Clinical trials: Massive Hemorrhage
Blood Loss Massive, Trauma
Evaluation of the Clinical Performance of the Quantra System With the QStat Cartridge
This pilot study will evaluate the performance of the Quantra System comprised of the Quantra Hemostasis Analyzer with the QStat Cartridge in trauma patients or patients with OB hemorrhage.
- Conditions
- Blood Loss Massive, Trauma, Hemorrhage, Postpartum
- Trial name
- NCT03912545
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Massive Blood Transfusion in Trauma Patients
Comparing TASH Score and Modified TBSS in Trauma Patients in Need for Massive Blood Transfusion
Evaluate And Compare predictive value of TASH Score And MTBBS In need for Massive Blood Transfusion
- Trial name
- NCT06128057
- Testing
- Blood products
- Volunteers
- 140 people
- Sponsor
- Assiut University
Trauma
Unmet Need for Massive Transfusion in Indian Trauma Patients
This study aims to estimate the difference between predicted and provided massive transfusion in adult trauma patients admitted to university hospitals in urban India.
- Trial name
- NCT03068104
- Testing
- No intervention
- Volunteers
- 16,047 people
- Sponsor
- Karolinska Institutet
Pulmonary Hemorrhage
A Novel Method of Lung Isolation Compared With Standard Methods in a Model of Massive Pulmonary Hemorrhage
Dr. Purdy has developed a novel bronchial blocker device that has multiple applications. In this project, a simulation model of massive pulmonary hemorrhage in an adolescent intubating manikin will be used to compare the novel…
- Trial name
- BloodyBlocker (NCT05001607)
- Testing
- Bronchial Blocker
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Wounds and Injuries, Shock, Hemorrhagic
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and…
- Trial name
- TROOP (NCT05638581)
- Testing
- LTOWB, Components
- Where
- 13 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of Alabama at Birmingham
Placenta Accreta, Post Partum Hemorrhage
Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
Monocentric prospective observational study comparing the use of tourniquet in low uterus segement versus standard procedure in hysterectomy owing to placenta accreta
- Conditions
- Placenta Accreta, Post Partum Hemorrhage, Blood Loss Massive
- Trial name
- NCT03707132
- Testing
- Tourniquet: Folley catheter in the low segment of the uterus
- Volunteers
- 43 people
- Sponsor
- University Tunis El Manar
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Massive Transfusion, Hemorrhage
Evaluating of the Hospital Universitario de Canarias Massive Transfusion Protocol
Massive haemorrhage is defined as the necessity of 3 or more packed red blood cells in one hour, the transfusion of 10 packed blood cells, the loss of the half of the blood volume, the loss of 4-5 cc/kg/h or more, and haemorrhage…
- Trial name
- PHM (NCT03074890)
- Testing
- Application Protocol
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario de Canarias
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Massive Hemorrhage, Massive Blood Loss
Recombinant Activated Factor VII in the Management of Massive Bleeding in Hospital Universiti Sains Malaysia
This is a retrospective descriptive study, to study the treatment indications, changes in transfusion need, coagulation profiles changes and clinical outcome (survival, complication) of non-haemophiliac patients who received…
- Conditions
- Massive Hemorrhage, Massive Blood Loss, Massive Blood Transfusion; Thrombocytopenia
- Trial name
- NCT03251547
- Testing
- NovoSeven
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Universiti Sains Malaysia
Multiple Trauma, Massive Bleeding
Evaluation of the TICCS Capacity to Identify Trauma Patients With Acute Coagulopathy and Massive Bleeding
A prospective single-centre non-comparative non-interventional open study has been designed to validate, in a target number of 100 trauma patients, the correlation between TICCS evaluated on the site of injury and…
- Conditions
- Multiple Trauma, Massive Bleeding, Early Complication of Trauma
- Trial name
- NCT02132208
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Régional de la Citadelle
Postpartum Hemorrhage, Uterine Atony
Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage
The objective of the study is to demonstrate whether cooling the uterine smooth muscle during cesarean section (following delivery of the fetus) will promote better uterine contraction and involution resulting in lower blood…
- Trial name
- NCT02229513
- Testing
- Uterine Cooling
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Massive Blood Loss, Hypothermia
Study to Actively Warm Trauma Patients
This study evaluates the feasibility of using thermal blankets to actively warm massively bleeding trauma patients at Sunnybrook Health Sciences Centre.
- Trial name
- NCT04399902
- Testing
- Thermal Blanket
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hemorrhagic Shock, Trauma Coagulopathy
The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study)
Background: Bleeding and coagulopathy still accounts for the majority of early in-hospital deaths following trauma. There have been lately several published studies suggesting that higher transfusion ratios of fresh frozen plasma…
- Trial name
- TRFL (NCT00945542)
- Testing
- Massive transfusion protocol, Standard of care
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ruptured Abdominal Aortic Aneurism
START - Early Thrombocyte Administration to Patients With Ruptured Abdominal Aortic Aneurism
The purpose of this study is to investigate the effect of platelet infusion prior to transfer to a vascular surgical department in patients with a ruptured abdominal aortic aneurism.
- Trial name
- rAAA (NCT01291290)
- Testing
- Platelet
- Where
- Denmark
- Volunteers
- 420 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Placenta Previa, Placenta Accreta
ROTEM in Patients With Placenta Previa
The rotational thromboelastogram (ROTEM) test can be performed on patients with placenta previa/accreta/increta/percreta who have a high likelihood of massive bleeding, and the predictors can be identified by comparing the…
- Conditions
- Placenta Previa, Placenta Accreta, Placenta Increta, Placenta Percreta
- Trial name
- NCT04213755
- Testing
- ROTEM
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital