Clinical trials: Mechanical Ventilation
Comparing Six Different Methods to Obtain Expiratory Time Constant
Expiratory Time Constant in Mechanically Ventilated Patients
Determining expiratory time constants in mechanically ventilated patients
- Trial name
- NCT05827640
- Testing
- data recording using conventional ventilation strategies (PCV and VCV)
- Where
- Slovakia
- Volunteers
- 30 people
- Sponsor
- East Slovak Institute for Cardiovascular Diseases
Severe Sepsis, Septic Shock
A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients.
To evaluate the use of sonographic inferior caval vein assessment in mechanically ventilated septic patients. Volume assessment in mechanically ventilated patients with inflammation is of major importance to guide fluid therapy.
- Trial name
- NCT00398736
- Testing
- sonographic measurement of inferior caval vein diameter
- Sponsor
- Charite University, Berlin, Germany
Respiration, Artificial
Ventilatory Weaning Guided by a New Index
Mechanical ventilation (MV) is an essential therapy for patients with acute respiratory failure. The ventilatory weaning process should be started when the precipitating causes of the use of the ventilatory prosthesis are…
- Trial name
- NCT04512677
- Testing
- Timed Inspiratory Effort (TIE index)
- Where
- 2 sites in Brazil
- Volunteers
- 144 people
- Sponsor
- Universidade Federal Fluminense
Intubated Requiring Sedation for Greater Than 48 Hours
AnaConDa Long Term Sedation Study
Heavy sedation or sleep is a common problem within the intensive care unit (ICU) using our standard intravenous medications. This commonly leads to confusion, low blood pressure, slow wake up and removal of the artificial…
- Trial name
- VALTS (NCT01983800)
- Testing
- Isoflurane, Propofol/midazolam
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Respiratory Distress Syndrome, Mechanical Ventilation Complication
Nebulized Furosemide, Heparin, Hypertonic Saline in Mechanically Ventilated Acute Respiratory Distress Syndrome Adult Patients
There are no specific drugs or therapies available to directly treat/prevent ARDS. Mechanical ventilation with an aim to minimize Ventilator Induced Lung Injury (VILI) and management of refractory hypoxemia are the keystones in…
- Trial name
- NCT07286409
- Testing
- nebulization
- Where
- Egypt
- Volunteers
- 344 people
- Sponsor
- Tanta University
Enteral Feeding, Ventilator-Associated Pneumonia
Impact of Intermittent and Continuous Enteral Feeding on Ventilator-associated Pneumonia in Pediatric ICUs
Mechanical ventilation has become one of the most important supportive treatment methods to save the life of critically ill children over time.
- Trial name
- NCT02973347
- Testing
- Intermittent enteral feeding, Continuous enteral feeding
- Volunteers
- 400 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Respiratory Failure, Diaphragm Injury
Diaphragm Ultrasound as a Powerful Tool in Managing Acute Hypoxemic Respiratory Failure in Hematological Patients
Acute hypoxemic respiratory failure due to parenchymal disfunction is one of the main complications of immunocompromised hematological patients.
- Conditions
- Respiratory Failure, Diaphragm Injury, Ultrasound, Mechanical Ventilation Complication
- Trial name
- NCT04026217
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Severe ARDS
Ultra-protective Ventilation Monitored by Electrical Impedance Tomography in Patients With Severe Acute Respiratory Distress Syndrome on Veno-venous ECMO
For ECMO supported patients with severe ARDS (acute respiratory distress syndrome), usual care include use of "ultraprotective" mechanical ventilation with tidal volume and pressure reductions that might ultimately enhance lung…
- Trial name
- EIT-ECMO (NCT05717218)
- Testing
- Ultra-protective mechanical ventilation monitored by electrical impedance tomography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Mechanical Low Back Pain
Effect of Deep Breathing on Balance in Patients With Chronic Mechanical Low Back Pain
The primary purpose of this study is to investigate the effects of deep breathing pattern on dynamic balance in patients with chronic mechanical low back pain versus healthy controls.
- Trial name
- NCT06398249
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October 6 University
Nonverbal Communication, Critical Illness
Vidatalk Communication Application: Usability, Acceptability and Efficacy Study
This Phase II Small Business Technology Transfer Research (STTR) will deliver a comprehensive patient communication solution for communication-impaired patients in the intensive care unit that may help decrease days in delirium…
- Trial name
- NCT02921776
- Testing
- Aim 1 - VidaTalk - post-extubation, Aim 2 - VidaTalk - intubated, Aim 3 - VidaTalk tablet app
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Ohio State University
Tongue Edema, Tongue Enlarged
Tongue Edema Caused by Intubation Tube in Intensive Care Unit Patients
Tongue edema (TE) is an enlargement of the tongue that can be noticed with the naked eye and protrudes from the mouth. Endotracheal intubation tube, which can exert high pressure on the tongue for a long time, may cause TE.
- Conditions
- Tongue Edema, Tongue Enlarged, Mechanical Ventilation Complication, Intubation Complication
- Trial name
- NCT05249738
- Testing
- Measuring tongue cross-sectional area by submental ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Selcuk University
Muscle Weakness, Critical Illness
Translation and Validation of the Intensive Care Unit Mobility Scale (IMS)
Intensive care unit acquired weakness (ICUAW) is a common issue in critically ill patients. Early mobilization can reduce the occurrence of ICUAW. This requires a standardized procedure based on validated scales.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication, Early Mobilization
- Trial name
- TAVIMS (NCT05591950)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Mechanical Ventilation Complication
Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation
Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical…
- Trial name
- NCT04448782
- Testing
- Asynchronies detection
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Corporacion Parc Tauli
Mechanical Ventilation With Oral Intubation, Weaning Invasive Mechanical Ventilation
Endotracheal Suctionning During Positive Pressure Extubation in ICU
The aim of this clinical trial is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU).
- Conditions
- Mechanical Ventilation With Oral Intubation, Weaning Invasive Mechanical Ventilation, Oxygen Saturation Measurement, Rox Index
- Trial name
- INTENTION (NCT07130123)
- Testing
- Suctionning extubation, No suctionning Extubation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Patient-Ventilator Interaction, Asynchrony, Patient-Ventilator
Standardising Terminology, Classification, Diagnostic Recognition and Reporting of Patient-ventilator Interactions: Protocol for an International Delphi Consensus Study
Patient-ventilator interaction describes how a mechanically ventilated patient's breathing effort aligns with ventilator support.
- Trial name
- INTERACT (NCT07638540)
- Testing
- Modified Delphi consensus survey
- Where
- Kuwait
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al Adan Hospital Kuwait
Pre-Term, Respiratory Disease
Closed-loop Oxygen Control in Ventilated Infants Born at or Near Term
Ventilated neonates frequently require supplementary oxygen to allow for adequate oxygen delivery to the tissues and normal cell metabolism.
- Trial name
- NCT05017727
- Testing
- Closed-loop automated oxygen control with Oxygenie Auto-O2 software (SLE6000)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- King's College Hospital NHS Trust
Guillain Barre Syndrome, Mechanical Ventilation
Early vs. Late Tracheostomy in Patients With Guillain -Barre Syndrome
Tracheostomy is one of the most common procedures in the intensive care unit in patients who need prolonged invasive mechanical ventilation.
- Trial name
- NCT06612242
- Testing
- early tracheostomy (less than 7 days from intubation), Late tracheostomy (more than 7 days from intubation)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Meir Medical Center
Respiratory Failure
Study to Improve Treatments and Follow-up of Children Who Need Respiratory Support
Mechanical ventilation is a vital therapeutic support, widely used in pediatric intensive care. Invasive ventilation (IV) is associated with risk of major complications ( nosocomial pneumonia, secondary pulmonary barotrauma…
- Trial name
- Edi-PTP (NCT02154542)
- Testing
- Neurovent Monitor XIII
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
- Trial name
- ELSE (NCT03281473)
- Testing
- Strategy 1, Strategy 2
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Ventilator-Induced Diaphragm Dysfunction
Pilot Study of TransAeris® System in Surgical Patients at Risk of Prolonged Mechanical Ventilation
This study will be conducted as a pilot trial of the TransAeris system for the prevention and treatment of ventilator-induced diaphragm dysfunction (VIDD) in patients identified prior to surgery to be at greater risk of prolonged…
- Trial name
- TRANSITION (NCT04309123)
- Testing
- TransAeris System
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Synapse Biomedical
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