Clinical trials: Marfan Syndrome
Marfan Syndrome, Aortic Dissection
Nutritional Ketosis Marfan
In this pilot clinical trial, the investigators will test whether a carefully supervised ketogenic diet can safely help people with Marfan syndrome who already have a chronic or residual aortic dissection.
- Trial name
- NCT07495267
- Testing
- Ketogenic diet
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Marfan Syndrome, Ectopia Lentis
Classifying Ectopia Lentis in Marfan Syndrome Into Five Grades of Increasing Severity
Marfan syndrome is characterized by musculoskeletal manifestations, cardiovascular disease and ocular abnormalities, particularly ectopia lentis.
- Trial name
- NCT04319107
- Testing
- ophthalmological examinations using a slit lamp bio microscopy and a three-mirror lens, standard procedure.
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Periodontitis, Periodontal Health
Asprosin Level in Individuals With Periodontal Disease
The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis…
- Conditions
- Periodontitis, Periodontal Health, Gingivitis
- Trial name
- ALIGCF (NCT06627972)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Marfan Syndrome
Losartan Versus Atenolol for the Treatment of Marfan Syndrome
Marfan syndrome is a genetic disease of our connective tissue, which provides material and support for our skeleton, muscles, blood vessels and other parts of our bodies.
- Trial name
- NCT00593710
- Testing
- Losartan, Atenolol
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of British Columbia
Sepsis, Septicemia
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
We propose to develop novel diagnostic tests for severe sepsis and community acquired pneumonia (CAP). This program, entitled Community Acquired Pneumonia \& Sepsis Outcome Diagnostics (CAPSOD), is a multidisciplinary…
- Conditions
- Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic
- Trial name
- NCT00258869
- Where
- 3 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- National Center for Genome Resources
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Superficial Cyst or Mass and Sinus on and Around the Ear
The Superficial Lesions in the Peri-auricular Region
Superficial lesions on and around the ear are uncommon with many differential diagnoses and different characteristic histopathologic features.
- Trial name
- NCT04497337
- Testing
- Complete excision to superficial lesions around the ear
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mohammed Elrabie Ahmed
Marfan Syndrome
Randomized, Double-blind Study for the Evaluation of the Effect of Losartan Versus Placebo on Aortic Root Dilatation in Patients With Marfan Syndrome Under Treatment With Beta-blockers
To study the effect of losartan (an angiotensin receptor blocker-ARB) on aortic root growth in patients with Marfan syndrome, already treated with beta-blockers (BB). The effect of losartan will be compared to placebo.
- Trial name
- NCT00782327
- Testing
- Losartan
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Hospital, Ghent
Aphakia
Artisan Aphakia Lens for the Correction of Aphakia in Children
The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children.
- Trial name
- NCT01547442
- Testing
- Artisan Aphakia Intraocular Lens
- Where
- 19 sites in United States, Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ophtec USA
Acne Vulgaris
Assessment of Serum Asprosin Level in Male Patients With Acne Vulgaris
Subject of interest is to evaluate serum level of asprosin in male patients with acne vulgaris, demonstrate the relation between acne vulgaris severity and level of asprosin in these patients \& the relation between metabolic…
- Trial name
- NCT05471388
- Testing
- serum asprosin
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sohag University
Stable Angina Pectoris, Periodontitis
Effect of Periodontal Therapy on Asprosin in Stable Angina
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis.
- Trial name
- NCT07591844
- Testing
- Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Bariatric Sleeve Gastrectomy
Impact of Asprosin and Neuregulin 4 on Metabolic Parameters, Anthropometric Indices and Body Composition After Laparoscopic Sleeve Gastrectomy
Asprosin and neuregulin 4 (NRG4) sit on opposing arms of adipose endocrine physiology. Asprosin is a fasting-induced, white adipose-derived glucogenic and orexigenic hormone that rises with adiposity and insulin resistance.
- Trial name
- NCT07806448
- Testing
- sleeve gastrectomy
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Sleep-disordered Breathing, Snoring
Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome
Upper airway obstruction (UAO) is an unrecognized source of hemodynamic stress that may contribute to aortic adverse events in persons with Marfan Syndrome (MFS).
- Trial name
- MSB (NCT03985657)
- Testing
- CPAP
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Marfan Syndrome
Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Marfan Syndrome
This research study aims to evaluate the effect of a 6-month adapted physical activity program (APA) on the endurance capacities (evaluated as the maximum oxygen consumption [VO2 peak] on a cardiopulmonary exercise test) of…
- Trial name
- M&M's (NCT05838235)
- Testing
- Adapted Physical Activity program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Rheumatoid Arthritis, Metabolic Syndrome
Serum Asprosin, Metabolic Syndrome, and Cardiometabolic Risk in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with a significantly increased risk of cardiovascular disease and metabolic syndrome (MetS).
- Conditions
- Rheumatoid Arthritis, Metabolic Syndrome, Cardiovascular Diseases
- Trial name
- NCT07793747
- Volunteers
- 75 people
- Sponsor
- Assiut University
Diabetes Mellitus
Glucose-dependent Asprosin Dynamics
The study entitled " Asprosin Dynamics relating to serum Glucose levels under controlled alterations" investigates the dynamics of Asprosin in relation to glucose levels under controlled conditions in diabetic patients.
- Trial name
- NCT03358121
- Testing
- Clamp study
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Heidelberg University
Pancreatic Cyst, Pancreatic Neoplasms
Clinical Evaluation Of Needle-based Confocal Laser Endomicroscopy in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas
This study focuses on three different lesions: pancreatic cysts, lymph nodes near the gastrointestinal tract and pancreatic masses.
- Conditions
- Pancreatic Cyst, Pancreatic Neoplasms, Pancreatic Adenoma, Pancreatic Cancer
- Trial name
- CONTACT (NCT01563133)
- Testing
- EUS-FNA, nCLE
- Where
- 3 sites in France
- Volunteers
- 330 people
- Sponsor
- Mauna Kea Technologies
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Renal Fibrosis, CKD
Molecular Mechanisms of Fibrillin/LTBP Superfamily in Renal Fibrosis and Cardiorenal Syndrome
This project is to understand the LTBP4 expression in human renal fibrotic tissues. The investigators will exam major location of LTBP4 expression and check any similar or discrepancy in renal fibrosis with different etiologies.
- Trial name
- NCT05012228
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Marfan Syndrome, Loeys-Dietz Syndrome
Genotypes and Craniofacial Phenotypes in Orthodontic Patients With Marfan and Loeys-Dietz Syndromes
The aim of this retrospective observational study is to investigate the association between genotype and craniofacial phenotype in orthodontic patients affected by Marfan and Loeys-Dietz syndromes.
- Trial name
- NCT07360704
- Testing
- Cephalometric analysis
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Andrea Scribante