Clinical trials: Melasma
Melasma
Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid
Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma.
- Trial name
- NCT00166192
- Testing
- Jessner's solution chemical peel, Trichloroacetic acid chemical peel
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Emory University
Melasma
Spironolactone for the Treatment of Melasma
The purpose of this study is to prospectively gather data on the efficacy and tolerability of spironolactone to treat refractory melasma and to compare treatment response of randomized 50 mg, 100mg, and 200mg per day dosing.
- Trial name
- NCT03953209
- Testing
- Spironolactone 50Mg Tablet, Spironolactone 100Mg Tablet, Spironolactone 200Mg
- Where
- United States
- Sponsor
- Medical University of South Carolina
Melasma
Efficacy of Intralesional PRP +/- Topical Silymarin in the Treatment of Melasma
Melasma is an acquired disorder of melanogenesis leading to hyperpigmentation and manifested by symmetrical brown to gray-black macules and patches with serrated irregular edges .
- Trial name
- NCT05626881
- Testing
- PRP, sylimarin cream
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Post-inflammatory Hyperpigmentation, Melasma
A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants
The study aims to evaluate the efficacy of a facial sunscreen under two experimental conditions-untinted and tinted-in improving facial spots (melasma and solar lentigines/post-inflammatory hyperpigmentation) after 8 weeks of…
- Conditions
- Post-inflammatory Hyperpigmentation, Melasma, Solar Lentigo
- Trial name
- El Porto Ex-US (NCT07679945)
- Testing
- Sunscreen untinted, Sunscreen tinted
- Where
- Brazil
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06268496
- Testing
- serum formula 2039125 03
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Trichloroacetic Acid (TCA) Combined With Microdermabrasion in Treatment of Melasma
1. To detect the efficacy and safety of combined TCA and MDA in treating melasma. 2. To compare the efficacy and safety of using different TCA concentrations (15% \& 20%) alone and in combination with MDA in treatment of melasma.
- Trial name
- NCT04823520
- Testing
- TCA
- Volunteers
- 60 people
- Sponsor
- Assiut University
Melasma
Anti-pigmenting Effect of a Routine of Facial Products in Subjects With Melasma
This 6 month, comparative study assesses the benefit of a dermocosmetic regimen (Serum B3 + B3 retinol night cream) for 6 months compared to hydroquinone 4% (the gold standard in hyperpigmentation) followed by the dermocosmetic…
- Trial name
- NCT06516224
- Testing
- Liftactiv® B3 Serum, Liftactiv® B3 retinol night cream, Sunscreen UVAage® Inter SPF 50+
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Treatment of Melasma With Yellow Light Compared to Tranexamic Acid
Photobiomodulation (PBM) has been suggested as an alternative treatment for Melasma, showed by the in vitro data, inhibition of the tyrosinase enzyme and reduction in the pigment content by autophagy.
- Trial name
- NCT05326997
- Testing
- Photobiomodulation group, Group control (Tranexamic acid)
- Where
- 2 sites in Brazil
- Volunteers
- 21 people
- Sponsor
- University of Nove de Julho
Melasma
Curcuma Xanthorriza Roxb. 10% Cream for Melasma
Melasma is an acquired hyperpigmentation disorder with a multifactorial etiology and complex pathogenesis that can significantly diminish the quality of life for affected patients.
- Trial name
- NCT06153134
- Testing
- 10% Curcuma xanthorriza Roxb., 2% Kojic Acid
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Melasma
Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma
A randomized clinical trial will be done on 92 patients , randomly divided into two groups by lottery method to compare the efficacy and safety of topical silymarin cream 0.7% with topical 4% hydroquinone cream.
- Trial name
- NCT03982849
- Testing
- Hydroquinone 4% Cream, silymarin 0.7% cream
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Islamabad Medical and Dental College
Vitiligo, Melasma
In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy
This is a pilot study to evaluate the findings of the Reflectance Confocal Microscopy when performed in cutaneous pigmentary disorders, such as vitiligo, melasma, post-inflammatory hyper-pigmentation and hypo-pigmentation.
- Conditions
- Vitiligo, Melasma, Hyperpigmentation, Hypopigmentation
- Trial name
- NCT00771355
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Melasma
Oral Superoxide Dismutase (GLISODin) to Decrease Melasma Severity.
Oxidative stress has been reported to play a role in melasma pathophysiology. The objective of the study is to compare oral superoxide dismutase (GLISODin) to placebo, in combination to sunscreen to decrease melasma severity.
- Trial name
- Glisodin (NCT03878433)
- Testing
- Glisodin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Hyperpigmentation, Melasma (Facial Melasma)
Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation
This is a single-center, single-blind clinical study designed to evaluate the efficacy of a depigmenting gel cream through clinical, subjective, and instrumental assessments.
- Trial name
- HYPERPIG (NCT07769268)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Melasma
Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma
Melasma is a chronic acquired disorder of facial hyperpigmentation that significantly affects quality of life. Both intralesional tranexamic acid and mandelic acid chemical peels are effective treatment options with favorable…
- Trial name
- NCT07604844
- Testing
- Mandelic Acid Peel, Intralesional Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Combined Military Hospital Abbottabad
Hyperpigmentation, Melasma
A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation
This a short four-week pilot study to measure the efficacy and tolerance of two brightening serums (cosmetics) versus 4% hydroquinone. The study was conducted in two sites across the USA, one in PA and in one in CA.
- Conditions
- Hyperpigmentation, Melasma, Dark Spots
- Trial name
- NCT07644871
- Testing
- Facial Cleanser, Facial Moisturizer, Sunscreen SPF 55
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Refractory Melasma
Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid
Melasma is a common acquired disorder of hyperpigmentaion caused by increased melanin production by melanocytes. Melasma is a name derived from the Greek word melas meaning black.It is characterized by the appearance of brownish…
- Trial name
- NCT06522984
- Testing
- Tranexamic acid injection
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Egymedicalpedia
Melasma, Melasma (Facial Melasma)
Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma
The data will be collected after the permission of the ethical committee of hospital. Following the enrollment, patients will be selected by lottery in the two equal groups.
- Trial name
- NCT07732192
- Testing
- Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone
- Volunteers
- 128 people
- Sponsor
- Combined Military Hospital Abbottabad
Healthy
A Study to Assess Effect of Two Facial Sunscreens in Improving Wrinkles, Fine Lines and Melasma in Adult Participants
The purpose of this study is to evaluate the topical safety (tolerability/acceptability) and efficacy of two facial sunscreen in improving wrinkles, fine lines and melasma after 84 +/- 2 days of use under normal conditions on the…
- Trial name
- NCT05864417
- Testing
- Sunscreen Color tone 2.0, Sunscreen Color tone 3.0
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Melasma
Tranexamic Acid vs. Combination With Fractional Carbon Dioxide Laser in Melasma
The objective of this study is to assess and compare the efficacy of tranexamic acid intradermal microinjection alone versus its combination with low power fractional CO2 laser in a sequential pattern.
- Trial name
- NCT03899233
- Testing
- Fractional CO2 laser, Tranexamic acid intradermal microinjections
- Volunteers
- 25 people
- Sponsor
- Cairo University
Melasma, Post-acne Hyperpigmentation
Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES
The goal of this clinical trial is to evaluate the efficacy and safety of a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES when used as a moisturizer after QS-Nd:YAG 1064 nm low-fluence laser…
- Trial name
- NCT07121439
- Testing
- a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES, 2% hydroquinone cream
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)