Clinical trials: Memory Decline
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Memory Disorders in Old Age
Improving Working Memory in Older Adults
The research program will evaluate the theoretical claim that age-related memory and cognitive decline in humans result from the inefficient orchestration of rhythmic activity within large-scale cortical networks.
- Trial name
- NCT04362696
- Testing
- High definition transcranial electrical current stimulation
- Where
- United States
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Aging, Pain, Acute
Effects of Acute Pain on Motor Learning in Young vs Older Adults
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its…
- Conditions
- Aging, Pain, Acute, Cognitive Decline, Motor Activity
- Trial name
- NCT05471557
- Testing
- pain delivery
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Aging, MCI
Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation
The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of…
- Trial name
- NCT06633952
- Testing
- MediTrain, Worder, noninvasive neurostimulation device
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cognitive Decline, Cognitive Function
A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
This study will evaluate the efficacy of 1MD Nutrition's MindMD supplement in improving and maintaining cognitive function and memory.
- Trial name
- NCT06523218
- Testing
- MindMD Supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Scale Media Inc
Lifestyle Risk Reduction
EMuNI Project: Multiple Nonpharmacological Interventions
By 2030, the global prevalence of Alzheimer's Disease (AD) is predicted to reach 65.7 million worldwide. Despite extensive research efforts, a cure for AD has not been identified.
- Trial name
- EMuNI (NCT03382353)
- Testing
- Nutritional supplementation, Educational training, Counselling on a brain-healthy diet
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Aging, Memory Impairment
Neurocognitive Study for the Aging-a Longitudinal Study With a Greek Cypriot Cohort
The Neurocognitive Study for the Aging (NEUROAGE) was initially funded by the Cyprus Innovation Foundation and has received subsequent funding by the European Union Regional Development Fund.
- Conditions
- Aging, Memory Impairment, Cognitive Decline, Mild Cognitive Disorder
- Trial name
- NEUROAGE (NCT01481246)
- Testing
- Categorization training, Psychosocial and Psychoeducational Group training
- Where
- Cyprus
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Older Adults (50-90 Years)
Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects.
- Trial name
- NCT01840839
- Testing
- brain stimulation
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Chronic Kidney Diseases, Dementia
BRINK (BRain In Kidney Disease) Memory Study 2.0
In this study, the investigators will be looking at results of tests of memory and thinking and daily activities in a group of people without known chronic kidney disease (CKD) , and a group of CKD patients, and follow the…
- Conditions
- Chronic Kidney Diseases, Dementia, Dementia, Vascular, Stroke
- Trial name
- BRINK (NCT04975464)
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Anne Murray
Cognitive Function, Memory
A Clinical Trial to Investigate the Efficacy of the Brain Blossom Supplement to Improve Cognitive Function and Memory
This study evaluates the efficacy of BioNatureHealth's Brain Blossom supplement in improving cognitive function and memory in adults aged 50-70 years.
- Conditions
- Cognitive Function, Memory, Cognitive Decline
- Trial name
- NCT07564804
- Testing
- Dietary Supplement: Brain Blossom
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bio Nature Health
Alzheimer Disease, Dementia
Movement Intervention for Memory Enhancement
Dancing is a complex sensorimotor rhythmic activity that integrates cognitive, physical, and social components and is applicable to seniors with various fitness levels.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Decline, Cognitive Impairment
- Trial name
- MIME (NCT03475316)
- Testing
- Social Dancing, Treadmill Walking
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Aging, Cognitive Decline
Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition
Extended bouts of periodic mastication and intermittent energy restriction (IER) may improve cognitive performance in the context of adult hippocampal neurogenesis in an ageing population.
- Trial name
- ChANgE (NCT03457870)
- Testing
- Intermittent Energy Restriction, Chewing, Chewing + Intermittent Energy Restriction
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- King's College London
Mild Cognitive Impairment, Mild Dementia
Assessing Cognitive Decline at Home
Neuropsychiatric symptoms (NPS) refer to a range of mental and emotional issues that can be observed through how patients move, perform daily tasks, and express feelings on their faces.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Dementia Alzheimers, Dementia
- Trial name
- NCT06704971
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stanford University
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Aging, Alzheimer Disease
Heart Rate and Breathing Effects on Attention and Memory
In the current study, we will examine how daily paced breathing affects plasma amyloid beta levels and the rate of learning in older adults.
- Conditions
- Aging, Alzheimer Disease, Age-related Cognitive Decline
- Trial name
- HeartBEAM (NCT05602220)
- Testing
- Brain training, Paced breathing
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alzheimer Disease, Dementia
Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease
This is a 24-month, monocentric, exploratory and observational clinical study aimed at developing and validating a blood-based diagnostic test for Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Disorders, Cognitive Decline
- Trial name
- ADKIT (NCT07294586)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Age-related Memory Disorders, Mood Disorders
Omega-3 and Blueberry Supplementation in Age-Related Cognitive Decline
The aim of this study is to determine the efficacy of 6 months' dietary supplementation with omega-3 fatty acids and whole freeze dried blueberry powder in improving cognition in older adults.
- Trial name
- NCT01746303
- Testing
- Omega-3 fatty acid, Blueberry powder
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Age-Related Memory Disorders
A Safety and Efficacy Study of Ispronicline (TC-1734-112) in Subjects With Age Associated Memory Impairment (AAMI)
The purpose of this Phase II study is to evaluate the efficacy and safety of ispronicline (TC-1734-112) compared to placebo (inactive substance pill) in patients with age associated memory impairment (AAMI).
- Trial name
- NCT00109564
- Testing
- ispronicline (nicotinic acetylcholine receptor agonist)
- Where
- 15 sites in United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Cognitive Decline
The Impact of Exercise on Hippocampus-dependent Cognition and the Gut Microbiota
The NeuroFit study will be investigating the impact of exercise on global cognition, hippocampus-dependent memory function and the gut microbiota in a middle-aged population.
- Trial name
- NeuroFit (NCT05397990)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- King's College London
Parkinson's Disease, Parkinsonism
VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism
VISMEMO-PD is an observational pilot study aimed at investigating visuospatial memory in reaching space and topographical memory in navigational space in patients with Parkinson's disease and Parkinsonism.
- Conditions
- Parkinson's Disease, Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- VISMEMO-PD (NCT07827963)
- Testing
- Multimodal visuospatial and topographical memory assessment
- Where
- 3 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma