Clinical trials: Malignant Biliary Obstruction
Biliary Tract Neoplasms, Biliary Drainage
Suprapapillary Versus Transpapillary Plastic Stents for Unresectable Malignant Hilar Biliary Obstruction
Bile duct blockage caused by cancer near the liver hilum (where the bile ducts join) leads to jaundice and infection. The standard treatment is to place a plastic stent (a small tube) through an endoscope to drain the bile.
- Conditions
- Biliary Tract Neoplasms, Biliary Drainage, Malignant Biliary Obstruction, Obstructive Jaundice
- Trial name
- NCT07811791
- Testing
- Suprapapillary plastic stent placement, Transpapillary plastic stent placement
- Where
- 8 sites in Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Endoscopic Retrograde Cholangiopancreatography, Biliary Drainage
EUS-guided Biliary Drainage of First Intent With the Lumen Apposing Metal Stent vs. ERCP in the Management of Malignant Distal Biliary Obstruction (AXIOS-CPRE)
The main objective is to compare the EUS-BD with the insertion of a LAMS vs. traditional ERCP to restore biliary patency. Although ERCP has been the primary treatment for many years, it is associated with a significant risk of…
- Conditions
- Endoscopic Retrograde Cholangiopancreatography, Biliary Drainage, Echography Ultrasound
- Trial name
- AXIOS-CPRE (NCT05122858)
- Testing
- EUS guided biliary drainage, ERCP
- Where
- France
- Volunteers
- 15 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Biliary Tract Neoplasms, Pancreatic Neoplasms
RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction
Less than 20% of patients with malignant distal bile duct (BD) obstruction (often pancreatic cancer) are suitable for resection surgery.In the rest,palliation treatment comes into focus.
- Conditions
- Biliary Tract Neoplasms, Pancreatic Neoplasms, Stent Occlusion
- Trial name
- NCT00980889
- Testing
- Steel, Nitinol
- Where
- 11 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Stockholm South General Hospital
Cholangiocarcinoma, Gallbladder Cancer
A Study for Efficacy of Side-by-side Compared to Stent-in-stent Technique in the Endoscopic Management of Malignant Hilar Biliary Obstruction
Malignant obstructive jaundice is a common complication of advanced stage cholangiocarcinoma, GB cancer, and pancreatic cancer. In biliary stricture by malignancy, biliary drainage with placement of self-expanding metal stent…
- Conditions
- Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, HCC
- Trial name
- NCT02659852
- Testing
- side by side, stent in stent
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Pancreatic Cancer, Endoscopy
Plastic Stent Within a Lumen-Apposing Stent for Malignant Biliary Obstruction
There are doubts concerning the possible benefits derived from the insertion of double-pigtail plastic stents (DPS) within the lumen-apposing metal stents (LAMS) in the EUS-guided transmural biliary drainage (BD).
- Conditions
- Pancreatic Cancer, Endoscopy, Oncologic Disorders, Therapy Related Neoplasms
- Trial name
- LAMSpigBil (NCT04420039)
- Testing
- Endoscopic biliary transmural drainage
- Where
- 3 sites in Spain
- Volunteers
- 39 people
- Sponsor
- Hospital Universitari de Bellvitge
Stricture, Obstruction
Patency of a Prototype Large Plastic Biliary Stent in the Palliation of Malignant Distal Biliary Strictures.
Plastic biliary stents which are a new larger size will remain free of obstructions for a longer period of time than currently used 10 French stents in cancer in the common bile duct.
- Conditions
- Stricture, Obstruction, Cancer
- Trial name
- NCT01590394
- Testing
- Large plastic biliary stent
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Malignant Biliary Obstruction
Comparison Between Novel Flower-type Covered Stent and Conventional Covered Stent
The aim of this animal study is determining the technical feasibility of the novel flower-type covered self-expandable metal stent (F-CSEMS) and investigating whether the novel flower-type covered self-expandable metal stent…
- Trial name
- NCT03215108
- Testing
- Endoscopic Retrograde CholangioPancreatography(ERCP)
- Where
- South Korea
- Volunteers
- 256 people
- Sponsor
- Samsung Medical Center
Biliary Obstruction, Bile Duct Stones
Comparison Between Winged Versus Traditional Plastic Stents for Biliary Drainage
This study was randomized, controlled, blinded trial with a two-arm parallel-group design to directly compare the therapeutic outcomes of winged versus conventional stents in patients with benign or malignant biliopancreatic…
- Conditions
- Biliary Obstruction, Bile Duct Stones, Biliary Tract Cancer
- Trial name
- NCT06960733
- Testing
- Winged plastic stent, Standard plastic stents
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- University of Leipzig
Bile Duct Obstruction
Paclitaxel Eluting Covered Metallic Stent for Unresectable Malignant Bile Duct Obstruction
The primary goal is to determine stent patency and overall survival of the conventional covered self expandable metallic stent versus paclitaxel eluting covered self expandable metallic stent in unresectable malignant bile duct…
- Trial name
- NCT00453076
- Testing
- Paclitaxel eluting covered metal stent and control covered metal stent
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Asan Medical Center
Biliary Stricture
A Study of Endobiliary Radiofrequency Ablation in Malignant Biliary Obstructions
The purpose of this study is to assess the impact of temperature-sensitive radiofrequency ablation (RFA) immediately before biliary stent placement on duration of biliary stent patency and re-intervention free survival.
- Trial name
- NCT05826639
- Testing
- Temperature-sensitive radiofrequency ablation, No intervention
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Mayo Clinic
DISTAL MALIGNANT BILIARY OBSTRUCTION
Eus-giuded Biliary Drainage With Ec-lams vs ERCP as a Primary Intervention for Endoscopic Treatment of Patinets With Distal Malignant Biliary Obstruction
Endoscopic retrograde cholangiopancreatography (ERCP) is the gold standard for the management of jaundice in patients with distal malignant biliary obstruction.
- Trial name
- EUS-BD (NCT04099862)
- Testing
- ERCP, EUS-BD
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Clinico Humanitas
Cholestasis, Extrahepatic
EUS-guided Biliary Drainage Versus Percutanenous Transhepatic Biliary Darinage for Malignant Biliary Obstruction After Failed ERCP
Although ERCP is almost always successful in patients with malignant biliary obstruction, selective biliary cannulation fails in some cases and conventional ERCP may not be possible in patients with tumor invasion of the duodenum…
- Trial name
- NCT02103413
- Testing
- EUS-BD, PTBD
- Where
- 2 sites in South Korea
- Volunteers
- 66 people
- Sponsor
- Asan Medical Center
Pancreatic Cancer, Malignant Biliary Obstruction
Comparison of a Short Modified Metal Stent Versus Plastic Stent as a Bridge to Surgery in Pancreatic Cancer With Malignant Biliary Obstruction
This study is a multicenter, randomized clinical trial designed to compare the effectiveness and safety of a modified 8-mm fully covered self-expandable metal stent (FCSEMS) with a conventional plastic stent for preoperative…
- Trial name
- BRIDGE-8 (NCT07606430)
- Testing
- Modified 8-mm Fully Covered Self-Expandable Metal Stent, Plastic stent
- Volunteers
- 116 people
- Sponsor
- Soonchunhyang University Hospital
Tumor Appearance of Biliary System Obstruction
Prospective Study Comparing EUS vs ERCP Stent Insertion for Malignant Biliary Obstruction
1. Purpose of the study -To compare stent patency and complication rate between endoscopic ultrasound (EUS) guided stent insertion and endoscopic retrograde cholangiopancreatography (ERCP) guided stent insertion for malignant…
- Trial name
- NCT01421836
- Testing
- ERCP-guided stent insertion, EUS guided stent insertion
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Malignant Biliary Obstruction
IRS(Irradiation Stent) vs. CS(Conventional Stent) Insertion in Inoperable Malignant Biliary Obstruction
Stenting the malignant biliary obstruction is considered to be the preferred palliation modality to relieve pruritus,cholangitis,pain and jaundice in patients without surgical indications of malignant biliary obstruction.An…
- Trial name
- IRCSMBO (NCT02001779)
- Testing
- Biliary SEMS loaded with 125I seeds, Conventional biliary SEMS
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Zhongda Hospital
Extrahepatic Cholangiocarcinoma, Malignant Biliary Obstruction
Spyglass+RFA Versus Cytobrush+RFA for Extrahepatic Cholangiocarcinoma
With the development of endoscopic technology, endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of extrahepatic cholangiocarcinoma.In patients with extrahepatic…
- Trial name
- NCT05233293
- Testing
- Spyglass + RFA, Cytobrush + RFA
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First People's Hospital of Hangzhou
Malignant Biliary Obstruction, Pancreatic Cancer
EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial)
The aim of this clinical trial is to evaluate temporal delay (days) between biliary drainage (EUS-CDS vs ERCP as first line therapy) and chemotherapy start in patients with borderline distal malignant biliary obstruction.
- Conditions
- Malignant Biliary Obstruction, Pancreatic Cancer, Biliary Tract Neoplasms
- Trial name
- NCT06375954
- Testing
- Endoscopic biliary drainage, Self-expandable metallic stent (SEMS), Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS)
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari de Bellvitge
Obstruction of Biliary Tree, Cholangiocarcinoma
Comparison Between Unilateral Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction to Use a LCD Stent
Internal biliary drainage is an useful method for a control of jaundice and cholangitis to patients who had a malignant hilar obstruction due to hepatocellular carcinoma, cholangiocarcinoma, gall bladder cancer or metastatic…
- Conditions
- Obstruction of Biliary Tree, Cholangiocarcinoma, Hepatocellular Carcinoma, Malignant Lymphadenopathy
- Trial name
- NCT01875549
- Testing
- stent insertion, Endoscopic retrograde cholangiopancreatoscopy(ERCP)
- Sponsor
- Kwang Hyuck Lee
Biliary Tract Neoplasms
Radiofrequency Ablation for Malignant Biliary Obstruction
Biliary obstruction is importantly influencing quality of life and survival of patients suffering from primary or secondary bile duct malignancies.
- Trial name
- NCT01758341
- Testing
- Endoscopic radiofrequency ablation, Endoscopic retrograde cholangiopancreatography (ERCP), HabibTM EndoHPB catheter
- Where
- Austria
- Volunteers
- 58 people
- Sponsor
- Medical University of Vienna
Biliary Tract Neoplasms, Jaundice, Obstructive
Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents
Endoscopic retrograde biliary drainage (ERBD) is now widely accepted as the standard intervention for the relief of obstructive jaundice in patients with unresectable malignant biliary obstruction.
- Trial name
- NCT01315522
- Testing
- ComVi stent, Uncovered SEMS
- Where
- 3 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital