Clinical trials: Malignant Neck Neoplasm
Oral Mucositis, Stomatitis
Prospective Study of Head and Neck Cancer Radiation Treatment With or Without Amifostine
The purpose of this study is to compare the incidence of stomatitis when treating with amifostine before radiation treatment.
- Trial name
- NCT01288625
- Testing
- Amifostine
- Sponsor
- Sun Pharmaceutical Industries Limited
Head and Neck Cancer, Thromboembolism
Flavopiridol in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of flavopiridol in treating patients who have…
- Trial name
- NCT00020189
- Testing
- acetylsalicylic acid, alvocidib, clopidogrel bisulfate
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Squamous Cell Carcinoma
2B or Not 2B? Shoulder Function After Level 2B Neck Dissection: A Randomized Controlled Study
Many types of head and neck cancers will have local spread to the neck. As such selective neck dissection is performed as part of the treatment. The neck is divided into various levels.
- Trial name
- 2BN2B (NCT00765791)
- Testing
- Selective Neck Dissection Excluding Level 2B, Selective Neck Dissection Including Level 2B
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Head and Neck Cancer, Nutrition
Immunonutrition Effects on Nutrition and Immunity in HNC During Radiotherapy
Head and neck cancer (HNC) is one of the most common types of malignant tumors, often leading to malnutrition due to its complex anatomical location near many functional organs.
- Trial name
- NCT07017218
- Testing
- IMPACT
- Volunteers
- 48 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Head and Neck Carcinoma, Localized Head and Neck Carcinoma
Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatment (PULS-Pal)
This trial tests how well personalized ultra fractionated stereotactic adaptive radiotherapy (PULSAR) works together with HyperArc© radiation treatment planning technology for palliative (holistic pain and symptom control) tumor…
- Conditions
- Head and Neck Carcinoma, Localized Head and Neck Carcinoma, Metastatic Head and Neck Carcinoma, Recurrent Head and Neck Carcinoma
- Trial name
- PULS-Pal (NCT06572423)
- Testing
- Personalized ultrafractionated stereotactic adaptive radiotherapy, Volume Modulated Arc Therapy, Computed Tomography
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Thyroid Nodule
Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules.
According to the grades of echogenicity to evulated thyroid nodules is a subjective process and is thus influenced by the observer's judgement.
- Trial name
- NCT03700762
- Testing
- ultrasound gray-scale ratio
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Head and Neck Cancer
Oral Decitabine (ASTX727) and Durvalumab in Recurrent and/or Metastatic Head and Neck Cancer Patients
This is a non-randomized, open-label, Phase Ib study to assess the safety and efficacy of a DNA methyltransferase inhibitor and immune checkpoint inhibitor(s) (durvalumab and/or tremelimumab) combination therapy in the treatment…
- Trial name
- NCT03019003
- Testing
- Oral Decitabine, Durvalumab, 5' Azacitidine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck
Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer
Head and neck cancer in its advanced, incurable stage causes severe symptoms such as pain, trouble swallowing, and bleeding. Palliative radiation therapy is frequently used to relieve these symptoms and improve the patient's…
- Trial name
- QSSC-HN (NCT07823309)
- Testing
- Quad Shot Radiotherapy, Split Course Radiotherapy
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Carcinoma of Unknown Primary, Head and Neck Cancer
Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00002507
- Testing
- mitomycin C, porfiromycin, brachytherapy
- Where
- United States
- Sponsor
- Yale University
Head and Neck Cancer
Diet Intervention, Head and Neck Cancer, Feasibility
This study will examine the effects of a dietary intervention in post-treatment head and neck cancer survivors on the ability to function physically, tiredness, and quality of life, as well as on changing markers in the blood…
- Trial name
- NCT03013699
- Testing
- Cruciferous and Dark Leafy Green Intervention, Usual Dietary Care
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Colorectal Cancer, Squamous Cell Head and Neck Cancer
A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers
The purpose of this study was to evaluate the safety and tolerability of escalating doses of the MM-121 plus cetuximab and the MM-121 plus cetuximab plus irinotecan combination.
- Conditions
- Colorectal Cancer, Squamous Cell Head and Neck Cancer, Non-small Cell Lung Cancer, Triple Negative Breast Cancer
- Trial name
- NCT01451632
- Testing
- MM-121, Irinotecan, Cetuximab
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Merrimack Pharmaceuticals
Head and Neck Neoplasms
Use of Cone Beam Kilovoltage Imaging in Patients Receiving Radiation Therapy for Head and Neck Cancer
To evaluate the use of cone beam computed tomography in treating head and neck to hopefully reduce side effects
- Trial name
- NCT00358007
- Testing
- PTV Reduction
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Melanoma
Study of GSK2132231A Antigen-Specific Cancer Immunotherapeutic in Patients With Inoperable Metastatic Cutaneous Melanoma
The clinical objective of this clinical trial is to examine the clinical activity in terms of tumor response and time to treatment failure of the immunotherapeutic product GSK2132231A when given to patients with unresectable and…
- Trial name
- NCT00896480
- Testing
- Immunotherapeutic GSK2132231A
- Where
- 8 sites in Belgium, France
- Volunteers
- 24 people
- Sponsor
- GlaxoSmithKline
Head and Neck Squamous Cell Carcinom, Nasopharyngeal Carcinoma
The Safety and Efficacy of Multiple-dose of JS004 in Subject With HNC
A phase I/II clinical study of JS004 in subjects with head and neck cancer in China, to evaluate the safety, tolerability, PK, immunogenicity, antitumor activity and biomarkers of JS004, define the RP2D.
- Trial name
- NCT04929080
- Testing
- JS004 , Recombinant humanized IgG4k monoclonal antibody specific to BTLA for injection Intravenous infusion, JS001 and JS004
- Where
- China
- Volunteers
- 149 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Cancer of Head Neck, Radiation-Induced Xerostomia
Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients
This randomized control trial aims to investigate the efficacy of oral moisturizing jelly in head and neck cancer patients with xerostomia.
- Conditions
- Cancer of Head Neck, Radiation-Induced Xerostomia, Dry Mouth
- Trial name
- NCT03035825
- Testing
- Oral moisturizing jelly, Artificial saliva
- Where
- Thailand
- Volunteers
- 73 people
- Sponsor
- Dental Innovation Foundation Under Royal Patronage
Head and Neck Cancer
Couple-Based Intervention for Patients With Head and Neck Cancer and Their Partners
The purpose of this study is to determine whether a brief couple-based supportive intervention effectively assists patients and their partners coping with the challenges of head and neck cancer.
- Trial name
- CoupleCare (NCT01785576)
- Testing
- Couple-Based CBT Intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Health
Head and Neck Neoplasms
To Evaluate the Efficacy and Safety of SCB01A in Subjects With r/m Squamous Cell Head and Neck Cancer
The aim of this study is to evaluate the efficacy and safety of i.v. infusion for 24-hour of SCB01A in subjects with squamous cell carcinoma of head and neck who have failed previous platinum based therapies.
- Trial name
- NCT03020823
- Testing
- SCB01A
- Where
- 4 sites in Taiwan
- Volunteers
- 10 people
- Sponsor
- SynCore Biotechnology Co., Ltd.
Neoplasms, Head and Neck, Trismus
Manual Therapy and Use of the Dynasplint for Trismus in Patients With Head and Neck Cancer
The objectives of this pilot study are to determine the effectiveness of a manual therapy (MT) protocol plus the use of a dynamic jaw opening device on the maximal interincisor distance; on trismus symptoms; on pain-disability…
- Trial name
- NCT03178110
- Testing
- Physical therapy and dynasplint
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Head and Neck Cancer
Biomarkers in Tissue Samples From Patients With Recurrent or Metastatic Head and Neck Cancer Treated on ECOG-E1395 and ECOG-E3301
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors predict how well patients will respond to treatment.
- Trial name
- NCT01487733
- Testing
- gene expression analysis, in situ hybridization, immunohistochemistry staining method
- Volunteers
- 155 people
- Sponsor
- Eastern Cooperative Oncology Group
Head and Neck Cancer
Optimising Microsurgical Reconstruction After Advanced Head and Neck Cancers
This study aims to improve the peri- and postoperative care regimen for patients undergoing microvascular reconstruction after head and neck cancer by introducing an enhanced recovery after surgery (ERAS) programme.
- Trial name
- NCT04308525
- Testing
- Early ambulation, Early oral feeding, Multimodal opioid-sparing analgesia
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet