Clinical trials: Maternal Morbidity
Maternal Morbidity and Mortality, Health Disparities
The Maternal Health Multilevel Intervention for Racial Equity (MIRACLE) Project
This community-partnered study will scale a community, provider, and system-level implementation intervention to reduce African American maternal morbidity and mortality disparities in two Michigan counties (Genesee and Kent).
- Trial name
- MIRACLE (NCT05386316)
- Testing
- Multilevel intervention for racial disparities in severe maternal morbidity and mortality, Standard Enhanced Prenatal Care (EPC) services
- Where
- United States
- Volunteers
- 540,000 people
- Sponsor
- Michigan State University
Postoperative Enfectious Morbidity, Postoperative GİS Functionally Recovery
The Effect of Saline Irrigation in the Peritoneal Cavity at Cesarean Delivery
The investigators hypotheised that irrigating the abdominal cavity with saline at the time of cesarean delivery will increase Gastrointestinal System Disfunction without maternal infectious morbidity(especially febril morbidity).
- Trial name
- NCT01716091
- Testing
- irrigation in the peritoneal cavity
- Where
- Turkey (Türkiye)
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Istanbul Bakirkoy Maternity and Children Diseases Hospital
Urgent Caesarian Section Secondary to Cord Prolapse
Complications: Urgent C Section VS Elective C Section
The medical literature does not provide sufficient information or recommendation regarding specific antibiotic coverage for urgent Caesarian sections.
- Trial name
- NCT01524107
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Hadassah Medical Organization
Cesarean Section
Labor Induction in Low-risk Nulliparous Women at 39 Weeks of Gestation to Reduce Cesarean: A Randomized Trial of Induction Versus Expectant Management in France (FRENCH-ARRIVE)
The recent ARRIVE trial conducted in United States of America in 2014-2017 demonstrates that elective induction of labor at 39 weeks for nulliparous women did result in a significantly lower frequency of cesarean delivery with no…
- Trial name
- FRENCH-ARRIVE (NCT04799912)
- Testing
- Elective labor induction
- Where
- France
- Volunteers
- 4,200 people
- Sponsor
- University Hospital, Bordeaux
Pregnancy Related
Trial of Community-based Patient Navigation
This study will test the effectiveness of a community-based patient navigator intervention from mid-pregnancy through 12 month postpartum for a high-risk population of medically underserved women.
- Trial name
- NCT05588245
- Testing
- Standard of Care, Community-based prenatal/perinatal/postpartum patient navigator
- Where
- United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Emory University
Maternal Complication of Pregnancy, Newborn Morbidity
Scaling up Evidence Based MNCH Interventions : A Quasi Experimental Study Umeed e Nau (UeN) Project
The Umeed-e-Nau (UeN) initiative aims to support the introduction, scale up, and further piloting of high quality and high impact interventions to improve Maternal, Newborn And Child Health (MNCH)in Pakistan by harnessing the…
- Conditions
- Maternal Complication of Pregnancy, Newborn Morbidity, Perinatal Problems
- Trial name
- UeN (NCT04184544)
- Testing
- Improving of quality of care at health facility and outreach level
- Where
- Pakistan
- Volunteers
- 5,000,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Cesarean Section, Surgical Site Infection
Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions
This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery.
- Conditions
- Cesarean Section, Surgical Site Infection, Wound Dehiscence, Seroma
- Trial name
- STRIP-CS (NCT07686913)
- Testing
- Steri-Strip™ Skin Closures, Standard Cesarean Wound Closure
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Riverside University Health System Medical Center
Maternal Morbidity and Mortality
Creating VIP Corps to Reduce Maternal Deaths
The goal of this observational study is to create and rigorously evaluate a violence intervention and prevention corps (VIP Corps) training using a randomized controlled trial among undergraduate and professional students; and to…
- Trial name
- NCT06089109
- Testing
- The Big 3, Implementation and Effectiveness of VIP Corps Training
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- Ann Coker
Sleep Apnea, Obesity
Sleep Apnea in Pregnancy Screening Study
Obstructive sleep apnea is known to be a significant source of morbidity in the general population. It has been proposed to be associated with the development of preeclampsia and fetal growth restriction.
- Trial name
- SAPSS (NCT01585844)
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Preeclampsia (PE)
Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)
The purpose of this study is to determine whether first-trimester screening for preeclampsia based on the FMF algorithm (a combination of maternal clinical, sonographic and biochemical parameters), improves maternal or perinatal…
- Trial name
- RANSPRE (NCT05521776)
- Testing
- First-trimester preeclampsia screening (FMF triple test)
- Where
- 22 sites in France
- Volunteers
- 14,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion
Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury Biomarkers
The AMNIO-BRAIN Trial is a research study looking at whether a simple treatment during labor can help protect a baby's brain. Some newborns develop a condition called hypoxic-ischemic encephalopathy (HIE), which happens when the…
- Conditions
- Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion, Neonatal Brain Injury
- Trial name
- AMNIO-BRAIN (NCT07610642)
- Testing
- Intrauterine Pressure Catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
¨Maternal Morbidity¨, ¨Perinatal Mortality¨
A Study to Measure the Effectiveness of an Intervention Package Aiming to Decrease Perinatal Mortality and Increase Institution-based Obstetric Care Among Indigenous Populations in Guatemala
A matched pair cluster-randomized trial of this intervention package will be conducted in four rural and indigenous districts (Huehuetenango, Quiche, Alta Verapaz and San Marcos) of the Republic of Guatemala, using the health…
- Trial name
- NCT01653626
- Testing
- package of 3 interventions
- Where
- Guatemala
- Volunteers
- 1 people
- Sponsor
- Hospital San Juan de Dios Guatemala
Postpartum Hemorrhage, Postpartum Depression
Postpartum Video Education in High Risk Populations
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Depression, Postpartum Sepsis, Postpartum Preeclampsia
- Trial name
- NCT06310720
- Testing
- Video Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Maternal Sepsis, Infections
EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis (Aim 1)
Sepsis is the second leading cause of maternal death in the U.S. Labor and postpartum are particularly vulnerable risk periods. The goal of this multi-center, multidisciplinary study is to evaluate a maternal sepsis safety bundle.
- Trial name
- NCT06145724
- Testing
- Maternal Sepsis Safety Bundle
- Where
- 4 sites in United States
- Volunteers
- 33,183 people, healthy volunteers welcome
- Sponsor
- Columbia University
Placenta Accreta / Percreta
Clinical Situations at High Risk of Placenta Accreta / Percreta
The purpose of this study is to identify what factors -either individual or related to the type of management received- influence the maternal outcomes in pregnant women at high risk for placenta accreta i.e , women with placenta…
- Trial name
- Paccreta (NCT02010229)
- Where
- France
- Volunteers
- 674 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy Related Complications
PRONTO: Obstetric and Neonatal Emergency Training Program: A Cluster-Randomized Trial to Measure Impact
Rates and causes of maternal mortality in Mexico have dropped only slightly; thus, reaching the internationally established Millennium Development Milestones (MDM) is still a distant goal.
- Trial name
- PRONTO (NCT01477554)
- Testing
- PRONTO training
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico