Clinical trials: Malignant Female Reproductive System Neoplasm
Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer
CT-95 in Advanced Cancers Associated With Mesothelin Expression
This is a Phase 1a/1b, first-in-human (FIH), open-label, multi-center dose escalation and expansion study of the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of single-agent CT-95 in subjects with…
- Conditions
- Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer, Malignant Pleural Mesothelioma, Advanced, Malignant Peritoneal Mesothelioma, Advanced
- Trial name
- NCT06756035
- Testing
- CT-95
- Where
- 9 sites in United States
- Volunteers
- 70 people
- Sponsor
- Context Therapeutics Inc.
Gynecologic Cancer, Organoid
Construction of Gynecological Tumor Organoids
This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.
- Trial name
- NCT06155370
- Testing
- construction of organoids from gynecological tumor
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Lymphocele, Gynecologic Cancer
Impact of Peritoneal Closure and Retroperitoneal Drainage on Patients Who Underwent Laparotomic Retroperitoneal Lymph Node Dissection
To elucidate whether peritoneal closure and retroperitoneal drainage can benefit clinical outcome of early gynecologic cancer patients who underwent retroperitoneal lymph node dissection.
- Trial name
- NCT03765320
- Testing
- Peritoneal closure, Retroperitoneal drainage
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- Far Eastern Memorial Hospital
Endometrial Serous Adenocarcinoma, Fallopian Tube Carcinoma
Comprehensive Patient Questionnaires in Predicting Complications in Older Patients With Gynecologic Cancer Undergoing Surgery
This research trial studies comprehensive patient questionnaires in predicting complications in older patients with gynecologic cancer undergoing surgery.
- Conditions
- Endometrial Serous Adenocarcinoma, Fallopian Tube Carcinoma, Malignant Female Reproductive System Neoplasm, Ovarian Carcinoma
- Trial name
- NCT02315469
- Testing
- Comprehensive Geriatric Assessment, Questionnaire Administration
- Where
- 393 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- NRG Oncology
Advanced Malignant Neoplasm, Castleman Disease
Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease
This phase I trial studies the side effects and best dose of bevacizumab and temsirolimus alone or in combination with valproic acid or cetuximab in treating patients with a malignancy that has spread to other places in the body…
- Conditions
- Advanced Malignant Neoplasm, Castleman Disease, Digestive System Carcinoma, Erdheim-Chester Disease
- Trial name
- NCT01552434
- Testing
- Bevacizumab, Cetuximab, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer-associated Thrombosis, Venous Thromboembolism
The Gynecological Cancer Associated Thrombosis (GynCAT) Study
GynCAT is a prospective cohort study that will be conducted on female patients with gynecologic malignancies scheduled for systemic antineoplastic treatment, aiming at development and validation of a Risk Assessment Model (RAM)…
- Conditions
- Cancer-associated Thrombosis, Venous Thromboembolism, Gynecologic Cancer, Ovarian Cancer
- Trial name
- GynCAT (NCT06284343)
- Testing
- Anticoagulant
- Where
- Italy
- Volunteers
- 1,800 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sexual Dysfunctions, Psychological, Uterine Cervical Neoplasms
A Randomized Controlled Trial of an Online Support Group for Sexual Distress Due to Gynecologic Cancer
There is a high prevalence of sexual and body image problems among women treated for gynecologic cancer, which can lead to considerable distress.
- Conditions
- Sexual Dysfunctions, Psychological, Uterine Cervical Neoplasms, Ovarian Neoplasms, Uterine Neoplasms
- Trial name
- NCT01654458
- Testing
- GyneGals Support Group
- Where
- 7 sites in United States, Canada
- Volunteers
- 398 people
- Sponsor
- Women's College Hospital
Advanced Digestive Cancer, Advanced Gynecologic Cancer
Identification of Innovative Biomarkers Related to the Immune System or Tumor Microenvironment to Promote the Efficacy of Immunotherapies
The immune system may be involved in the recognition and destruction of tumor cells or cells undergoing transformation. It is also currently accepted that the quality of immune responses can influence the evolution of cancers…
- Trial name
- HORIZON (NCT06626269)
- Testing
- Blood sample, Tumor tissue
- Where
- 2 sites in France
- Volunteers
- 700 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Breast Cancer Female, Gynecologic Cancer
Transcranial Magnetic Stimulation for Chemotherapy-Induced Peripheral Neuropathy in Breast and Gynecologic Cancer Survivors
The goal of this study is to evaluate the change in pain scores among patients with chemotherapy-induced peripheral neuropathy after receiving treatment with repetitive transcranial magnetic stimulation (rTMS).
- Trial name
- rTMS for CIPN (NCT07120100)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Utah
Gynecologic Cancer
Comprehensive Assessment of Clinical Characteristics and Outcomes of Gemelli Adolescents and Young Adults
The Adolescent and Young Adults cancer population encompass patients diagnosed with oncological disease at the age of 15-39 years.
- Trial name
- G-AYA (NCT06594471)
- Testing
- Questionnaire on late-term physical effects, Questionnaire on sexual and reproductive health outcomes, Questionnaire on psychological outcomes
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Medical Education, Ovarian Cancer
Ultrasound Training Program for Gynecologic Cancer Staging in Residents
This is a prospective, interventional study aiming to develop and validate an ultrasound training program for gynecology and obstetrics residents, focused on the staging of gynecologic cancers, including ovarian, endometrial, and…
- Conditions
- Medical Education, Ovarian Cancer, Endometrial Cancer, Cervix Cancer
- Trial name
- Ultra-teaching (NCT07028229)
- Testing
- Training Group
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Cancer, Chemotherapy-induced Nausea and Vomiting
Adherence to the Antiemesis National Comprehensive Cancer Network (NCCN) Guideline
This study aims to investigate the adherence to the antiemesis NCCN guideline in Chinese patients of gynecologic malignancies, who are given chemotherapy treatment.
- Trial name
- NCT03740672
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Lei Li
Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Cancer Metastatic
Evaluating Efficacy and Tolerability of Anticancer Drug Therapies for the Treatment of Gynecologic and Breast Cancers
retrospective/prospective observational study. Objective of the study is to evaluate the effect of drugs in terms of objective responses, disease-free survival (DFS), progression-free survival (PFS), overall survival (OS), and…
- Conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Cancer Metastatic, Ovarian Cancer, Cervical Carcinoma
- Trial name
- NCT06800612
- Testing
- Oncologic drugs administered for treatment of breast cancer, Oncologic drug administered for treatment of gynecologic cancer
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cancer
Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant
RATIONALE: Giving donor natural killer cells to patients who have undergone donor bone marrow transplant may make the transplant work better and keep cancer cells from coming back.
- Trial name
- NCT00569283
- Testing
- therapeutic allogeneic lymphocytes
- Where
- 2 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- Asan Medical Center
Gynecologic Cancer, Breast Cancer
Electronic Patient Reported Symptom Assessment
The purpose of this study is to assess whether using computerized screening questions can improve how well we manage symptoms related to cancer and cancer treatments.
- Conditions
- Gynecologic Cancer, Breast Cancer, Thoracic Cancer, Gastrointestinal Cancer
- Trial name
- NCT01833637
- Testing
- APN Intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Northwestern University
Gynecologic Cancer, Surgery
GO SOAR1: Post-Operative Morbidity and Mortality Following Gynaecological Oncology Surgery
The Global Gynaecological Oncology Surgical Outcomes Collaborative (GO SOAR) will develop a network of gynaecological oncology surgeons, surgical departments and other interested parties that will have the long-term ability to…
- Conditions
- Gynecologic Cancer, Surgery, Surgery--Complications
- Trial name
- GO SOAR1 (NCT04579861)
- Testing
- Prospective data collection following gynaecological oncology surgery
- Where
- United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- Faiza Gaba
Low Anterior Resection Syndrome, Malignant Anal Neoplasm
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to…
- Conditions
- Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm
- Trial name
- NCT04066894
- Testing
- Explantation, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer, Gastro-intestinal Cancer
The SOAR Study: a Study of Geriatric Assessment and Exercise for Older Adults and Their Support Person
Phase 2 randomized controlled study using a waitlist control group. The study also has a single arm pre-post test 12-week chair-based exercise arm for those who have received the geriatric assessment in the older adults with…
- Conditions
- Lung Cancer, Gastro-intestinal Cancer, Genito-Urinary Cancer, Breast Cancer
- Trial name
- SOAR (NCT05509751)
- Testing
- GAM, exercise, health education, online chair-based exercise combined with health education
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Martine Puts
Breast Cancer, Digestive Cancer
Interest of Circulating Tumor DNA in Digestive and Gynecologic/Breast Cancer
Circulating tumor DNA (ctDNA) offers the possibility of accessing the tumor genome from circulating blood through a simple blood test.
- Conditions
- Breast Cancer, Digestive Cancer, Gynecologic Cancer, Circulating Tumor DNA
- Trial name
- NCT04530890
- Testing
- Blood samples
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Mesonephric Gynecologic Cancer
A Study of Avutometinib (VS-6766) and Defactinib in People With Mesonephric Gynecologic Cancer
This study will test if Avutometinib (VS-6766) in combination with Defactinib is an effective treatment for advanced or recurrent mesonephric gynecologic cancer.
- Trial name
- NCT05787561
- Testing
- Avutometinib (VS-6766), Defactinib
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center