Clinical trials: Melasma
Melasma
USE THE SYSTEMIC METFORMIN IN MELASMA
Melasma is a chronic and relapsing acquired dyschromia due to an increased epidermal-melanin unit activity that affects sun-exposed areas mainly in women throughout the reproductive years.
- Trial name
- NCT03475524
- Testing
- MetFORMIN 1000 Mg Oral Tablet, Trichloroacetic Acid Peeling, MetFORMIN 500 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Melasma
Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma
To determine the effectiveness and safety of sequential therapy with of Tri-Luma® Cream and a series of Glycolic Acid peels in treatment of moderate to severe melasma.
- Trial name
- NCT00472966
- Testing
- Fluocinolone acetonide 0.1%/hydroquinone 4%/tretinoin 0.05% Cream in sequence with glycolic acid peels
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Galderma R&D
Melasma
Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration
Melasma is a refractory skin disease due to its complex pathogenesis and difficult treatment. Studies have found that human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) could serve as a novel cell-free…
- Trial name
- NCT06221787
- Testing
- 1565 nm non-ablative fractional laser combined with normal saline, microneedles combined with hUCMSC-Exos, 1565 nm non-ablative fractional laser combined with hUCMSC-Exos
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Melasma
Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma
Microneedling radiofrequency technology has been shown in clinical studies to improve skin quality, tone, pigment, and to treat various skin conditions related to aging.
- Trial name
- NCT06415435
- Testing
- Radiofrequency Microneedling
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benev Company, Inc.
Melasma
Efficacy of Platelet-rich Plasma in Treatment of Melasma
The application of Platelet Rich Plasma (PRP) on three occasions with an interval of 15 days between each one, is related to a decrease in the intensity of the spots and improvement in the quality of the skin of patients with…
- Trial name
- NCT03674203
- Testing
- Platelet-Rich Plasma
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Mexicano del Seguro Social
Skin Diseases, Skin Disorder
OneDoc Picopulse™ for the Treatment of Melasma Among Malaysian Women
OneDoc Picopulse™ is a radiopulse technology beauty grade device invented for treating melasma.
- Conditions
- Skin Diseases, Skin Disorder, Melanoma (Skin)
- Trial name
- NCT04834167
- Testing
- OneDoc Picopulse
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- Universiti Tunku Abdul Rahman
Melasma
Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid
Melasma is a common acquired disorder of hyperpigmentation characterized by irregular light brown to dark brown patches of hyperpigmentation commonly affecting the face. The trunk and arms are also occasionally involved .
- Trial name
- NCT03153852
- Testing
- Modified Jessner's solution, Glycolic acid, Trichloroacetic acid
- Volunteers
- 30 people
- Sponsor
- Assiut University
Melasma
Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma
The purpose of this prospective, randomized, controlled, single-blinded investigation is to study the efficacy, tolerability and safety of azelaic acid iontophoresis (AAI) versus topical treatment with azelaic acid cream in…
- Trial name
- AAI (NCT00848458)
- Testing
- Iontophoresis, Azelaic acid cream
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Medical University of Vienna
Melasma
Prevention of Melasma Relapse During Summertime
Main objective is to show that a photoprotective sunscreen having a protection against the visible light is more effective than a sunscreen having the same UVA AND UVB protection but with a low (weak) protection against the…
- Trial name
- NCT02061839
- Testing
- Sunscream with visible light protection, Sunscream
- Volunteers
- 40 people
- Sponsor
- Centre de Pharmacologie Clinique Applique a la Dermatologie
Melasma
Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma
This study is to compare the efficacy of topical tranexamic acid vs topical ethyl ascorbic acid in the treatment of melasma
- Trial name
- NCT07522788
- Testing
- Ethyl ascorbic acid topical application, Tranxemic acid topical application
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Melasma, Chloasma
Oral and Topical Tranexamic Acid for the Treatment of Melasma
Tranexamic acid has been used for treating melasma due to its effect on decreasing the activity of tyrosinase and melanogenesis.
- Conditions
- Melasma, Chloasma, Melanosis
- Trial name
- TRANEXAMICO (NCT03585179)
- Testing
- Oral Tranexamic Acid, 5% topical tranexamic acid, 4% hydroquinone
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Centro Dermatológico Dr. Ladislao de la Pascua
Melasma
Oral Tranexamic Acid and Laser for Treatment of Melasma
Tranexamic acid and 1927 diode laser non-ablative fractionated laser for the treatment of Melasma.
- Trial name
- NCT03686787
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laser and Skin Surgery Center of New York
Melasma
COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA
Melasma is a common acquired hyperpigmentation disorder that significantly affects quality of life. Various topical agents are used in its treatment, including Vitamin C and Niacinamide, both of which possess depigmenting…
- Trial name
- NCT07890571
- Testing
- Ascorbic acid, niacinamide
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pak Emirates Military Hospital
Melasma
LaseMD System for the Treatment of Melasma
This study will evaluate the clinical outcomes associated with use of the LaseMD Laser System for the treatment of melasma.
- Trial name
- NCT03456674
- Testing
- LaseMD System
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CynosureLutronic
Melasma
A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating of Melasma.
1.Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types.
- Trial name
- NCT03963466
- Testing
- tranexamic acid, 1064-nm Q-Switched fractional laser, 1064-nm Q-Switched laser
- Where
- China
- Volunteers
- 30 people
- Sponsor
- xjpfW
Melasma, Treatment of Stable Melasma
Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment of Melasma
Melasma is a common pigmentation disorder among young and middle-aged women, characterized by symmetrical brown-black patches on the face.
- Conditions
- Melasma, Treatment of Stable Melasma, Tranexamic Acid, Laurocapram
- Trial name
- NCT07530016
- Testing
- Ligustrazine - tranexamic acid - aloe polysaccharide composite gel
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Melasma
Melanil in the Treatment of Melasma
The purpose of the study is to assess the efficacy of Melanil facial cream in the treatment of melasma. The duration of this double-blind phase 3 clinical trial will be 54 weeks.
- Trial name
- NCT01001624
- Testing
- Melanil facial cream, Hydroquinone 2% cream
- Where
- Cuba
- Volunteers
- 150 people
- Sponsor
- Catalysis SL
Melasma
Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study
1. To evaluate the efficacy and safety of topical resveratrol 1 % gel in treatment of melasma. 2. To compare between the efficacy of topical resveratrol 1 %gel versrs chemical peeling with TCA 20% in melasma.
- Trial name
- NCT07060157
- Testing
- resveratrol 1 % gel, TCA20%
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Assiut University
Melasma
Comparative Study of Dual Yellow Laser Versus Stabilized Kilnman Preparation in the Treatment of Melasma
Recent data highlight the role of vascularity in melasma and a recent study showed the interest to target this vascular component by pulsed dye laser.
- Trial name
- NCT01850186
- Testing
- Dual yellow Laser, Stabilized kilnman trio
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Melasma, Platelet Rich Plasma
Platelet Rich Plasma in Treatment of Melasma
Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The therapy for melasma has always been challenging and discouraging.
- Trial name
- NCT03308370
- Testing
- Platelet rich plasma
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Assiut University