Clinical trials: Medication Side Effect
Graves Disease, Graves Ophthalmopathy
Liver Function After Intravenous Methylprednisolone Administration
Graves' orbitopathy (GO) is a characterized by orbital soft tissue inflammation and oedema associated with glycosaminoglycan deposition and fibrosis. The most frequent cause is Graves' disease.
- Conditions
- Graves Disease, Graves Ophthalmopathy, Liver Diseases, Liver Failure
- Trial name
- NCT03667157
- Testing
- every week IVMP therapy, very high doses IVMP therapy
- Volunteers
- 68 people
- Sponsor
- Medical University of Warsaw
Carcinoid Tumors
Study Evaluating SOM230 in Patients With Metastatic Carcinoid Tumors
Study evaluating SOM230 in patients with metastatic carcinoid tumors
- Trial name
- NCT00088595
- Testing
- Pasireotide (SOM230)
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Radiotherapy
BRAVE-HEART: Breast Cancer Radiotherapy Using Active Breathing Coordinator to aVoid Exposure of HEART
The BRAVE-HEART trial is an ambispective, observational, non-randomized study conducted at Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Policlinico San Matteo (Pavia, Italy).
- Trial name
- BRAVE-HEART (NCT07299812)
- Testing
- Breast Radiotherapy with or without Deep Inspiration Breath Hold (DIBH)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiotoxicity, Breast Cancer
PROactive Evaluation of Function to Avoid CardioToxicity
This study is intended to evaluate the ability of an intramyocardial strain analysis package with cardiac MRI to assist in the early detection and management of cardiotoxicity from therapeutics used to treat cancer.
- Conditions
- Cardiotoxicity, Breast Cancer, Lymphoma, Sarcoma
- Trial name
- PROACT (NCT03862131)
- Testing
- MyoStrain®
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Washington University School of Medicine
Drug-Induced Liver Injury
A Retrospective Study on Drug Induced Liver Injury in China
This is a multi-center, open-enrollment, retrospective, non-interventional epidemiologic study without any clinical treatment. Its primary objective is to understand 1) incidence of drug-induced liver injury, including incidences…
- Trial name
- DILI-R (NCT02407964)
- Where
- 371 sites in China
- Volunteers
- 15,000 people
- Sponsor
- Drug Induced Liver Disease Study Group
Hiv, HIV Infections
Changes in Weight, Body Composition and Cardiac Risk After Discontinuing Abacavir Treatment in HIV-infected Individuals
Randomized controlled parallel open-label study in people living with HIV and at least 6 month of treatment with dolutegravir/abacavir/lamivudine prior to inclusion.
- Conditions
- Hiv, HIV Infections, HIV Cardiomyopathy, Weight Change, Body
- Trial name
- AVERTAS (NCT04904406)
- Testing
- Dolutegravir / Lamivudine Oral Tablet
- Where
- 2 sites in Denmark
- Volunteers
- 81 people
- Sponsor
- Thomas Benfield
Carcinoid Syndrome
Effects of Serotonin Excess on Bone in Carcinoid Syndrome
Serotonin has recently been identified as a major regulator of bone formation. Gut-derived serotonin inhibits bone formation, and early animal studies have shown that inhibition of gut-derived serotonin has anabolic effects on…
- Trial name
- NCT01430871
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Allergy, Allergy;Food
Allergy Diagnostic Test Based on Microchip Technology
The purpose of this study is to develop a microarray-based diagnostic test system for the determination of allergen specific IgE in human blood serum.
- Conditions
- Allergy, Allergy;Food, Allergy Pollen, Allergy Drug
- Trial name
- NCT06167564
- Testing
- Routine allergy tests, Newly developed microarray-based diagnostic test system
- Where
- Belarus
- Volunteers
- 400 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Primary Health Care, Telemedicine
Proactive Telemedicine to Improve Healthcare Access and Prevention in Rural Primary Care (PTM)
The study evaluates whether Proactive Telemedicine (PTM) can improve healthcare access for individuals who have not contacted their primary care team for at least one year, compared with face-to-face visits.
- Conditions
- Primary Health Care, Telemedicine, Face to Face Consultation, Health Care Access
- Trial name
- PTM (NCT07299201)
- Testing
- Telemedicine Brief Behavioural Lifestyle Intervention, Face to face Brief Behavioural Lifestyle Intervention
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Cardiac Toxicity, Early-stage Breast Cancer
Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted
This study proposes that the addition of statins reduces the treatment delays or early discontinuations secondary to cardiotoxicity in patients with Stage I-III HER2 positive breast being treated with anti-HER2 therapy.
- Trial name
- NCT05559164
- Testing
- Lipitor 40mg Tablet
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Adverse Effect of Drugs and Medicaments in Therapeutic Use, Adverse Effects in the Therapeutic Use of Anaesthetics
The Effect of Opioid Free Anesthesia in Bariatric Surgeries
This is a prospective randomized controlled study that will be carried out on morbid obese patients admitted to Tanta University hospitals for laparoscopic bariatric surgeries.
- Trial name
- Opioidfree (NCT04048200)
- Testing
- Fentanyl, Dexmedetomidine Ketamine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Blood Pressure, Diabetes
Mitigating the Pro-inflammatory Phenotype of Obesity
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell…
- Conditions
- Blood Pressure, Diabetes, Obesity, Insulin Resistance
- Trial name
- MAPLE (NCT04934228)
- Testing
- Hydrochlorothiazide 12.5Mg Tab, Clonidine Pill
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kansas Medical Center
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Capsule.
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Capsule (XLGB Capsule) through a non-intervention observational way.
- Trial name
- NCT03091244
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD)
Vestibular Implantation in Older Adults
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural…
- Conditions
- Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth Diseases
- Trial name
- NCT05676944
- Testing
- Labyrinth Devices MVI™ Multichannel Vestibular Implant System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Overactive Bladder (OAB), Drug Delivery Systems
Transdermal Versus Oral Oxybutynin in Pediatric OAB
This is a prospective, randomized controlled clinical trial designed to compare the efficacy and safety of transdermal versus oral oxybutynin in children diagnosed with overactive bladder (OAB) who remain symptomatic despite…
- Conditions
- Overactive Bladder (OAB), Drug Delivery Systems, Anticholinergic Side Effects, Children and Adolescents, Boys and Girls
- Trial name
- NCT07081906
- Testing
- Oral Oxybutynin, transdermal oxybutinin
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Carcinoid Syndrome
Study of Telotristat Etiprate (LX1606) in Participants With Symptomatic Carcinoid Syndrome
The purpose of the study is to evaluate the safety and tolerability of orally administered telotristat etiprate (LX1606) in participants with symptomatic carcinoid syndrome.
- Trial name
- NCT01104415
- Testing
- Telotristat etiprate
- Where
- 10 sites in Germany, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Lexicon Pharmaceuticals
Non-Small Cell Lung Cancer (MeSH Term: Carcinoma, Non-Small-Cell Lung), Drug-Related Side Effects and Adverse Reactions (MeSH Term)
Cancer Therapy-Related Cardiac Dysfunction Associated With EGFR-TKIs in Advanced EGFR-mutant Non-small Cell Lung Cancer
This study investigated the incidence of cardiac dysfunction in patients with advanced or recurrent epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer treated with EGFR- tyrosine kinase inhibitors.
- Conditions
- Non-Small Cell Lung Cancer (MeSH Term: Carcinoma, Non-Small-Cell Lung), Drug-Related Side Effects and Adverse Reactions (MeSH Term), Egfr Tyrosine Kinase Inhibitor, Cardiotoxicity
- Trial name
- NCT07267247
- Testing
- EGFR-TKI, EGFR tyrosine kinase inhibitor
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taichung Veterans General Hospital
Chemotherapy-related Cognitive Impairment
Evaluating Cognitive Changes on Patients in Chemotherapy (ECCPC)
This randomized clinical trial aims to evaluate the impact of a structured low-intensity exercise program on cognitive function in adult cancer patients undergoing chemotherapy.
- Trial name
- (ECCPC) (NCT06950190)
- Testing
- Low-Intensity Walking Intervention, Control Group Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ellis Medicine
Non Small Cell Lung Cancer, Cardiotoxicity
Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Prospective clinical study designed to evaluate damage to the heart after receiving standard of care chemotherapy and radiation therapy for locally advanced Non-Small Cell Lung Cancer (NSCLC).
- Conditions
- Non Small Cell Lung Cancer, Cardiotoxicity, Locally Advanced Non-Small Cell Lung Cancer, Radiation Therapy
- Trial name
- NCT07761910
- Testing
- PET/CT 18F-Flurpiridaz Rest/Stress Test, Coronary CT Angiography (CCTA), 18F-Flurpiridaz
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Drug Hypersensitivity
Cephalosporin Hypersensitivity
Background : Although the hypersensitivity reactions to cephalosporins have been recently a more focused subject, studies on the cephalosporin as an allergen are significantly less frequent that those regarding penicillins.
- Trial name
- CephALL (NCT04421638)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier