, Progesterone
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Menopausal Syndrome
Efficacy and Safety of Traditional Chinese Medicine Intervention for Women With Menopausal Syndrome
The purpose of this multiple-centered, randomized, controlled study is to investigate the efficacy and safety of a combination using herbs prescription and traditional Chinese medicine (TCM) emotion treatment in women with…
- Trial name
- NCT00933725
- Testing
- TCM intervention, Western intervention
- Where
- 8 sites in China
- Volunteers
- 194 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Genitourinary Syndrome of Menopause (GSM), Bacterial Vaginosis
Photobiomodulation for Vaginal Dysfunctions: Home-Based vs Outpatient Treatment
Vaginal disorders, including vulvovaginal candidiasis (VVC), bacterial vaginosis (BV), and genitourinary syndrome of menopause (GSM), are highly prevalent conditions that significantly affect women's quality of life and sexual…
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Bacterial Vaginosis, Vulvovaginal Candidiasis (VVC)
- Trial name
- NCT07697768
- Testing
- Blue LED Photobiomodulation
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Patricia Lordelo
Breast Cancer Female, Genitourinary Syndrome of Menopause
MonaLisa Laser Intervention for Post-Menopausal Breast Cancer Patients: A SHE CAN Study
The purpose of this study is to assess the efficacy of a fractional CO2 laser ("SmartXide2 - V2LR", DEKA M.E.L.A., Florence - Italy) "the Laser" in the treatment of genitourinary symptoms of menopause, female sexual function, and…
- Trial name
- NCT04606550
- Testing
- Microablative Fractional CO2 Laser Therapy
- Sponsor
- Mount Sinai Hospital, Canada
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
A Study to Learn What Happens to Elinzanetant in the Body When Taken With or Without Carbamazepine, and How Safe it is in Healthy Men and Women Aged 18 to 60 Years.
Researchers are looking for a better way to treat people who have symptoms caused by hormonal changes, such as hot flashes. Before a treatment can be approved for patients to take, researchers do clinical studies to better…
- Trial name
- NCT05028608
- Testing
- Elinzanetant (BAY3427080), Midazolam, Carbamazepine
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Climacteric Syndrome, Menopause
Pharmacokinetic Aspects of 25-mg Estradiol Pellet in Climacteric Women
A single center, prospective, open-label clinical study will be conducted, to monitor serum concentration and pharmacokinetic profile after subcutaneous implantation of a 25mg-estradiol bioabsorbable implant in postmenopausal…
- Conditions
- Climacteric Syndrome, Menopause, Hypoestrogenism
- Trial name
- CLARA (NCT06136208)
- Testing
- s.c 25 mg estradiol pellet
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Science Valley Research Institute
Climacteric Syndrome
Efficacy and Safety of Passiflora Incarnata and Isoflavona Combination in the Treatment of Climacteric Symptoms
The purpose of this study is to evaluate the effects of Passiflora incarnata and Isoflavone combination in relieving the symptoms associated with Climacteric Syndrome.
- Trial name
- Monalisa (NCT01695616)
- Testing
- Active drug
- Where
- Brazil
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Vaginal Atrophy
Comparative Study: Vaginal Promestriene Use, Fractional CO2 LASER and Radiofrequency in the Vaginal Atrophy Treatment
Postmenopausal hypoestrogenism may determine genital atrophy, which may be accompanied by a non-specific inflammatory process and may hinder or even prevent sexual intercourse.
- Trial name
- NCT04717245
- Testing
- Promestriene Vaginal, Fractional CO2 LASER, Microablative Fractional radiofrequency
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Sao Paulo General Hospital
Female Infertility Due to Diminished Ovarian Reserve, Menopausal Syndrome
Cohort Study to Evaluate Ovarian Function
The study will collect the clinical and biological data of the patients, the investigators could further analyse and identify the risk factors and optimize clinical treatment method.
- Conditions
- Female Infertility Due to Diminished Ovarian Reserve, Menopausal Syndrome, Sexual Function and Fertility Disorders, Cardiovascular Diseases
- Trial name
- NCT02294500
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shixuan Wang
Menopause
RCT on the Treatment of Menopausal Syndrome With Chinese Medicine
This is a double-blinded, randomized, placebo-controlled clinical trial. Subjects will be randomly assigned to the treatment group (Modified Guizhi Fuling granules) or placebo group (Placebo granules) for 8 weeks.
- Trial name
- NCT06074809
- Testing
- Modified Guizhi Fuling granules
- Where
- Hong Kong
- Volunteers
- 78 people
- Sponsor
- Chinese University of Hong Kong
Recurrent Urinary Tract Infection, Postmenopause
Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women
Urinary tract infections (UTIs) are bothersome and more likely to occur in postmenopausal women. Frequent UTIs, as well as other problems with the urinary and genital systems such as painful sex and urinary frequency/urgency, are…
- Conditions
- Recurrent Urinary Tract Infection, Postmenopause, Postmenopausal Syndrome, Postmenopausal Symptoms
- Trial name
- NCT03854396
- Testing
- Prasterone
- Where
- United States
- Sponsor
- Olivia Cardenas-Trowers, M.D.
Menopause Syndrome
The Benefits and Risks of Different Menopausal Hormone Replacement Therapy Regimes in the Treatment of Menopause Syndrome
A prospective, open-label, randomized controlled clinical trial to compare the benefits and risks of half-dose or standard-dose conjugated equine estrogens(CEE) plus natural progesterone or dydrogesterone in menopausal hormone…
- Trial name
- NCT03436303
- Testing
- CEE 0.625 mg/MP 100mg, CEE 0.3 mg/MP 100mg, CEE 0.625mg/dydrogesterone
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital