Clinical trials: Medication Side Effects
Child With Adverse Drug Reactions
Adverse Drug Reactions in Pediatrics: Experience of a Regional Pharmacovigilance Center
Aim. - To describe the adverse drug reactions (ADR) and the drugs involved in pediatrics. Methods. - An observational study on all ADR notifications recorded in the French pharmaco-vigilance database by the Regional…
- Trial name
- Pediatry ADR (NCT03316014)
- Testing
- Adverse drug reaction
- Volunteers
- 632 people
- Sponsor
- CHU de Reims
Multiple Sclerosis
Evaluating the Use of Prednisone to Decrease Pegylated Interferon Beta-1a Side Effects
Some of the most common side effects of the multiple sclerosis drug Plegridy (pegylated interferon beta-1a) include flu-like symptoms and injection site reactions.
- Trial name
- NCT03424733
- Testing
- Plegridy, Prednisone, Tylenol Pill
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Holy Name Medical Center, Inc.
Drug Reaction to Analgesic Nos
Phase I Pharmacokinetic Study of RX0041-2
This Phase I study is to examine the systemic pharmacokinetics of RX0041-002 following acute, topical, intranasal administration to healthy male and female volunteers.
- Trial name
- NCT02667106
- Testing
- RX0041-2
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharmaceutical Project Solutions, Inc.
Latent Tuberculosis Infection
Adverse Drug Reactions to Anti-TB Drugs in the Treatment of Latent Tuberculosis Infection
The investigators aim to study the prevalence of adverse reactions of anti-tuberculosis (TB) drugs in latent tuberculosis infection (LTBI), and determine the risk factors of anti-TB drug-related toxicity in LTBI in Korean health…
- Trial name
- NCT03312647
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Hanyang University
Adverse Drug Event
Monitoring of Metabolic Adverse Events of Second Generation Antipsychotics in a Naive Pediatric Population
Introduction: Second Generation Antipsychotics (SGAs) are widely used in the pediatric population. It is currently established that SGAs may induce undesirable metabolic adverse events (AEs) such as weight gain, metabolic changes…
- Trial name
- MEMAS (NCT04395326)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- St. Justine's Hospital
Bone and Joint Infection, Osteomyelitis
Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection
The aim of this study is to adescription of mandibular osteomylitis in patients having had a treatment by DENOSUMAB. Indeed, one of the adverse effect ot this molecule is to induce mandibular infection.
- Conditions
- Bone and Joint Infection, Osteomyelitis, Adverse Drug Event
- Trial name
- NCT03808285
- Testing
- mandibular osteomylitis
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Hospices Civils de Lyon
Chemotherapy-Related Cognitive Impairment, Breast Cancer
GM1 Prophylaxis for Post-chemotherapy Cognitive Impairment in Patients With Early Operable Breast Cancer
The purpose of this study is to evaluate the prophylactic effects of Ganglioside-Monosialic Acid in post-chemotherapy cognitive impairment in patients with early operable breast cancer.
- Trial name
- NCT05239663
- Testing
- Ganglioside-Monosialic Acid, 250ml normal saline (NS)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Sun Yat-sen University
HIV-1-infection, Antiviral Drug Adverse Reaction
Contribution of Dolutegravir to Obesity and Cardiovascular Disease
The goal of the study is to combine a collaborative and translational approach to evaluate the effect antiretroviral regimen switch to a dolutegravir containing regimen compared to continued treatment with a non- dolutegravir…
- Conditions
- HIV-1-infection, Antiviral Drug Adverse Reaction, Vascular Diseases, Cardiovascular Abnormalities
- Trial name
- NCT04340388
- Testing
- Dolutegravir 50 MG, Antiretroviral/Anti HIV
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Augusta University
Symblepharon, Dry Eye
Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome.
The purpose of this study is to evaluate salivary gland and labial mucous membrane transplantation in patients with severe symblepharon and dry eye secondary to Stevens-Johnson Syndrome (SJS).
- Conditions
- Symblepharon, Dry Eye, Ocular Surface Disease, Transplantation
- Trial name
- NCT01178242
- Testing
- Salivary Gland and Labial Mucous Membrane Transplantation
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Federal University of São Paulo
Cardiotoxicity
Staccato Prochlorperazine Thorough QT/QTc
To assess the safety of Staccato Prochlorperazine on cardiac repolarization (QTc interval duration) at 2 dose levels compared to placebo in healthy volunteers.
- Trial name
- NCT00543062
- Testing
- Inhaled prochlorperazine 5 mg, Inhaled prochlorperazine 10 mg, Oral moxifloxacin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Maculopathy
" En Face " OCT's Contribution in the Detection of Macular Retinal Toxicity Signs Linked to the Chronic Treatment of Synthetic Antimalarials
The maculopathy induced by the retinal toxicity of the synthetic antimalarials must be detected at the infra-clinical state, when it can still be reversible.
- Trial name
- OCTAPS (NCT02805686)
- Testing
- spectral domain optical coherence tomography, multifocal electroretinogram
- Volunteers
- 45 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Atrial Fibrillation New Onset
Radiotherapy-Associated Atrial Fibrillation
Radiotherapy associated Atrial Fibrillation (RADAF) is an observational study to evaluate onset time and frequency of atrial fibrillation in patients with thoracic malignancies and breast cancer.
- Trial name
- RADAF (NCT05927246)
- Testing
- ECG
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Istanbul University
HIV Infections, Hepatitis C, Chronic
Treatment of Chronic Hepatitis C With PEG Interferon alfa2a and Ribavirin in HIV-infected Patients
Combination of PEG interferon and ribavirin is the standard treatment of chronic hepatitis C. Efficacy of this treatment has never been evaluated in HCV-HIV infected patients, who have previously been treated with a first line…
- Conditions
- HIV Infections, Hepatitis C, Chronic, Treatment Failure
- Trial name
- ROCO2 (NCT00221650)
- Testing
- Peginterferon alfa2a, Ribavirin
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Bordeaux
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Drug-induced Liver Injury,Chronic
Efficacy and Safety of Glucocorticosteroid Treatment in the Patients With Chronic Recurrent DILI
This study is to observe the efficacy and safety of glucocorticosteroid treatment in the patients with chronic recurrent drug-induced liver injury (DILI).
- Trial name
- NCT02651350
- Testing
- Methylprednisolone, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing 302 Hospital
Graft vs Host Disease, Mesenchymal Stem Cell Transplantation
Use of Bone Marrow Stem Cells (MesenCell) for the Treatment of Patients With Chronic Graft-versus-host Disease
The purpose of this Phase I clinical trial is to evaluate the safety and potential treatment response of bone marrow-derived mesenchymal stem cells (MesenCell) in adult patients with moderate or severe chronic graft-versus-host…
- Trial name
- NCT07826676
- Testing
- Mesenchymal Stem Cell Infusion
- Where
- 4 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Chemical Injuries, Unspecified Complication of Corneal Transplant
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
The purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for…
- Conditions
- Chemical Injuries, Unspecified Complication of Corneal Transplant, Autoimmune Diseases, Ocular Cicatricial Pemphigoid
- Trial name
- NCT01582880
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph B. Ciolino, MD
Hand and Foot Syndrome
TAR-0520 Gel in Hand and Foot Syndrome
Hand and Foot Syndrome (HFS) is a weii-established and frequent cutaneous adverse event of capecitabine used in the treatment of different cancers.HFS is charectirized by a variety of symptoms ranging from mild discomfort to a…
- Trial name
- TARIAN008 (NCT07457671)
- Testing
- TAR-0520 gel
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Tarian Pharma
Non Small Cell Lung Cancer, Nephropathy
Effect of Genetic and Epigenetic Factors on the Clinical Response and Toxicity to Cisplatin Among Egyptian Non-small Cell Lung Cancer Patients
Lung cancer is the leading cause of death worldwide, with non-small-cell lung cancer (NSCLC) being the most common histotype according to the global cancer observatory 2022.
- Conditions
- Non Small Cell Lung Cancer, Nephropathy, Cardiotoxicity
- Trial name
- NCT05746598
- Testing
- Cisplatin injection
- Where
- Egypt
- Volunteers
- 178 people
- Sponsor
- Ain Shams University
Heart Failure, Metabolic Alkalosis
Metabolic Alkalosis in Heart Failure
Metabolic alkalosis (MA) is the most common acid-base disorder and when it's severe it can have effects on cellular function and contribute to an increase in mortality.
- Conditions
- Heart Failure, Metabolic Alkalosis, Diuretics Drug Reactions, Decompensated Heart Failure
- Trial name
- NCT04740242
- Where
- Spain
- Volunteers
- 672 people
- Sponsor
- Spanish Society of Internal Medicine