Clinical trials: Mechanical Ventilation Complication
Oral Bacterial Infection, Mechanical Ventilation Complication
Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study
We propose a randomized pilot/feasibility study comparing oral care treatment as usual (TAU) with Swiftsure SwishKit plus oral care TAU on the presence and magnitude of bacterial load in the oropharyngeal space in orotracheally…
- Trial name
- EASIER (NCT06193512)
- Testing
- SwishKit + Oral care treatment as usual, Oral care treatment as usual
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Cleveland Clinic
Weaning Failure, Mechanical Ventilation Complication
Development of a Multimodal Index to Improve the Predictive Value of Success in Weaning From Mechanical Ventilation
Weaning from mechanical ventilation (MV) is a complex process in which patients are liberated from the ventilator. Prolongued weaning and weaning failure, defined as the need for reintubation, have different adverse effects…
- Trial name
- NCT04554095
- Testing
- Clinical data collection
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli
Respiratory Insufficiency, Respiratory Failure
Entrainment-Based Mechanical Ventilation
BACKGROUND AND SIGNIFICANCE Entrainment-based ventilation is a new mode of mechanical ventilation based on the classical physics theory of mutual entrainment between coupled oscillators.
- Conditions
- Respiratory Insufficiency, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- NCT03512067
- Testing
- Patients given EMV Ventilation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brigham and Women's Hospital
Surgery, Mechanical Ventilation Complication
Re-Evaluation of the Effects of High PEEP During General Anesthesia For Surgery (REPEAT)
Aiming to understand the isolated impact of high PEEP in patients undergoing mechanical ventilation for general anesthesia for surgery, three appropriately sized international multicentre randomized controlled trials have been…
- Conditions
- Surgery, Mechanical Ventilation Complication, Pulmonary Complication
- Trial name
- REPEAT (NCT03937375)
- Testing
- High PEEP, Low PEEP
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 3,837 people
- Sponsor
- Hospital Israelita Albert Einstein
Diaphragm Injury, Respiratory Failure
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
- Conditions
- Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- DIASPORA (NCT03667027)
- Testing
- Respiratory support
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cardiopulmonary Arrest, Mechanical Ventilation Complication
Evaluating the Performance of Invasive Ventilation During Specialized CPR
Describe the ventilation patterns, describe the evolution of ventilation over time and describe the safety data for two strategies of ventilation (volume or pression modes) during specialized cardiopulmonary resuscitation of…
- Trial name
- NCT06175689
- Volunteers
- 400 people
- Sponsor
- University Hospital, Angers
Anesthesia, Surgery--Complications
Intraoperative Protective Ventilation for Obese Patients Undergoing Gynaecological Laparoscopic Surgery
Background. The use of a comprehensive strategy providing low tidal volumes, peep and recruiting maneuvers in patients undergoing open abdominal surgery improves postoperative respiratory function and clinical outcome.
- Trial name
- Inprove4large (NCT03157479)
- Testing
- Intravenous anesthetic, Crystalloid Solutions, Esophageal pressure measurement
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Mechanical Ventilation Complication, Upper Airway Obstruction
Nasal Mask Ventilation During the Induction of General Anesthesia
Recently, the investigators demonstrated that nasal route ventilation is superior to the nasal-oral combined ventilation in the absence of jaw thrust and chin up maneuvers.
- Trial name
- NCT01651286
- Testing
- nasal mask, full face mask
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Early Diagnosis of ARDS in Mechanically Ventilated Patient Using LUS Score in Comparison With CT
The aim of this study is to assess accuracy of Lung ultrasound score for early diagnosis of acute respiratory distress syndrome in patients who expected to be mechanically ventilated more than 24 hour in comparison with computed…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Computed Tomography
- Trial name
- NCT06971042
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Tanta University
Mechanical Ventilation Complication
Potential Impact of the Use of the Application VentilO
Mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock.
- Trial name
- NCT05587686
- Testing
- VentilO application
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Acute Kidney Injury
Spironolactone on Acute Kidney Injury in Critically Ill Patients
This study was designed to evaluate the effect of spironolactone administration in the incidence and severity of AKI in patients critically ill with invasive mechanical ventilation (IMV) in the critical care unit.
- Trial name
- NCT03206658
- Testing
- Spironolactone 25 mg
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mechanical Ventilation Complication
Heartrate Variability During Conventional and Variable Pressure Support Mechanical Ventilation
Rationale Studies show that about a third of all postoperative complications are due to cardiovascular reasons. Furthermore it was shown that more than 50% of postoperative deaths are associated with severe cardiovascular…
- Trial name
- NCT03360968
- Testing
- Variable-PS, SPN-CPAP/PS
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Anesthesia, Postoperative Complications
Evaluation of V/Q Mismatch as Predictor of Pulmonary Postoperative Complications in Patients Undergoing Major Surgery
Pulmonary postoperative complications (PPC) are among the main causes of surgical complications affecting both postoperative morbidity and mortality.
- Conditions
- Anesthesia, Postoperative Complications, Mechanical Ventilation Complication
- Trial name
- VQppc (NCT05454917)
- Testing
- Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Università degli Studi di Ferrara
Deglutition Disorders, Mechanical Ventilation Complication
PReventing the EffectS of Intubation on DEglutition
An early intervention for swallowing disorders (i.e., dysphagia) during endotracheal intubation may improve patient outcomes. The investigators propose treatment sessions targeting sensorimotor integration, strength, and range of…
- Conditions
- Deglutition Disorders, Mechanical Ventilation Complication, Complication of Ventilation Therapy
- Trial name
- PRESIDE (NCT02442102)
- Testing
- Exercise and sensory stimulation
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Obesity, Obesity With Complications
Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients
ICU patients encounter numerous discomforts, with dyspnea (the sensation of breathlessness) being among the most distressing and impactful.
- Conditions
- Obesity, Obesity With Complications, Weaning From Mechanical Ventilation in Care Unit, Dyspnea
- Trial name
- WEAN OBESE (NCT06867354)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Lung, Mechanical Ventilation Complication
Efficacy and Safety of Automated Closed-loop Ventilator vs Conventional Open-loop Ventilator in the Emergency Department
Patients presenting to the emergency department (ED) may require breathing support with machines depending on the condition. Throughout the breathing support, the settings on the breathing machines will be tailored to the…
- Conditions
- Ventilator Lung, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury, ARDS
- Trial name
- AVAC (NCT06157073)
- Testing
- Closed-loop ventilator, Open-loop ventilator
- Volunteers
- 132 people
- Sponsor
- University of Malaya
Wounds and Injuries, Ventilation Therapy; Complications
CT-based Model for Predicting Prolonged Weaning in Patients With Abdominal Trauma
Critically ill patients often require tracheal intubation for mechanical ventilation, and timely weaning is crucial for airway management and reducing complications.
- Trial name
- NCT06339073
- Testing
- mechanical ventilation
- Where
- China
- Volunteers
- 1,023 people
- Sponsor
- Jinling Hospital, China
Meconium Aspiration Syndrome
Use of Heliox in the Management of Neonates With Meconium Aspiration Syndrome
The aim of the study: to assess the effect of short-term mechanical ventilation with heliox in newborns with meconium aspiration syndrome on vital signs, oxygenation, acid-base balance and respiratory function parameters.
- Trial name
- NCT01274845
- Testing
- Heliox mechanical ventilation
- Where
- Poland
- Volunteers
- 8 people
- Sponsor
- Poznan University of Medical Sciences
Ventilation Therapy; Complications
Diaphragmatic Mobility In Ventilated Assisted Patients
The study was a randomized controlled trial. A total of 24 patients who met the inclusion criteria were included in this study and randomly divided by sealed envelope method into Experimental and Control groups with 12 patients…
- Trial name
- NCT04733261
- Testing
- Diaphragmatic mobility, Chest Physiotherapy
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd