Clinical trials: Management
Hypersensitivity Dentin, Fluoride Varnishes
Effect of Fluoride Varnish Formulation on the Management of Dentin Hypersensitivity
This randomized controlled clinical trial aims to determine whether different fluoride varnish formulations reduce dentin hypersensitivity (DH) in young adults diagnosed with DH.
- Trial name
- NCT07286344
- Testing
- Aqueous fluoride varnish, 9,500 ppm NaF, Resin/rosin-based varnish, 22,600 ppm NaF
- Where
- Chile
- Volunteers
- 92 people
- Sponsor
- University of Concepcion, Chile
Premature Infants, Very Premature Infants
Anakinra Pilot 2 - A Study to Optimise Dose and Route of Administration of Anakinra in Preterm Infants
A phase 2 randomised, three-arm, parallel-group, dose-ranging trial to determine safety, efficacy and optimal dosing of intravenous anakinra in premature neonates, with subcutaneous pharmacokinetic sub-study.
- Conditions
- Premature Infants, Very Premature Infants, Inflammation
- Trial name
- AP2 (NCT07254000)
- Testing
- Anakinra (Kineret®)
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 24 people
- Sponsor
- Monash Medical Centre
Multimoda Lultasound, Thyroid Cancer
Multimodality US Based on Angio Planewave Ultrasensitive Imaging and Shear Wave Elastography to Evaluate the Malignancy Risk Value of Thyroid Nodules
The goal of this clinical trial is to explore the value of a multimodal ultrasound model based on Angio Planewave Ultrasensitive Imaging, Shear Wave Elastography and grayscale ultrasound in the differential diagnosis of benign…
- Conditions
- Multimoda Lultasound, Thyroid Cancer, Microvascular Classification
- Trial name
- NCT06530771
- Testing
- ultrasound
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Figure Out the Best Method of Fixation for Management of Patients With Diabetic Fracture Ankle
Management of Fracture Ankle in Adults With Uncontrolled Diabetes by Hind Foot Nail With Versus Without Joint Preparation , in Assiut University Hospital
Diabetes is a well-known risk factor for complications following ankle fracture fixation.Current recommendations for operative treatment of ankle fractures in patients with diabetes consist of increased rigid fixation and…
- Trial name
- NCT05039957
- Testing
- joint preparation, without joint preparation
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Assiut University
Intestinal Obstruction Fluid Management With Hypertonic Saline
Comparison Between Two Concentration of Hypertonic Saline in Intestinal Obstruction Surgery
Background and Rationale : Perioperative fluid management is a challenging issue in surgical care especially in a procedure specific model.
- Trial name
- NCT03741257
- Testing
- Hypertonic saline
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Management of Moderate to Severe Pain
Pharmacokinetics Study of ALO-02 and OxyContin
To characterize the single- and multiple-dose pharmacokinetics of oxycodone following the administration of ALO-02 40 Mg Twice Daily, ALO-02 80 Mg Once Daily or Oxycontin 40 Mg Twice Daily in Healthy Volunteers
- Trial name
- NCT01557257
- Testing
- ALO-02, Naltrexone block, OxyContin
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Pfizer
Mesenchymal Stem Cell Transplantation
Intraosseous Administration of Mesenchymal Stromal Cells for Patients With Graft Failure After Allo-HSCT
Multipotent mesenchymal stromal cells (MSCs) participate in the formation of bone marrow niches for hematopoietic stem cells. Donor MSCs can serve as a source of recovery for niches in patients with graft failure (GF) after…
- Trial name
- NCT03389919
- Testing
- MSC administration (intraosseal)
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- National Research Center for Hematology, Russia
HIV Infections
HIV Symptom Management Program for African American Mothers
African American mothers infected with HIV face unique challenges in management of their disease. The goal of this study was to determine the effectiveness of an HIV self-care and symptom management program designed to help…
- Trial name
- NCT00065819
- Testing
- HIV Symptom Education Program
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pain, Postoperative
Selective Block of the Axillary Nerve in Postoperative Pain Management
In this study the investigators wish to compare the effect of a selective axillary nerve block to placebo in patients undergoing arthroscopic shoulder surgery.
- Trial name
- NCT01463865
- Testing
- ropivacaine, Sodium chloride
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hillerod Hospital, Denmark
Atrial Fibrillation
Accuracy of Rhythm Detection by a Wearable Smart Watch for Cardiac Arrhythmias (The WATCH-RHYTHM Study)
It is an attempt to see the reliability of the Wearable Smart Watch in identifying atrial fibrillation and other arrhythmias compared to the data detected from ILRs.
- Trial name
- NCT04499807
- Testing
- AFib detection with wearable smart watch
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Lung Cancer, Radiation Toxicity
Flaxseed Supplement in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Undergoing Chemotherapy and Radiation Therapy
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Flaxseed may help protect normal cells from the side effects of radiation therapy.
- Trial name
- NCT00955942
- Testing
- flaxseed
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Colorectal Cancer
Pharmacodynamic Evaluation of Stool Output Following Oral Administration of Various Low Volume PEG3350-based Gut Cleansing Solutions Using the Split Dose Intake in Healthy Subjects
This study is to investigate the effect of various modified low volume polyethylene glycol (PEG) 3350 and ascorbic acid/ascorbate (PEG+ASC)-based gut cleansing solutions on stool output in healthy subjects.
- Trial name
- OUT (NCT01834742)
- Testing
- NER1006, Moviprep
- Where
- 2 sites in Romania
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Norgine
Heart Failure
Disease Management Platform for Heart Failure (DMP-HF)
AMAZE™ is a disease management platform (DMP) designed to educate patients about heart failure, help engage them in healthy behaviors and assist them in taking their medications as prescribed.
- Trial name
- DMP-HF (NCT04782973)
- Testing
- AMAZE (TM) Disease Management Platform
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Contrast Nephropathy
Renal Insufficiency Following Contrast Media Administration Trial III
The urine flow rate (UFR)-guided and the left-ventricular end-diastolic pressure (LVEDP)-guided hydration regimens have been proposed to prevent contrast-induced acute kidney injury (CI-AKI).
- Trial name
- REMEDIALIII (NCT02489669)
- Testing
- RenalGuard system™® (PLC Medical Systems, Inc. Franklin, MA, USA)
- Volunteers
- 700 people
- Sponsor
- Clinica Mediterranea
Latent Phase Labour
Early Labour Assessment and Support at Home
To determine, among healthy first time mothers who are uncertain as to when to come to hospital in labour, if home visits by obstetrical nurses compared to telephone advice have an impact on reducing cesarean section rate.
- Trial name
- NCT00225329
- Testing
- Labour assessment and support
- Volunteers
- 1,466 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Children Requiring IV Placement
Robot-Based Distraction to Reduce Pain and Distress in the Pediatric Emergency Department
Intravenous (IV) insertion is one of the most common procedures for children seeking medical treatment in the Emergency Department (ED). This procedure is often painful and distressing for children and families.
- Trial name
- NCT02997631
- Testing
- MEDi Robot
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- University of Alberta
Healthy
Clinical Trial to Compare the Pharmacokinetics of TAH Tablet in Comparison to the Co-administration of Telmisartan, Amlodipine and Hydrochlorothiazide in Healthy Male Volunteers
randomized, open-label, single dose, replicate crossover clinical trial to compare the pharmacokinetics of TAH tablet in comparison to the co-administration of telmisartan, amlodipine and hydrochlorothiazide in healthy male…
- Trial name
- NCT02739672
- Testing
- TAH Tablet (Telmisartan/Amlodipine besylate/Hydrochlorothiazide), TWYNSTA(Telmisartan+Amlodipine besylate), Hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IlDong Pharmaceutical Co Ltd
Oxygen Deficiency, COPD Exacerbation
FreeDom: Innovative Strategy for the Management of COPD Exacerbations
The main objective of the study is to assess the "FreeDom" innovative strategy (FreeO2 at Domicile) to reduce hospitalization duration in patients with COPD exacerbation.
- Trial name
- NCT03396172
- Testing
- Control, FreeDom
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Appendiceal Abscess
Study of Management of Appendicular Abscess
This study aims to detect indications of surgical drainage after failure Ultrasound guided percutaneous drainage This study will include any male and female above 18 years old that presented with appendicular abscess Patients…
- Trial name
- NCT06718595
- Volunteers
- 100 people
- Sponsor
- Assiut University
Bacterial Infections
Use of Low-cost Molecular Diagnostic Techniques as a New Surveillance Model for Diseases Preventable by Vaccinations.
Vaccine-preventable disease (VPD) surveillance should be a priority throughout the world. In Italy, however, there is limited attention to the epidemiology of VPDs, with the consequence that their incidence is largely…
- Trial name
- NCT06322277
- Testing
- Analysis of biological sample
- Where
- 4 sites in Italy
- Volunteers
- 1 people
- Sponsor
- Meyer Children's Hospital IRCCS