Clinical trials: Memory Deficits
Mild Cognitive Impairment
Water-based Activity to Enhance Recall in Veterans
This two-year study will evaluate the feasibility of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI).
- Trial name
- WATER-VET (NCT02614092)
- Testing
- Water-based Activity + Cognitive Training
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer Disease, Mild Memory Disturbance
The MObile AssessMENT of Behavioral and Psychological Symptoms of Dementia in Amnestic MCI and AD (MOMENT) Study
The purpose of this research study is to learn whether it is possible and useful for caregivers to report behavioral or psychological symptoms of people with mild memory problems or Alzheimer's disease through a smartphone mobile…
- Conditions
- Alzheimer Disease, Mild Memory Disturbance, Mild Cognitive Impairment
- Trial name
- MOMENT (NCT04482036)
- Testing
- Mobile Phone Application Assessments, Standard Assessments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Indiana University
Memory Impairment Due to Corticosteroid Use, Hypomania Due to Corticosteroid Use
Clinical Trial of Lamotrigine to Reverse Cognitive Impairment in Chronic Corticosteroid-Treated Patients
The purpose of this study is to determine if lamotrigine therapy is associated with improvement in mood, memory and hippocampal size and function in patients receiving chronic corticosteroid therapy.
- Conditions
- Memory Impairment Due to Corticosteroid Use, Hypomania Due to Corticosteroid Use, Hippocampal Atrophy Due to Corticosteroid
- Trial name
- NCT00223262
- Testing
- Lamotrigine (Drug)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Texas Southwestern Medical Center
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)
An urgent need exists to find effective treatments for Alzheimer's disease (AD) that can arrest or reverse the disease at its earliest stages.
- Trial name
- NCT01767909
- Testing
- Insulin (Humulin® R U-100)
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Southern California
Memory Disorders, Multiple Sclerosis
Recall Enhancement Through Treatment With Atomoxetine in MS (RETAIN-MS)
The purpose of this crossover trial is to investigate whether atomoxetine (versus placebo) improves memory function in persons with memory deficits due to multiple sclerosis.
- Trial name
- NCT03091400
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cannabis Intoxication
The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking
This study was authorized by the California Legislature (Assembly Bill 266, the Medical Marijuana Regulation and Safety Act to help with detection of driving under the influence of cannabis.
- Trial name
- NCT02849587
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Mild Cognitive Impairment, Dementia
A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment
The purpose of this study is to determine whether treatment with the investigational drug ladostigil will delay the onset of Alzheimer's disease(AD) in patients with Mild Cognitive Impairment (MCI).
- Trial name
- NCT01429623
- Testing
- ladostigil hemitartrate
- Where
- 12 sites in Austria, Germany and 1 more
- Volunteers
- 210 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Delirium, Postoperative Cognitive Dysfunction
Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial
The purpose of this study is to determine whether preoperative administration of Rivastigmine prevents the incidence of postoperative delirium in patients undergoing major surgery as well as postoperative cognitive dysfunction.
- Trial name
- NCT00835159
- Testing
- Rivastigmine Patch
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Memory Impairment
Better Memory With Literacy Acquisition Later in Life
This study aims to discover whether acquiring basic-literacy in adulthood can improve episodic memory and brain structural and functional connectivity.
- Trial name
- NCT04473235
- Testing
- Literacy training, Non-Literacy training
- Where
- Brazil
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Organic Memory Impairment
Attenuation of Corticosteroid Induced Hippocampal Changes
The purpose of the study is to determine if an investigational drug called memantine,used here as add-on therapy, is associated with improvements in memory, mood and asthma symptoms.
- Trial name
- NCT01656187
- Testing
- Memantine 10 mg capsule
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Texas Southwestern Medical Center
Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder
Network Control TMS fMRI
This study uses different types of functional magnetic resonance imagining (fMRI) to generate individual transcranial magnetic stimulation (TMS) targets.
- Conditions
- Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, Working Memory
- Trial name
- NCT05736458
- Testing
- Transcranial Magnetic Stimulation (TMS), High controllability TMS target
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Urge Incontinence, Urinary Incontinence, Urge
Treatment of Incontinence Without Memory Problems
An 8-week randomized, controlled, pilot clinical trial of Mirabegron compared to a standard anticholinergic therapy (Detrol LA) in elderly women with urgency urinary incontinence.
- Trial name
- TRIUMPH (NCT02436889)
- Testing
- Mirabegron, Tolterodine Tartrate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Memory Impairment
The Efficacy of Phosphatidylserine-Omega3 in Elderly Subjects With Memory Impairment
The primary objective of this trial is to assess the ability of Phosphatidylserine-Omega3 to improve cognitive performance in elderly subjects with memory impairment.
- Trial name
- NCT00736034
- Testing
- Phosphatidylserine-Omega3 (SharpPS™-Gold)
- Where
- Israel
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Enzymotec
Attention Deficit Disorder
Neurofeedback and Working Memory Training for Children and Adolescents With ADHD
The purpose of this study is to investigate if neurofeedback and working memory training improves core symptoms of ADHD in children and adolescents.
- Trial name
- KITE (NCT01841151)
- Testing
- SCP training, Live Z-score training, WM training
- Where
- Sweden
- Volunteers
- 202 people
- Sponsor
- Karolinska Institutet
Mild Cognitive Impairment, Alzheimer's Disease
Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training
The purpose of this pilot study will be to test whether Kundalini yoga (KY) and Kirtan Kriya (KK) yogic meditation is superior to Memory Enhancement Training (MET) for improving cognitive functioning, health (including…
- Trial name
- NCT03503669
- Testing
- Memory Training, Kundalini yoga and meditation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Sickle Cell Disease
A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot Study
The overall goal of this project is to determine the feasibility of conducting a cognitive intervention for children with sickle cell disease.
- Trial name
- NCT00895154
- Testing
- General Tutoring, Memory Training
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Alzheimer Disease
tACS for Amyloid-β Reduction in Alzheimer's Disease
Alzheimer's Disease (AD) is characterized by amyloid-β (Aβ) plaque buildup and phosphorylated tau (p-tau) in the brain, as well as widespread neurodegeneration.
- Trial name
- NCT03290326
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment, Memory Disorders
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment
The purpose of this study is to evaluate if systematic cognitive training can improve cognitive performance in participants (55 and older) with memory loss.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Memory Impairment, Cognitive Impairment
- Trial name
- CogTraining (NCT03205709)
- Testing
- Computerized Cognitive Training, Crossword Puzzles
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- New York State Psychiatric Institute
Age-Related Memory Disorders
Study of LX6171 in Elderly Volunteers With Age Associated Memory Impairment
The purpose of the study is to determine the safety, tolerability, and effectiveness of 2 dose levels of LX6171 given over 28 days in patients with Age Associated Memory Impairment (AAMI).
- Trial name
- NCT00691808
- Testing
- LX6171 High Dose, LX6171 Low Dose
- Where
- 2 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Lexicon Pharmaceuticals