Clinical trials: Malignant Neck Neoplasm
Cystic Fibrosis
Prospective Observational Study to Evaluate Biomarkers of Aminoglycoside Nephrotoxicity in Patients With Cystic Fibrosis
The project is designed to test new biomarkers that are more sensitive than the current standard in detecting injury to the proximal kidney tubule and will establish better criteria for when kidney safety concerns may halt…
- Trial name
- NCT01543620
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Foundation for the National Institutes of Health
Head and Neck Cancer
Observational Study on Biomarkers in Head and Neck Cancer (HNprädBio)
The aim of this clinical research project is to validate the prognostic impact of potential biomarkers on loco-regional control of locally advanced head and neck cancer after definitive or adjuvant radiochemotherapy.
- Trial name
- HNprädBio (NCT02059668)
- Testing
- Biomarker analyses head & neck cancer tissue, blood specimen
- Where
- 10 sites in Germany
- Volunteers
- 588 people
- Sponsor
- Technische Universität Dresden
Hearing Loss
SSNHL in Head & Neck Cancer Patients
A sound dosimeter will be used to measure noise level to which a population of head and neck patients on the otolaryngology ward are exposed to. The device is the EXTECH 407764 type II sound level meter (IEC 651 RS232).
- Trial name
- NCT04609982
- Testing
- ear plugs
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Head and Neck Cancers
A Prospective, Multicenter, Multicohort Phase II Study: Evaluating the Efficacy and Safety of Preoperative Neoadjuvant Treatment With a PD-1 Inhibitor in Combination With Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) refers to a series of tumors that occur in the head and neck region, including the oral cavity, pharynx, larynx, nasal cavity, paranasal sinuses, thyroid gland, and salivary glands.
- Trial name
- NCT06894459
- Testing
- Pembrolizumab, Cisplatin, Nab-paclitaxel
- Volunteers
- 180 people
- Sponsor
- Beijing Tongren Hospital
Head and Neck Cancer
Cisplatin or Carboplatin Combined With Gemcitabine in Locally Advanced, Recurrent, or Metastatic Malignant Salivary Gland Tumor
RATIONALE: Drugs used in chemotherapy, such as cisplatin, carboplatin, and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving more than one drug may kill more tumor cells.
- Trial name
- NCT00079079
- Testing
- carboplatin, cisplatin, gemcitabine hydrochloride
- Where
- 4 sites in Canada
- Volunteers
- 34 people
- Sponsor
- NCIC Clinical Trials Group
De-escalated Radiotherapy; Head and Neck Cancer
De-Escalation Postoperative Radiotherapy for Oral Squamous Cell Carcinoma With pCR/MPR.
The prognosis of locally advanced oral squamous cell carcinoma(OSCC ) is poor, and there are still many problems to be solved in the current treatment paradigm.
- Trial name
- NCT06353685
- Testing
- Continuous, hyperfractionated, accelerated radiotherapy(CHART)
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Head and Neck Cancer
S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors
RATIONALE: Vandetanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Conditions
- Breast Cancer, Head and Neck Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT00937417
- Testing
- docetaxel, vandetanib, proteomic profiling
- Sponsor
- SWOG Cancer Research Network
CNS Brain Metastases, Head and Neck Cancer
Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients
Hypoxia is a key factor in malignant progression of a neoplasm. It is our aim to explore the basis for quantitative in vivo tumor imaging by Cu-61 diacetyl-bis(N4-methylthiosemicarbazone)PET imaging as a surrogate of tissue…
- Conditions
- CNS Brain Metastases, Head and Neck Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT00585117
- Testing
- PET-imaging with CuATSM, PET Imaging, PET CuATSM
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Head and Neck Squamous Cell Carcinoma
Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients
The purpose of this study is to determine anti-tumor activity by measuring overall response rate in recurrent and/or metastatic HNSCC patients receiving the combination of metformin and pembrolizumab.
- Trial name
- NCT04414540
- Testing
- Metformin Extended Release Oral Tablet, Pembrolizumab
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Trisha Wise-Draper
Head and Neck Cancer
Prognostic Significance of Lymph Node Yield and Lymph Node Ratio Prospective Observational Study
It is still unclear if Lymph Node Yield (LNY) and Lymph Node Ratio (LNR) may have a prognostic role in patients affected by carcinoma of the oral cavity and the oropharynx. Only retrospective studies are available.
- Trial name
- NCT03534778
- Testing
- Lymph Node Yield (LNY) and Lymph Node Ratio (LNR)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- University of Roma La Sapienza
Bladder Cancer, Breast Cancer
A Study Comparing Oral Picoplatin With Intravenous Picoplatin in Subjects With Solid Tumors
Picoplatin is a new platinum-based chemotherapy drug that has been studied in a variety of cancers. Phase 1 and 2 studies have demonstrated that picoplatin may be effective in patients whose cancer returns or does not improve…
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastrointestinal Neoplasm
- Trial name
- NCT00465725
- Testing
- Picoplatin
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Poniard Pharmaceuticals
HNSCC
Trial Combining Pembrolizumab and Cesium 131 Brachytherapy With Salvage Surgery in HNSCC
To Study Perioperative PD-1 Inhibitor and Cesium-131 Interstitial Brachytherapy in patients with locally recurrent HNSCC eligible for salvage surgery.
- Trial name
- NCT04340258
- Testing
- Cesium-131, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Thyroid Pathology, Head and Neck Cancer (H&N)
FAPI PET Imaging - An Exploratory Study
This study is testing a new imaging tracer called [18F]FAPI-74 with PET scans. Researchers want to find out how well this tracer shows certain diseases in the body, including several types of cancer and some non-cancer conditions…
- Conditions
- Thyroid Pathology, Head and Neck Cancer (H&N), Sinonasal Tract Tumor, Sarcoidosis
- Trial name
- FAPIPET (NCT07705074)
- Testing
- [18F]FAPI-74 PET/CT
- Where
- 5 sites in Switzerland
- Volunteers
- 770 people
- Sponsor
- Martin Huellner
Head and Neck Cancer
Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx
Phase I study to assess the feasibility (i.e. early toxicity) of Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx.
- Trial name
- NCT02336711
- Testing
- dose escalation
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Head and Neck Cancer
Cisplatin and RT With or Without Gemcitabine, Carboplatin, and Paclitaxel in Treating Patients With Locally Advanced NPC
RATIONALE: Drugs used in chemotherapy, such as cisplatin, gemcitabine hydrochloride, carboplatin, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Trial name
- NCT00997906
- Testing
- carboplatin,, cisplatin, gemcitabine hydrochloride
- Where
- Singapore
- Volunteers
- 172 people
- Sponsor
- National Cancer Centre, Singapore
Xerostomia
Comparing Over-the-counter Dry Mouth Remedies After Radiation
The purpose of this study is to compare the effectiveness of over-the-counter remedies for dry mouth.
- Trial name
- NCT00595933
- Testing
- sugar-free chewing gum, chewing gum, mouth rinse
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Head and Neck Cancer, Skull Base--Cancer
HRQoL in Patients With Solid Tumors Treated With Hadrontherapy
The Quality of Life of patients treated with hadrontherapy is still limited. Two cohorts are established, they will be receiving specific standardized questionnaires to be evalutaed in their results.
- Conditions
- Head and Neck Cancer, Skull Base--Cancer, Brain Cancer
- Trial name
- HadroQoL (NCT05947149)
- Testing
- questionnaires administration
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Xerostomia
Mesenchymal Stemcells for Radiation Induced Xerostomia
The current study aims to assess the safety and feasibility of the injection of autologous adipost tissue derived MSCs on radiation-induced salivary gland hypofunction and xerostomia in head and neck cancer participants.
- Trial name
- MESRIX (NCT02513238)
- Testing
- Mesenchymal stem cell, Isotonic NaCl
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Advanced Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition
This is a single-arm, non-randomized pilot study to evaluate the efficacy and tolerability of combination quad-shot palliative radiotherapy with immunotherapy for advanced/recurrent/metastatic head and neck cancer.
- Conditions
- Advanced Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head-and-neck Squamous-cell Carcinoma, Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck
- Trial name
- NCT04454489
- Testing
- Pembrolizumab (immunotherapy), Quad-shot palliative radiotherapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wake Forest University Health Sciences
Head and Neck Cancer
3'-Deoxy-3'-[18F] Fluorothymidine and Fludeoxyglucose F 18 PET Scans in Evaluating Response to Cetuximab, Cisplatin, and Radiation Therapy in Patients With Advanced Cancer of the Oropharynx, Larynx, or Hypopharynx
RATIONALE: Diagnostic procedures, such as 3'-deoxy-3'-[18F] fluorothymidine (FLT) and fludeoxyglucose F 18 (FDG) PET scans, may help doctors predict a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00757549
- Testing
- cetuximab, cisplatin, TdT-mediated dUTP nick end labeling assay
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic