Clinical trials: Melatonin
Schizophrenia
Melatonin for Prevention of Metabolic Side Effects of Olanzapine
The purpose of this study is to determine whether melatonin can prevent metabolic side effects of olanzapine such as weight gain, elevated glucose concentrations and lipid abnormalities.
- Trial name
- NCT01593774
- Testing
- Melatonin
- Where
- Iran
- Volunteers
- 36 people
- Sponsor
- Guilan University of Medical Sciences
Obstructive Sleep Apnea
The Effect of Melatonin on Sleep and Ventilatory Control in Obstructive Sleep Apnea
Our hypothesis is that oxidative stress induced during repeated apneas in obstructive sleep apnea (OSA) patients alters the neural control of breathing which destabilizes ventilatory control and exacerbates OSA.
- Trial name
- NCT02484300
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Perimenopausal Disorder
Melatonin Use in Patients With Climacterious Symptoms in the Perimenopause
Menopause is defined as the absence of menstruation for 12 months without a pathological cause and it is marked by physical fluctuations and biological changes that can impact women's quality of life.
- Trial name
- NCT06192641
- Testing
- Melatonin 3 MG
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Univates
Epilepsy
Pilot Study of Melatonin and Epilepsy
The prevalence of epilepsy is 1% in the USA. About 30% of epilepsy patients eventually become refractory to medical treatment. Co morbid conditions are becoming as important as seizure control as these affect overall wellbeing.
- Trial name
- NCT00965575
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Preterm Contractions
Uterine Contractions Under Blue Light
The objective in the current study is to test the hypothesis that nocturnal uterine contractions in preterm women can be suppressed by brief ocular exposure to blue light.The Olcese lab at Florida State University identified a…
- Trial name
- NCT03691740
- Testing
- Ocular light
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Delirium, Melatonin
Melatonin Use in the Intensive Care Elderly Population
The investigators are studying the use of Melatonin in non-ventilated patients over the age of 65. Primary endpoint will be assesments of delirium, with secondary endpoints to include length of stay, use of anti-psychotic…
- Trial name
- MICE (NCT03013790)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- MICE Trial Group
Sleep Disorders, Autism Spectrum Disorder
Verification of the Efficacy of NPC-15 for Sleep Disorders of Children With Autism Spectrum Disorders
The purpose of this study is to verify the efficacy of NPC-15 (melatonin 1 mg/d or 4 mg/d) versus placebo to sleep latency with electronic sleep diaries.
- Trial name
- NPC-15-5 (NCT02757066)
- Testing
- NPC-15 Granules Lower Dose, NPC-15 Granules Higher Dose
- Volunteers
- 196 people
- Sponsor
- Nobelpharma
Post Operative Delerium
The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries
The aim of this study is to illuminate the effect of combination of dexmedetomidine and oral melatonin versus the use of dexmedetomidine infusion alone on the improving of post-operative delirium (POD) on patients undergoing open…
- Trial name
- NCT07475156
- Testing
- Dexmedetomidine (DEX), Melatonin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Insomnia, Insomnia Disorder
A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia
The purpose of this study is to assess the relative effectiveness, safety, and durability of the most commonly used prescription (zolpidem, trazodone) and over-the-counter (OTC) (melatonin, diphenhydramine) medications for…
- Conditions
- Insomnia, Insomnia Disorder, Chronic Insomnia, Chronic Insomnia Disorder
- Trial name
- NCT07542756
- Testing
- Sleep Hygiene Education, Melatonin IR, 3 mg, Melatonin IR, 5 mg
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pennsylvania
Immediate Dental Implant
Evaluation of Melatonin Application of Immediate Dental Implant
The presence of periapical pathology, the absence of kera¬tinized tissue and lack of complete soft tissue closure over the extraction socket have been reported a drawbacks of immediate implant placement .
- Trial name
- NCT03689998
- Testing
- immediate implant placement, Melatonin
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
A Study to Investigate the Pharmacokinetics of Prolonged-release Melatonin Compared to Standard, Immediate-release Melatonin in Healthy Adults
A study comparing the pharmacokinetics of prolonged-release melatonin versus standard, immediate-release melatonin. Multiple blood draws over a 10-hour period will be analysed to determine the area under the curve, time to peak…
- Trial name
- NCT04067791
- Testing
- Prolonged-Release Melatonin, Immediate-Release Melatonin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Sleep Onset Latency
Circadian Light Exposure Adjustment for Restfulness
Many young children are exposed to light int he evening hours before bedtime. Children's biological clocks are highly sensitive to evening light exposure, which can delay the timing of the clock and make it harder to fall asleep.
- Trial name
- CLEAR (NCT07391852)
- Testing
- Amber Tinted Glasses, Clear Glasses, Smart Lightbulbs
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Arizona
Postoperative Pain
The Role of Preoperative Melatonin in Reducing the Inhaled Isoflurane Requirements in Open Nephrectomy
Melatonin is a hormone that the pineal gland in the brain produces. Melatonin fulfills many functions in the body but it is mostly known for maintaining a circadian rhythm that is governed by the central circadian pacemaker…
- Trial name
- NCT04959825
- Testing
- Melatonin 5 mg, Sugar Coated Tablets
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Insomnia
Efficacy and Safety of Circadin® 2 mg in the Treatment of Primary Insomnia Patients
This is a randomised, placebo controlled study to evaluate the efficacy of a 3 week treatment period with Circadin® 2 mg in shortening sleep latency in patients with primary insomnia aged 18-80 with melatonin deficiency.
- Trial name
- NCT00397189
- Testing
- Circadin
- Where
- United Kingdom
- Volunteers
- 930 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Sleep Disturbance
Comparison Between the Effect of Two Different Doses of Oral Melatonin on Sleep Quality After Total Hip Arthroplasty
Considering the fact that melatonin was safely and effectively used in higher doses in multiple surgical conditions , the present study hypothesized that increasing melatonin dose in THA would have better benefits for patients.
- Trial name
- NCT07732725
- Testing
- Melatonin 5 MG, Melatonin 10 MG
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Benha University
Bipolar Disorder, Circadian Rhythm
Effects of Sex Hormones on Circadian Rhythm in Men and Women
For many years researchers have been trying to better understand the regulation of sleep and activity by studying circadian (daily) rhythms of human beings.
- Conditions
- Bipolar Disorder, Circadian Rhythm, Depressive Disorder
- Trial name
- NCT00001285
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Hemodialysis Complication, Oxidative Stress
Effect of Melatonin in Pediatric Hemodialysis Patients
A Prospective, randomized, double-blinded, placebo-controlled trial will be conducted at the pediatric dialysis unit, Children's Hospital, Ain Shams University in order to investigate the benefits of melatonin supplementation on…
- Conditions
- Hemodialysis Complication, Oxidative Stress, Inflammation
- Trial name
- NCT05570526
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Sleep Disturbance, Trauma
Treatment for Sleep Disturbance in Orthopaedic Trauma Patients
The purpose of the study is to test the efficacy of sleep treatment in human patients following traumatic injury. Specifically, the study will determine if treatment consisting of melatonin and education related to sleep habits…
- Trial name
- NCT03779243
- Testing
- Melatonin 5mg and Sleep Education
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Acute Myocardial Infarction
The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty
Background: Experimental studies have documented the beneficial effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage and limiting cardiac pathophysiology in models of experimental…
- Trial name
- MARIA (NCT00640094)
- Testing
- melatonin
- Where
- 3 sites in Spain
- Volunteers
- 272 people
- Sponsor
- Alberto Domínguez Rodríguez
Premedication, Anaesthesia
Melatonin Premedication in Children Undergoing Surgery
Melatonin has been proposed as alternative to midazolam as a premedication in procedures preceding anaesthesia induction. The objective of this prospective, randomized, double-blind study is to investigate the possible effect of…
- Trial name
- NCT02265822
- Testing
- melatonin in children premedication, midazolam in children premedication
- Volunteers
- 92 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"