Clinical trials: Management
NASH
Drug-drug Interaction Study Between EDP-305, Midazolam, Caffeine and Rosuvastatin in Healthy Volunteers.
A non-randomized, multiple-dose, open-label, single sequence study to evaluate effect of concomitant administration of EDP-305 on the pharmacokinetics and safety of midazolam, caffeine, and rosuvastatin in healthy human…
- Trial name
- NCT03187496
- Testing
- Midazolam, Caffeine, Rosuvastatin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Prehypertension
A Clinical Trial of an Herbal Liquid Supplement - 'DBPS' for Managing Blood Pressure
Prehypertension is a clinical condition characterized by systolic blood pressure (SBP) readings between 120 and 139 mmHg and/or diastolic blood pressure (DBP) readings between 80 and 89 mmHg, as per the Joint National Committee…
- Trial name
- NCT07629570
- Testing
- DBPS
- Where
- 4 sites in India
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Eetho Brands, Inc
Post Partum Haemorrhage
Intramuscular Oxytocics: A Randomised Control Trial
A quarter of all pregnancy and child-birth related deaths are due to excessive bleeding after the birth, "post-partum haemorrhage" (PPH). In the UK, PPH affects approx 10% of new mothers.
- Trial name
- IMox (NCT02216383)
- Testing
- Carbetocin, Syntocinon, Syntometrine
- Where
- 5 sites in United Kingdom
- Volunteers
- 5,798 people, healthy volunteers welcome
- Sponsor
- North Bristol NHS Trust
Administration Methods of Labor Analgesia
Epidural Loading Prior to Catheter Insertion
This study explores the potential for a more rapid onset of pain relief when drug administration is performed through the epidural needle, a technique of epidural loading that provides a rapid and reliable level of labor…
- Trial name
- NCT02883283
- Testing
- Epidural loading dose, Epidural catheter, Epidural needle
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Obesity
Probiotic for Weight Management in Overweight and Obese Adults
To evaluate the impact of pasteurized Akkermansia muciniphila Akk11 capsules versus placebo on body composition (including body weight, BMI, body fat percentage, waist-to-hip ratio, wrist circumference, visceral fat area, and…
- Trial name
- NCT07507929
- Testing
- Probiotic
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Counselling
The Effects of the Breastfeeding Problems Management Model on Breastfeeding Problems, Motivation and Success
This randomized controlled interventional study was conducted with 50 women (25 intervention and 25 control). While the intervention group received an eight-week postpartum education and care according to the Breastfeeding…
- Trial name
- NCT05543902
- Testing
- Breastfeeding Problems Management Model (BPMM)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Essential Hypertension, Type 2 Diabetes
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1019" and Co-administration of "BR1019-3" and "BR1019-2" in Healthy Volunteers
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of "BR1019" and co-administration of "BR1019-3" and "BR1019-2" in healthy volunteers
- Trial name
- NCT06636877
- Testing
- BR1019, BR1019-2, BR1019-3
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Pain, Anxiety
Music and Local Anesthesia During Dermatologic Procedures
The goal of the study is to determine the effect of classical music on participants pain and anxiety associated with lidocaine administration during routine standard of care dermatologic procedures.
- Trial name
- NCT04317170
- Testing
- Music
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Recurrent Pregnancy Loss
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL
compare uterine artery blood flow before and after the administration of Isosorbide mononitrate as a nitric oxide donor during mid secretory phase of menstrual cycle for patients with unexplained recurrent pregnancy loss.
- Trial name
- NCT05341856
- Testing
- isosorbide mononitrate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Acute Endophthalmitis Post-operative
Targeted PCR and Acute Endophthalmitis
Endophthalmitis is a serious eye infection of exogenous origin (post-operational, post-traumatic) or endogenous origin (metastatic). This is a diagnostic and therapeutic emergency.
- Trial name
- Targeted PCR (NCT02850653)
- Testing
- PCR : 16S ribosomal DNA and real-time targeted PCR, Sampling of aqueous humour
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy Female
A Study of Milvexian in Healthy Adult Females
The purpose of this study is to measure the effect of milvexian given for approximately 2 weeks on (a) how the liver metabolizes other drugs (in this case one called midazolam), and (b) the pharmacokinetics (the way the body…
- Trial name
- NCT05706753
- Testing
- Milvexian, Midazolam, Ethinylestradiol
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Healthy Volunteers
Measure Exposure Of Tanezumab In Healthy Volunteers When Administering The Drug Subcutaneously
The hypothesis of this study is that subcutaneous administration of tanezumab results in lower drug exposure compared to intravenous administration of tanezumab.
- Trial name
- NCT00788294
- Testing
- tanezumab
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Pfizer
Insomnia
Follow-up of a Study Examining Sleep Management in United States Veterans
The first part of the pilot study, as detailed in Unique Protocol ID No. 27522, is a randomized clinical trial that compares the effects of a mind-body bridging program with a sleep hygiene program to improve sleep quality in…
- Trial name
- NCT00935337
- Testing
- Mind-Body Bridging Program, Sleep Hygiene
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Utah
Hypoxic Ischemic Encephalopathy
Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels)
Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication due to systemic asphyxia which occurs in about 20 of 1,000 full-term infants and nearly 60% of premature newborns.
- Trial name
- NCT02349672
- Testing
- blood sample
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Injuries
Effectiveness of Dental Trauma Educational Poster to Secondary Students
to investigate the effectiveness of the educational poster regarding knowledge of dental trauma for the secondary school students
- Trial name
- NCT01809457
- Testing
- educational poster
- Where
- Hong Kong
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Obesity, Diabetes
Family Weight Management Study
The purpose of this study is to address the Healthy People 2010 obesity prevention objective. This study will test the effects of a comprehensive family weight management program on the BMI z-score of 7-12 year-old children with…
- Trial name
- NCT00851201
- Testing
- Intensive lifestyle, Standard intervention
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Quality of Life, Injection Site Reaction
Simultaneous mRNA COVID-19 and IIV4 Vaccination Study
This study is a prospective, randomized clinical trial. During this study, participants will be randomly assigned to receive quadrivalent inactivated influenza vaccine (IIV4) and mRNA COVID-19 vaccine either simultaneously or…
- Conditions
- Quality of Life, Injection Site Reaction, Adverse Drug Event, Systemic Reaction
- Trial name
- NCT05028361
- Testing
- mRNA COVID-19, IIV4
- Where
- 3 sites in United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Duke University
Kidney Stones
Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy
The Investigators objective is to compare the clinical efficacy of a single-day protocol with a short-course protocol for PCNL. The investigator hope is to reduce the use of possibly unnecessary prolonged antibiotic use, reduce…
- Trial name
- NCT02579161
- Testing
- cephalosporins, Fluoroquinolones, Clindamycin
- Where
- 2 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy
Brain Responses to Intragastric Administration of a Bitter Agonist in Homeostatic and Hedonic Brain Regions
The investigators aim to study the brain mechanisms underlying the effect of subliminal (not consciously perceived) intragastric administration of bitter tastants on hunger and food intake, which was previously found.
- Trial name
- NCT02946970
- Testing
- Quinine hydrochloride, Control
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bioequivalence
The Bioequivalence Study of Two Different Formulations of Olmesartan Medoxomil After a Single Oral Dose Administration Under Fasting Conditions.
This single dose study is designed in accordance with EMA (the European Medicines Agency) regulatory guidelines, with the aim of characterizing the bioavailability of olmesartan in the two formulations in healthy subjects.
- Trial name
- NCT03951051
- Testing
- Olmesartan Medoxomil 40 mg, Olmetec®
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pharmtechnology LLC
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