Clinical trials: Memory Disorders
Traumatic Brain Injury, Cognitive Impairment
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Difficulties with intellectual functioning, particularly memory functions, are common and source of long-term disability after Traumatic Brain Injury (TBI).
- Trial name
- RIVET (NCT01670526)
- Testing
- Rivastigmine Transdermal Patch
- Where
- 8 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease and Related Dementia, Fall Injury
Fall Detection and Prevention for Memory Care Through Real-time Artificial Intelligence Applied to Video
The purpose of the research is to study a new safety monitoring system developed by SafelyYou to help care for a loved one with dementia. The goal is to provide better support for unwitnessed falls.
- Trial name
- NCT03685240
- Testing
- SafelyYou Fall Prevention System
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- SafelyYou
Mental Disorders
Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren Syndrome
It's well established in the literature that emotional events are more likely to be remembered than neutral events. Although this Emotional Enhancement of Memory (EEM) has been well demonstrated in the adult literature, little is…
- Trial name
- EEM-TAdev (NCT03688516)
- Testing
- Manipulation of valence and modality, Spatial and recognition memory, Source and content memory
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Epilepsy, Drug Resistant
The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory Epilepsy
The aim of this study is to evaluate the clinical efficacy of everolimus as an adjunctive therapy for refractory epilepsy. The significance lies in addressing whether the mTOR inhibitor sirolimus has antiepileptic adjunctive…
- Trial name
- NCT07095933
- Testing
- Everolimus
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Xuanwu Hospital, Beijing
Spatial Memory Disorder
Sevoflurane General Anesthetic and Spatial Memory in Humans
The goal of this observational study is to learn about the effect of general anesthetic on spatial memory in adults who will undergo to an elective surgery.
- Trial name
- NCT05991817
- Testing
- Surgery/general anesthesia
- Where
- 2 sites in Chile
- Volunteers
- 22 people
- Sponsor
- University of Chile
Major Depressive Disorder, Depressive Symptoms
A Randomised Controlled Clinical Trial of Memory Specificity Training (MEST) for Depression
Depression involves the tendency to recall overgeneral personal memories, a phenomenon which has been linked to numerous adverse psychological outcomes.
- Trial name
- MEST (NCT01882452)
- Testing
- Memory Specificity Training, Education and Support
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Medical Research Council
Schizophrenia
A Study to Evaluate the Effects of Once Daily Doses of AQW051 on Cognition, in Stable Schizophrenia Patients
This is a study in chronic stable Schizophrenia with the purpose to answer the question of whether agonism of the nicotinic alpha7 receptor is capable of enhancing cognition in a well defined chronic stable patient population…
- Trial name
- NCT01730768
- Testing
- AQW051
- Where
- 13 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novartis Pharmaceuticals
Brain Diseases, Epilepsy
Amygdala Memory Enhancement
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories.
- Conditions
- Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury
- Trial name
- NCT05065450
- Testing
- Intracranial Stimulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
Alzheimer Disease
Memory for Music: Individual Intensive Musical Training in Alzheimer's Disease
This project, called Memory for Music, focuses on the increasing number of people worldwide living with dementia, especially Alzheimer's disease (AD).
- Trial name
- M4M (NCT06611878)
- Testing
- Music training - intensive, Music training - minimal, Treatment as Usual (TAU)
- Where
- 6 sites in Argentina, Austria and 1 more
- Volunteers
- 113 people
- Sponsor
- NORCE Norwegian Research Centre AS
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Neurocognition
Translational Research Evaluating Neurocognitive Memory Processes
The purpose of this study is to evaluate the psychometric properties and utility of new, computerized, neurocognitive measures in humans with depression, and humans with depression undergoing electroconvulsive therapy (ECT).
- Trial name
- TREC-MP (NCT01834677)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Duke University
Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders
Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators
Police officers, correctional service officers, and 911-operators are at increased risk for suffering from trauma-related disorders due to their direct and indirect exposure to life-threatening events, such as shootings, violent…
- Conditions
- Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders, Adjustment Disorders, Acute Stress Disorder
- Trial name
- NCT03152175
- Testing
- Propranolol Hydrochloride
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Douglas Mental Health University Institute
Glomerulonephritis Acute
Urinary T Cell Biomarker for Prediction in ANCA Glomerulonephritis
Urinary T lymphocytes may be predictive for clinical outcome in patients with ANCA associated glomerulonephritis (ANCA GN). The investigators hypothesize that the amount of CD4+ effector/memory T cells in urine at time of…
- Trial name
- NCT04320667
- Testing
- Flow cytometry analysis of urine samples
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 79 people
- Sponsor
- Charite University, Berlin, Germany
Cerebrovascular Disorders, Memory
Roflumilast to Treat Cognitive Sequela After Stroke
The aim of the current project is to validate the effects of chronic rolflumilast treatment (12 weeks) on cognitive functions (i.e.
- Conditions
- Cerebrovascular Disorders, Memory, Functional Recovery, Drug Intervention
- Trial name
- ROSTMEMA (NCT04854811)
- Testing
- Roflumilast Oral Tablet
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Brain Tumor
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
The objective of this study is to estimate the feasibility and acceptability of cognitive training in the virtual reality setting with children undergoing radiotherapy for brain tumors.
- Trial name
- NCT05947045
- Testing
- Cognitive training via iPad, Cognitive training via virtual reality
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- St. Jude Children's Research Hospital
HIV Infections, HIV Seronegativity
A Study of the Effectiveness of an HIV Vaccine (ALVAC vCP205) to Boost Immune Functions in HIV-Negative Volunteers Who Have Already Received an HIV Vaccine
The purpose of this study is to see if it is safe to give an HIV vaccine (vCP205) to volunteers who received an HIV vaccine at least 2 years ago, and to study how the immune system responds to this vaccine.
- Trial name
- NCT00001136
- Testing
- ALVAC-HIV MN120TMG (vCP205)
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dementia
The Effect of the Glycemic Load of Meals on the Cognition and Mood of Older Adults
A lower rather than a higher glycemic load (GL) meal has been shown to benefit cognition and mood, however, the data in older adults and those most prone to cognitive dysfunction, is limited and conflicting.
- Trial name
- NCT01842022
- Testing
- Isomaltulose, Sucrose, Glucose
- Where
- United Kingdom
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Swansea University
Alzheimer Disease, Semantic Dementia
Memory and Social Interactions
Memory and social interaction are intimately linked. On the one hand, social interaction is a privileged context for learning, and on the other hand, appropriate social interactions involve remembering the partners encountered…
- Trial name
- MEM&SO (NCT05800028)
- Testing
- Learning new information
- Where
- France
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Pain, Retention Disorders, Cognitive
Legacy Intervention Family Enactment (LIFE)
The research activities funded through PAR "Dissemination and Implementation Research in Health" in grant R21NR011112 "Legacy Intervention Family Enactment (LIFE)" have been varied and highly successful.
- Conditions
- Pain, Retention Disorders, Cognitive, Other Chronic Illness, Palliative Care
- Trial name
- LIFE (NCT02007564)
- Testing
- LIFE Intervention
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Alabama, Tuscaloosa