Clinical trials: Melatonin
Dental Implants, Immediate Implant Placement
Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration
This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar…
- Conditions
- Dental Implants, Immediate Implant Placement, Osseointegration
- Trial name
- NCT07610876
- Testing
- Autologous Demineralized Dentin Graft, Melatonin gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Impacted Third Molar Tooth
The Effect of Melatonin Application Following Removal of Impacted Third Molar
In the present study, the main hypothesis hypothesizes that the local application of melatonin in the post-extraction socket produces favorable differences in the immediate postoperative period, as anti-inflammatory, analgesic…
- Trial name
- NCT04424875
- Testing
- 3 mg melatonin
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Fayoum University
Sleep
A Single-Group Study to Examine the Efficacy of a Melatonin Lotion With Magnesium to Improve Sleep Quality and Quantity
This study will evaluate the efficacy of Asutra's 'Dream the night away' nighttime lotion with melatonin and magnesium on sleep health in terms of quantity, quality, ease of falling asleep or falling back asleep after waking in…
- Trial name
- NCT06146712
- Testing
- Asutra's 'Dream the night away' nighttime lotion
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Asutra
Dental Implant, Immediate Dental Implant Placement
Melatonin Effect on Immediate Dental Implants in the Posterior Mandible
This pilot randomized controlled clinical trial aims to evaluate the feasibility, clinical safety, and preliminary radiographic osteogenic effects of applying topical 1% w/w melatonin gel during immediate implant placement in the…
- Conditions
- Dental Implant, Immediate Dental Implant Placement, Alveolar Bone Loss, Bone Density
- Trial name
- NCT07869030
- Testing
- 1% w/w Melatonin Gel, Standard Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Future University in Egypt
REM Sleep Behavior Disorder, Parkinson Disease
Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease
The purpose of this study is to determine whether melatonin prolonged-release (PR) and clonazepam are effective and safe in the treatment of rapid eye movement behavior disorder (RBD) of patients with Parkinson's disease (PD).
- Trial name
- NCT02789592
- Testing
- Melatonin PR, Clonazepam
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Cancer, Fatigue
Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer
BACKGROUND: Patients with advanced cancer often suffer from fatigue and other symptoms and problems such as insomnia, appetite loss and pain. Problems that may have great consequences for their quality of life.
- Trial name
- NCT00925899
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Bispebjerg Hospital
Depressive Disorder, Major
Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder
The main objective was to compare the differences of PSG parameters and plasma melatonin levels before and after treatment with escitalopram for 8 weeks.
- Trial name
- NCT04013464
- Testing
- Escitalopram
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Postural Instability
Investigation of Melatonin and Zolpidem Effect on Postural Instability in Healthy Adult Subjects
This is a randomised, double-blind, 3-way crossover, single dose, placebo-controlled study investigating the effect on night time awakening body sway of melatonin and zolpidem in healthy adult subjects aged of 55 to 64 years.
- Trial name
- NCT01280734
- Testing
- Circadin (R) 2 mg, Stilnox (R) 10 mg
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Neurim Pharmaceuticals Ltd.
Huntington Disease
Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study
The purpose of the study is to evaluate the efficacy of exogenous melatonin in improving sleep quality in HD gene carriers.
- Trial name
- NCT04421339
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Electroencephalography, Melatonin
Sedation and Nursing Management in EEG Recording in Children
Electroencephalogram (EEG) has an important place in establishing the correct diagnosis, providing appropriate intervention, and predicting the prognosis in the long term in children.
- Conditions
- Electroencephalography, Melatonin, Chloral Hydrate, Hydroxyzine
- Trial name
- NCT05492812
- Testing
- Sedation and Nursing Management in EEG Recording in Children, Chloral Hydrate, Hydroxyzine
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Atopic Dermatitis
Treatment of Nighttime Pruritus in Atopic Dermatitis
This study will look at melatonin vs. first generation antihistamine vs. placebo in improving nighttime itching in children with atopic dermatitis.
- Trial name
- NCT03688464
- Testing
- Melatonin, Diphenhydramine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Oral, Melatonin
Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery
This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.
- Conditions
- Oral, Melatonin, Pregabalin, Postoperative Pain
- Trial name
- NCT07344467
- Testing
- Melatonin capsule, Pregabalin capsule
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Alzheimer Disease, Agitation,Psychomotor
Clinical Trial on Agitation in Alzheimer's Dementia
The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based (Delta-9-Tetrahydrocannabinol) formulation administered twice a day on Agitation in patients with mild to severe dementia from…
- Conditions
- Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
- Trial name
- CALMA (NCT05543681)
- Testing
- IGC-AD1-Active
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 164 people
- Sponsor
- IGC Pharma, LLC
Second Generation Antipsychotic Induced Metabolic Adverse Effects
Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics
Schizophrenia and bipolar disorder are frequently associated with an elevated risk for obesity, metabolic syndrome, diabetes mellitus, dyslipidemia and other metabolic disturbances.
- Trial name
- NCT01811160
- Testing
- Melatonin
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Schizophrenia, Schizoaffective Disorder
Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia
In this trial, researchers aim to investigate if prolonged-release melatonin can facilitate the withdrawal of chronic benzodiazepine administration in patients with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Affective Disorder
- Trial name
- SMART (NCT01431092)
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 86 people
- Sponsor
- Lone Baandrup
Insomnia
Relationship of Nocturnal Concentrations of Melatonin, γ-aminobutyric Acid and Total Antioxidants With Insomnia
To analyze the relationship of nocturnal concentrations of melatonin, γ-aminobutyric acid and total antioxidants with insomnia after stroke.
- Trial name
- NCT03202121
- Testing
- insomnia group, non-insomnia group, normal control
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- China Rehabilitation Research Center
Healthy, Circadian Rhythm
Effects of Different Colors of Light on Human Physiology
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system (alertness, performance, microsleeps, brain activity)…
- Trial name
- NCT00200863
- Testing
- Monochromatic visible light exposure
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Parkinson's Disease, Nocturia
Melatonin for Nocturia in Parkinson's Disease
This is an an open label clinical trial of sustained-release Melatonin 2mg once daily for 12 weeks in patients with Parkinsons's Disease reporting nocturia, defined as getting up regularly at night > twice to pass urine.
- Trial name
- NCT02359448
- Testing
- Melatonin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Pineal Tumor
Melatonin Replacement Therapy in Pinealectomized Patients
This is an open-label, single-arm, single-center, proof-of-concept study to assess the effects of melatonin on cardiac autonomic activity in melatonin non-proficient pinealectomized patients.
- Trial name
- NCT03885258
- Testing
- Melatonin Replacement Therapy
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- University of Sao Paulo