Clinical trials: Manic Depression
Bipolar I Disorder
A Multicenter, Placebo-controlled, Double-blind Investigative Extension Trial of the Safety and Efficacy of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode
To investigate the safety and efficacy of long-term administration of aripiprazole by performing extended administration of the treatment administered in the preceding multicenter, double-blind, placebo-controlled, parallel…
- Trial name
- NCT00606177
- Testing
- Aripiprazole
- Where
- 12 sites in China, Japan and 2 more
- Volunteers
- 99 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Common Mental Disorder
Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders
To explore the whole-brain anatomical and functional abnormalities in drug-naive patients with schizophrenia ,drug-naive patients with BD, drug-naive patients with MDD and healthy controls by using a combination of…
- Trial name
- NCT04218981
- Testing
- Antipsychotic drugs, Mood stabilizer, Paroxetine
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central South University
Bipolar Disorder
Transcranial Photobiomodulation for Executive Function in Bipolar Disorder
Transcranial light therapy, or transcranial photobiomodulation (tPBM), is a treatment that stimulates the brain by applying near-infrared light to the forehead.
- Trial name
- TPEB (NCT05408637)
- Testing
- Transcranial Phoobiomodulation (tPBM)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Paolo Cassano
Schizophrenia, Schizoaffective Disorder
A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder
Varenicline (Chantix) is a smoking cessation treatment that was approved in 2006 by the FDA for treatment of nicotine dependence and may be particularly beneficial in smokers with schizophrenia or bipolar disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Smoking
- Trial name
- SCRP (NCT00621777)
- Testing
- Varenicline
- Where
- 10 sites in United States
- Volunteers
- 247 people
- Sponsor
- Massachusetts General Hospital
Bipolar I Disorder, Schizoaffective Disorder
Open Label Extension Study of NCT06221852
This is a 12-week open-label extension study for participants completing study NCT06221852.
- Conditions
- Bipolar I Disorder, Schizoaffective Disorder, Psychosis
- Trial name
- NCT06558201
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Bipolar Disorder
Taking Action for College Students
The goal of this research is to investigate whether a peer-delivered illness self-management program called Taking Action can help college students with serious mental illnesses.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT06700902
- Testing
- Taking Action
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Temple University
Bipolar Disorders
Bipolar Disorder With Alcoholism in Han Chinese
The aim of this study is to explore relation between the comorbidity of different bipolar disorders with alcoholism and neuropsychiatric function and candidate genes.
- Trial name
- NCT01188395
- Where
- Taiwan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Schizoaffective Disorder, Schizophrenia
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
Testing an mHealth mobile interventionist texting program on illness management.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT03062267
- Testing
- Mobile Interventionist
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Washington
Schizophrenia, Bipolar Disorder
Impact of Genetic Counseling for Individuals With Mental Illness
People who have experienced mental illnesses like schizophrenia, bipolar disorder or schizoaffective disorder often have a poor understanding of the causes of their illness, and that they are often very worried about how the…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT00713804
- Testing
- Genetic Counseling, Educational Booklet
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia
Bipolar Disorder, Depression
Disseminating Evidence-based Mood Disorder Chronic Care Models
This study will determine if a version of the chronic care model for individuals with mood disorders can improve patient health.
- Trial name
- NCT01615458
- Testing
- Chronic Care Model for Mood Disorders
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Severe Mental Illness, Depression / Major Depressive Disorder
Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)
This randomized, rater-blind, multicenter clinical trial will evaluate whether a personalized pharmaco-lifestyle intervention improves mental functioning in adults with severe mental illness, including schizophrenia, bipolar…
- Conditions
- Severe Mental Illness, Depression / Major Depressive Disorder, Bipolar Disorder (BD), Schizophrenia
- Trial name
- LIFETRAIN (NCT07586150)
- Testing
- Semaglutide (SEMA), Exercise module, Anti-inflammatory diet module
- Where
- 5 sites in Austria, Germany and 1 more
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Bipolar Disorder
Trial of Olanzapine in Patients With Manic or Mixed Episode of Bipolar I Disorder
The purpose of this study is to confirm the efficacy of olanzapine in the treatment of manic or mixed symptoms associated with bipolar I disorder.
- Trial name
- NCT00129220
- Testing
- olanzapine, haloperidol
- Where
- 16 sites in Japan
- Volunteers
- 224 people
- Sponsor
- Eli Lilly and Company
Anxiety Disorder, Mood Disorder
New Drugs in the Treatment of Mood Disorders
This clinical study compares the effectiveness of two anticonvulsants Lamotrigine (Lamictal) Monotherapy and Gabapentin (Neurontin) in patients with treatment resistant affective disorders.
- Conditions
- Anxiety Disorder, Mood Disorder, Psychotic Disorder
- Trial name
- NCT00001482
- Testing
- Lamotrigine (Lamictal® (Registered Trademark), Gabapentin (Neurontin® (Registered Trademark))
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder
Olanzapine Versus Lithium in the Treatment of Acute Depression in Patients With Bipolar II or Bipolar Not Otherwise Specified(OL Study)
Determine the efficacy and tolerability of olanzapine for treatment of acute depression in patients with bipolar II or bipolar disorder NOS compared with lithium.
- Trial name
- NCT02287259
- Testing
- olanzapine, lithium
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Tadashi Hasegawa
Bipolar Affective Disorder
rTMS in the Treatment of Bipolar Depression
Bipolar affective disorder (BPAD) is: A serious mental illness Estimated to be present in as high as 6.4% of the population in Western populations Associated with considerable disability and high morbidity.
- Trial name
- NCT00436020
- Testing
- TMS
- Where
- Australia
- Volunteers
- 51 people
- Sponsor
- Bayside Health
Depression, Bipolar
Olanzapine Treatment of Patients With Bipolar I Disorder
The purpose of this study is to assess whether olanzapine is superior to placebo in patients with bipolar depression.
- Trial name
- NCT00510146
- Testing
- Olanzapine
- Where
- 16 sites in China, Japan and 1 more
- Volunteers
- 514 people
- Sponsor
- Eli Lilly and Company
Schizophrenia, Schizoaffective
Exercise-based Program for Rehabilitation of Veterans With Severe Mental Illness
This is a hybrid1, effectiveness-implementation study of yoga-based exercises (YE) as an adjunctive tool for rehabilitation among persons with Severe Mental Illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective, Bipolar Disorder 1
- Trial name
- ESHANTI (NCT05157620)
- Testing
- Yoga-based Exercise (YE), Wellness Lifestyle Program (WLP)
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Bipolar I Disorder
Digital Phenotypes for Predicting Depression_Validation
This 12-month, single-site prospective observational study will prospectively monitor the recurrence of mood episodes while continuously collecting passive digital phenotypes in individuals with and without mood disorders.
- Conditions
- Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Mood Disorders
- Trial name
- NCT07880015
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Schizophrenia, Bipolar Disorder
A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children
The purpose of this study is to evaluate the effects of risperidone compared with other atypical antipsychotic drugs on the physical maturity, growth and development of children, and the risk of prolactin-related adverse events…
- Conditions
- Schizophrenia, Bipolar Disorder, Autistic Disorder, Conduct and Other Disruptive Behavior Disorders
- Trial name
- NCT01050582
- Testing
- Risperidone, Other atypical antipsychotic drugs
- Where
- 28 sites in United States, Belgium and 4 more
- Volunteers
- 244 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Bipolar Disorders, Schizophrenia
Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)
The primary aim of this study is to determine the feasibility of long-acting injectable naltrexone administration in a clinical trial in patients with SMI who also have a diagnosis of alcohol dependence.
- Conditions
- Bipolar Disorders, Schizophrenia, Schizoaffective Disorders, Alcohol Dependence
- Trial name
- vivitrol (NCT00453804)
- Testing
- injectable naltrexone, oral naltrexone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- State University of New York - Upstate Medical University