Clinical trials: Medication Side Effects
Breast Cancer, Cardiotoxicity
Understanding CARdiac Events in Breast Cancer
In Ireland, over 3,000 patients are diagnosed with breast cancer annually, and 1 in 9 Irish women will be diagnosed with breast cancer in their lifetime.
- Conditions
- Breast Cancer, Cardiotoxicity, Cardiomyopathies, Chemotherapeutic Toxicity
- Trial name
- UCARE (NCT05921279)
- Where
- 4 sites in Ireland
- Volunteers
- 100 people
- Sponsor
- National University of Ireland, Galway, Ireland
Adverse Mental/Physical Effects of Low Dose S. Tortuosum.
Safety Study of the Effect of Scelectium Tortuosum (as Zembrin®)in Aged Normals
Phosphodiesterase is a candidate for the Rx \& prevention of cognitive and psychotic disorders. Since caffeine targets primarily PDE4(Phosphodiesterase subtype 4), caffeine analogs have been developed to mimic the actions of…
- Trial name
- NCT01805518
- Testing
- Scelectium Tortuosum
- Where
- Puerto Rico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Woodbury, Michel, M.D.
Drug Induced Liver Injury
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver.
- Trial name
- Non-Drinker (NCT00616018)
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kennon Heard
Chemotherapy-Related Cognitive Impairment, Healthy
Telerehabilitation Cognitive Impairments Following Chemotherapy Usability Study
Develop a game-based upper-extremity motor and cognitive rehabilitation system using custom and adaptable virtual reality simulations.
- Trial name
- TCIFCU (NCT04839588)
- Testing
- Usability study
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bright Cloud International Corp
Interdisciplinary Communication, Management, Medication Therapy
Minimizing Harm From ADEs by Improving Nurse-Physician Communication
The purpose of this research study is to examine the clinical processes of care involved with the sharing and communicating of medication management information in the inpatient setting between nurses, pharmacists and physicians.
- Trial name
- MED-COMM (NCT00574990)
- Where
- 3 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Drug-induced Extrapyramidal Side Effects
Extrapyramidal Side-Effects in Antipsychotic Drug Therapeutics
The project is aimed at addressing the fundamental issue in antipsychotic therapeutics -the balance between mental state benefits and neurological risks.The latter cannot be overestimated and clinical skills in themselves are…
- Trial name
- NCT02366897
- Testing
- Manus Sensor Pen
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Edinburgh
Myotoxicity
Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty
Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia.
- Trial name
- NCT05505890
- Testing
- suprainguinal fascia iliaca block
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Samsun University
Schizophrenia, Major Depressive Disorder
Clinical Registry of Patients Under Treatment With Atypical Antipsychotics
Antipsychotic drugs are characterized by blocking dopaminergic D2 receptors. They have been found to be effective and safe for the treatment of schizophrenia, bipolar disorders, depressive episodes associated with bipolar…
- Conditions
- Schizophrenia, Major Depressive Disorder, Bipolar Depressive Disorder, Parkinson's Disease With Hallucinations
- Trial name
- NCT02409823
- Testing
- Atypical Antipsychotics
- Volunteers
- 665 people
- Sponsor
- Pontifical Catholic University of Argentina
Adverse Drug Events
Patient Profiling and Provider Feedback to Reduce Adverse Drug Events
Adverse drug events (ADE) present a unique focus for error reduction. Computerized provider order entry, with embedded clinical decision support, has great promise in reducing medication errors but preventable adverse drug events…
- Trial name
- NCT00013143
- Testing
- Patient risk profiling (potential ADEs) w/provider feedback
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- US Department of Veterans Affairs
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Hospitalization
Reducing Transition Drug Risk
Patient transfer between sites of care is regular practice during an episode of care in our current health care system. Yet inter-site transfer is associated with lapses in care quality that adversely affect patient outcomes.
- Trial name
- NCT00370916
- Testing
- Physician-initiated medication reconciliation, Pharmacist-initiated medication reconciliation
- Where
- United States
- Volunteers
- 612 people
- Sponsor
- US Department of Veterans Affairs
Leishmaniasis; American, Cutaneous, Drug Side Effect
Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients
It is a randomized phase II clinical study, unicentre aimed to evaluate the tolerability, safety and efficacy of 18-Methoxyoronaridine as a candidate of tegumentary leishmaniasis treatment.
- Trial name
- NCT03084952
- Testing
- 18-Methoxycoronaridine, Glucantime
- Volunteers
- 52 people
- Sponsor
- Infan Industria Quimica Farmaceutica Nacional
Multiple Sclerosis
Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in Combination
This study will primarily address the question whether the combination of Mitoxantrone therapy with dexrazoxane can reduce cardiotoxic side effects in the treatment of Multiple Sclerosis patients in comparison to Mitoxantrone…
- Trial name
- MSCardioPro (NCT01627938)
- Testing
- Dexrazoxane (DRZ) plus Mitoxantrone (MX)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- PD Dr. Andrew Chan
Osteosarcoma, Survival
Comparison of MAPI+Camrelizumab Versus API+Apatinib Versus MAPI in Patients With a Poor Response to Preoperative Chemotherapy for Newly Diagnosed High-grade Osteosarcoma
Treatment strategies for high-grade osteosarcoma with multidrug chemotherapy and resection result in 3-year event-free survival of 60-70%.
- Conditions
- Osteosarcoma, Survival, Chemotherapy Effect, Toxicity, Drug
- Trial name
- MAPAC (NCT04351308)
- Testing
- MAPI chemotherapy, Apatinib Mesylate, Camrelizumab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Target Drug-related Adverse Events
Standard of Care Versus Urine Testing With Selective PHarmacogenomics for Effective Drug and Dosing REgimens
The purpose of this study is to determine whether the addition of selective pharmacogenomic (PGx) testing as determined by Urine Drug Testing (UDT) adds a clinical benefit as evidenced by a reduction in Target Drug-related…
- Trial name
- SPHERE (NCT02625155)
- Testing
- Urine diagnostic testing as SOC, drug regimen changes per SOC, Urine diagnostic testing with selective PGx testing, drug regimen changes based on PGx test results
- Where
- United States
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- InSource Diagnostics
Patients on Anti-hypertensive Medication
Impact of a Procedure for the Information and Active Participation of the Patient in the Primary Care Prescription of Antihypertensives
Adverse drug events (ADEs) are responsible for 3.6% of the hospitalisations in France. 50% of these ADEs could be preventable. Cardiovascular drugs are frequently involved in ADEs.
- Trial name
- InPAct (NCT01610817)
- Testing
- InPAct : Information for Participating Actively in cardiovascular treatment
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- Hospices Civils de Lyon
Simvastatin Adverse Reaction, Pharmacogenomics
A Pharmacogenomics Study of Simvastatin-Induced Adverse Drug Reaction
Adverse reactions of simvastatin are mostly slight and transient, however, the incidence of simvastatin-induced hepatic impairment and myopathy are obviously higher in Chinese population than other racial groups.
- Conditions
- Simvastatin Adverse Reaction, Pharmacogenomics, Accurate Medication
- Trial name
- NCT03261908
- Testing
- detection of genotype
- Where
- China
- Volunteers
- 2,200 people
- Sponsor
- Cui Yimin
Aortic Stenosis, Chemotherapy Induced Systolic Dysfunction
Fibrosis in Chronic and Delayed Myocardial Infarction
In this study the investigators aim to examine the role that fibrosis plays in heart conditions such as aortic stenosis , chemotherapy-induced cardiotoxicity and carcinoid syndrome .
- Conditions
- Aortic Stenosis, Chemotherapy Induced Systolic Dysfunction, Carcinoid Syndrome
- Trial name
- FCDMI (NCT05756608)
- Testing
- 68Ga-FAPI and 18F-AlF-FAPI PET-MR
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Clinical Efficacy and Safety
The Efficacy and Adverse Reactions of Neotetracycline in the Treatment of GNB Infections
A multicenter, retrospective, real-world stduy . Subjects with composite criteria were teated with eravacycline ,and 100 cases ,Tigecycline and 300 cases were to be enrolled.
- Trial name
- NCT06990126
- Testing
- bronchoscope
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Obesity; Drug
Nutritional Therapy to Incretin-based Anti-obesity Medications in the Management of Gastrointestinal Adverse Events
The goal of the study is to evaluate the effect of nutrition intervention on gastrointestinal symptoms, treatment discontinuation rate, nutritional parameters (e.g., dietary intake and eating habits), anthropometric measures…
- Trial name
- NCT06431308
- Testing
- nutritional intervention
- Where
- 3 sites in Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ariel University