Clinical trials: Memory Disorders
Alzheimer's Disease, Mild Cognitive Impairment
BEAM: Brain-Eye Amyloid Memory Study
The main objectives for this study are: 1. To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Vascular Cognitive Impairment, Parkinson's Disease
- Trial name
- BEAM (NCT02524405)
- Testing
- Pittsburgh Compound B [11C]-PIB
- Where
- 5 sites in Canada
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Lifestyle Risk Reduction
EMuNI Project: Multiple Nonpharmacological Interventions
By 2030, the global prevalence of Alzheimer's Disease (AD) is predicted to reach 65.7 million worldwide. Despite extensive research efforts, a cure for AD has not been identified.
- Trial name
- EMuNI (NCT03382353)
- Testing
- Nutritional supplementation, Educational training, Counselling on a brain-healthy diet
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Sedentary Time, Insomnia
mPATH for Low-income Older Adults
Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults.
- Conditions
- Sedentary Time, Insomnia, Cognitive Decline
- Trial name
- NCT05935241
- Testing
- mPATH, Attention Control
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Amnesia
Transient Global Amnesia (TGA). Exploratory Study of the Default Mode Network During the Acute Phase
The transient global amnesia, in which the memory disorder is massive, transient and pure, offers a unique model for exploring episodic memory.
- Trial name
- ICTUS (NCT02010853)
- Testing
- IRMf
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Varicella Zoster Virus Infection
VZV-specific Tissue Resident Memory T-cells After Shingrix Vaccination
To evaluate the effect of intramuscular RZV vaccine on VZV-specific skin TRM and circulating T-cells
- Trial name
- NCT04403139
- Testing
- Shingrix
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
ADHD
Study of ADHD Children's Sensitivity to Memory Error Production
The purpose of the study is to test whether children with Attention Deficit/Hyperactivity Disorder (ADHD) are more susceptible to false memory production using a DRM paradigm.
- Trial name
- TDAH-DRM (NCT05365295)
- Testing
- DRM (Deese, Roediger et McDermott task)
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Angers
Depression
Problem Adaptation Therapy (PATH) vs. Supportive Therapy in Treating Depressed, Cognitively Impaired Older Adults
This study will evaluate the efficacy of Problem Adaptation Therapy (PATH) vs. Supportive Therapy for Cognitively Impaired (ST-CI) older adults in reducing depression and disability in treating depressed, cognitively impaired…
- Trial name
- NCT00368940
- Testing
- PATH, ST-CI
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Weill Medical College of Cornell University
Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma
CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma
This phase 2 trial studies how well cluster of differentiation 8 (CD8)+ memory T-cells work as a consolidative therapy following a donor non-myeloablative hematopoietic cell transplant in treating patients with leukemia or…
- Conditions
- Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin Lymphoma
- Trial name
- NCT02424968
- Testing
- Anti-Thymocyte Globulin, Cyclosporine, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Robert Lowsky
Relapsed/Refractory Large B-cell Lymphoma (LBCL), Diffuse Large B-Cell Lymphoma (DLBCL)
A Phase Ib/II Exploratory Clinical Trial of Memory-Enhanced 7×19-THEMIS CAR-T Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma
This study is aimed to explored the safety and efficacy of 7×19-THEMIS CAR-T cell therapy for large B-cell lymphoma and to conduct an exploratory comparison of the 3-month objective response rate (ORR) and complete remission rate…
- Conditions
- Relapsed/Refractory Large B-cell Lymphoma (LBCL), Diffuse Large B-Cell Lymphoma (DLBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), Transforming Follicular Lymphoma (tFL)
- Trial name
- NCT07788118
- Testing
- 7×19-THEMIS CAR-T cells
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer Disease, Dementia
A Mobile Informatics Solution to Aid in Memory
The researchers propose to develop an informatics system to assist people with memory impairment. Persons with Memory Concern (PWMC) recognize the faces they see daily, such as a spouse or caregiver, but they may confuse visiting…
- Trial name
- NCT04700540
- Testing
- Smartwatch Reminder (SR) system
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Working Memory, Epilepsy
Modulating Oscillations and Working Memory in Patients With Subdural Electrodes
Purpose: To investigate whether rhythmic direct electrical stimulation (DES) causes entrainment of endogenous neural oscillatory activity and whether such activity improve cognition.
- Trial name
- NCT03111290
- Testing
- Direct Cortical Stimulation
- Sponsor
- University of North Carolina, Chapel Hill
Impulsive Behavior, Mental Disorders
Cognitive Control Training for Urgency in a Naturalistic Clinical Setting
This study is designed to test whether computer-based cognitive exercises are helpful for reducing a specific type of impulsivity.
- Trial name
- NCT03527550
- Testing
- Cognitive Control Training
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Multiple Sclerosis (MS)
Pilot of the Virtual Memory Attention and Problem Solving Skills Intervention for Persons With Multiple Sclerosis (MS)
The goal of this pilot clinical trial is to study is to test the feasibility and effects of a virtual (remote) version of a cognitive rehabilitation intervention - Memory, Attention, and Problem Solving Skills for Persons with MS…
- Trial name
- NCT06709768
- Testing
- Virtual Memory, Attention, and Problem Solving Skills for Persons with MS (MAPSS-MS)
- Volunteers
- 34 people
- Sponsor
- University of Texas at Austin
Fear Anxiety, PTSD
Neuroimaging Memories of Fear and Safety in the Human Brain
The purpose of this research is to use functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral and negative stimuli.
- Trial name
- NCT04975009
- Testing
- Fear conditioning
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Cognitive Function, Memory
A Clinical Trial to Investigate the Efficacy of the Brain Blossom Supplement to Improve Cognitive Function and Memory
This study evaluates the efficacy of BioNatureHealth's Brain Blossom supplement in improving cognitive function and memory in adults aged 50-70 years.
- Conditions
- Cognitive Function, Memory, Cognitive Decline
- Trial name
- NCT07564804
- Testing
- Dietary Supplement: Brain Blossom
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bio Nature Health
Posttraumatic Stress Disorder, Intrusive Traumatic Memories
Tackling Intrusive Traumatic Memories After Childbirth
This single-blind waitlist randomized controlled trial aims to investigate the efficacy of a single-session behavioral intervention composed of a brief evocation of the childbirth memory followed by a visuospatial task (the…
- Trial name
- ASTRAL (NCT05381155)
- Testing
- A single-session behavioral intervention composed of a brief evocation of the childbirth memory followed by a Tetris gameplay
- Where
- 2 sites in Switzerland
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Parkinson Disease
Facilitating Motor Skill Learning in Parkinson's Disease III
The study is designed to assess the effects of cardiovascular (aerobic) exercise on motor skill learning in Parkinson patients. Specifically, the investigators examine whether moderate-intense aerobic exercise, performed…
- Trial name
- FaST-PD-III (NCT04653285)
- Testing
- motor skill practice, aerobic exercise, rest
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Erlangen-Nürnberg
Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic
Reducing Intrusive Memories in Refugees and Asylum Seekers With PTSD: A Pilot Study
This research study was designed to investigate the use of a simple cognitive task for decreasing the number of intrusive memories of traumatic events experienced by refugees and asylum seekers with a diagnosis of Post-traumatic…
- Conditions
- Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Mental Disorder, Trauma and Stressor Related Disorders
- Trial name
- NCT04394832
- Testing
- Brief cognitive intervention
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Surrey
Major Depressive Disorder
The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?
The purpose of this study is to determine whether memantine will enhance the therapeutic of effect on depression and prevent memory and other cognitive problems caused by ECT.
- Trial name
- ECTAug (NCT00988663)
- Testing
- memantine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jerrry L Lewis
Dementia
Perceptions Regarding Investigational Screening for Memory Problems in Primary Care
The purpose of this study is to conduct a cross-sectional survey of primary care patients to better understand their perceptions of the risks and benefits of a screen and subsequent diagnostic confirmation of dementia.
- Trial name
- PRISM-PC (NCT00759252)
- Where
- United States
- Volunteers
- 954 people, healthy volunteers welcome
- Sponsor
- Indiana University