Clinical trials: Male Circumcision
HIV Infections, Herpesvirus 2, Human
Male Circumcision for HIV Prevention in Rakai, Uganda
Circumcision in HIV unifected men may reduce the likelihood of becoming infected with HIV, reduce sexually transmitted infections (STIs) in men, not engender increases in sexual risk behaviors, and be acceptable to men as a…
- Conditions
- HIV Infections, Herpesvirus 2, Human, Syphilis, Genital Diseases, Male
- Trial name
- NCT00425984
- Testing
- Adult male circumcision
- Where
- Uganda
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Comparing the PrePex™ Device to Surgical MC for Rapid Scale Up of MC in Resource Limited Setting
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Trial name
- NCT01956370
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Zimbabwe
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
HIV Infections
Male Circumcision and HIV Rates in Kenya
The Luo tribe of Kisumu, Kenya, does not traditionally practice male circumcision (MC). This study will work with the Luo tribe to test the effectiveness of MC on reducing the risk of HIV infections in young men.
- Trial name
- NCT00059371
- Testing
- male circumcision
- Where
- Kenya
- Volunteers
- 2,887 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Circumcision, Male
Unicirc Adolescent 12-15 Year Old Boys
This is a field case series of Unicirc under topical anaesthetic among adolescent boys, aged 12 to 15 years.
- Trial name
- NCT02593630
- Testing
- Unicirc circumcision
- Where
- South Africa
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Simunye Primary Health Care
Voluntary Medical Male Circumcision
Two-way Texting for VMMC Follow-up in Republic of South Africa
Voluntary medical male circumcision (alternatively abbreviated in the literature as VMMC or MC) is a critical HIV prevention intervention with global support for expansion across sub-Saharan Africa (SSA).
- Trial name
- 2wT_RSA (NCT04327271)
- Testing
- Text-based VMMC follow-up
- Where
- 9 sites in South Africa
- Volunteers
- 1,093 people, healthy volunteers welcome
- Sponsor
- University of Washington
Phimosis, Paraphimosis
Evaluating the Efficacy of 2-Octyl Cyanoacrylate (2-OCA) With Four Interrupted Sutures in Adult Male Circumcision
This study aims to determine whether cyanoacrylate glue is a non-inferior alternative to continuous suturing for wound closure following adult circumcision.
- Trial name
- NCT06487494
- Testing
- Circumcision wound closure using 2-octyl cyanoacrylate glue with four interrupted sutures, Circumcision wound closure using continuous sutuing
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Circumcision, Male
The Safety of Thermocautery Usage for Male Children's Circumcisions
Since circumcision is a significant workload for surgeons working at the rural state hospitals in Turkey, the use of circumcision techniques that are easy to implement and have low complications is becoming widespread.
- Trial name
- MC (NCT03305523)
- Testing
- Thermocautery
- Volunteers
- 1,780 people, healthy volunteers welcome
- Sponsor
- Kocatepe University
Voluntary Medical Male Circumcision
Text-based Follow-up in Zimbabwe's Voluntary Medical Male Circumcision Program
Voluntary medical male circumcision (VMMC) in sub-Saharan Africa is safe: the average rate of moderate and severe adverse events (AEs) at the country level is 0.8%, corresponding to 99% of men healing without incident.
- Trial name
- 2WT (NCT03119337)
- Testing
- Text-based follow-up
- Where
- 5 sites in Zimbabwe
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- University of Washington
Inguinal Hernia
Neuroinflammatory and Neurocognitive Effects of Spinal vs. Inhalational Anesthesia for Elective Surgery in Infants
Significant concern regarding the safety of general anesthesia in children has arisen due to myriad animal studies suggesting neurotoxicity of commonly used anesthetic agents.
- Trial name
- NCT02521831
- Testing
- Spinal Anesthesia (bupivacaine), General Anesthesia (isoflurane)
- Sponsor
- Emmett Whitaker, M.D.
HIV Infections
Evaluation of the Extension at Community Level of Safe Male Circumcision (ANRS 12126 ORANGE FARM 2)
This study is aimed at demonstrating whether or not Male Circumcision can be used as an effective public health prevention tool that will have an impact on HIV prevalence in the South African population.
- Trial name
- ORANGE FARM 2 (NCT00623051)
- Testing
- Male Circumcision
- Where
- South Africa
- Volunteers
- 27,000 people, healthy volunteers welcome
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Sexual Behavior, Dis-inhibition
Information About HIV Transmission and Circumcision on Subsequent Sexual Behavior, and the Demand for Circumcision
The purpose of this study is to measure the behavioral effects of learning information about male circumcision and HIV risk on sexual behavior and the demand for male circumcision.
- Trial name
- NCT01895556
- Testing
- Information, Control
- Volunteers
- 1,200 people
- Sponsor
- Rebecca Thornton
Postoperative Delirium, Pediatric Anesthesia
Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision
Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data…
- Conditions
- Postoperative Delirium, Pediatric Anesthesia, Inflammatory Biomarkers
- Trial name
- NCT07323485
- Testing
- Measurement of Preoperative Inflammatory Biomarkers
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Phimosis
Does Neurostimulation Improve Efficacy for Ultrasound-Guided Transperineal Pudendal Nerve Block In Children
This study aim to compare efficacy of transperineal pudendal nerve block between 2 techniques, by dual guidance (ultrasound and neurostimulation) vs by ultrasound-guided only, in pediatric patients who undergo circumcision.
- Trial name
- NCT03931850
- Testing
- Pudendal nerve block
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Anxiety, Pain, Postoperative
Nursing Intervention Program in the Management of Parental Anxiety and Infant Pain in the Surgical Process of Children to be Circumcised
Entering the hospital and waiting for surgery is a very stressful time for people. According to some studies, surgical interventions in children generate in family members concerns related to: anesthesia, fear of being harmed…
- Conditions
- Anxiety, Pain, Postoperative, Child Development
- Trial name
- NCT05387291
- Testing
- Intervention group, Control group
- Where
- Spain
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Universitat de Girona
Circumcision Adult, HIV CDC Category B2
Evaluation of Safety and Efficacy of the PrePexTM Device for Rapid Scale up of Adult MC Programs in Zimbabwe
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Conditions
- Circumcision Adult, HIV CDC Category B2, HIV Infections
- Trial name
- ZW-01 (NCT01956396)
- Testing
- PrePex™ device
- Where
- Zimbabwe
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
Male Circumcision
High Volume Caudal Study
The primary objective is to evaluate the effect of clonidine on the duration of analgesia provided by a high volume-low concentration caudal block for pediatric aurgical procedres.
- Trial name
- NCT04263064
- Testing
- High Volume-Low Concentration without Clonidine, High Volume-Low Concentration with clonidine
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Neonate, Circumcision
Dilemma of Neonatal Circumcision in Egypt
The study aims to compare wound healing, wound healing complications, cosmetic outcome, and level of parental satisfaction amongst four techniques of neonatal circumcision.
- Trial name
- NCT07076992
- Testing
- Circumcision by Plastibell, Circumcision by Gomco
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Circumcision
Evaluation of the ShangRing vs. Mogen Clamp for Early Infant Male Circumcision (EIMC) in Sub-Saharan Africa
The study will evaluate the safety and acceptability of the topical anesthesia-based, no-flip ShangRing technique vs. Mogen clamp for Early Infant Male Circumcision (EIMC) in neonates and infants up to 60 days of life.
- Trial name
- NCT03338699
- Testing
- ShangRing, Mogen clamp
- Where
- 3 sites in Kenya, Tanzania and 1 more
- Volunteers
- 1,380 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
HIV/AIDS
Manicaland VMMC Uptake Through Behavioural Incentives Trial
Primary Objective The purpose of this study is to evaluate the impact of an interactive VMMC education session offered by a circumcised health worker and contribution to transport costs for accessing VMMC along with either (1)…
- Trial name
- NCT03565588
- Testing
- Education session with fixed incentive, Education session with lottery incentive
- Where
- 7 sites in Zimbabwe
- Volunteers
- 1,028 people, healthy volunteers welcome
- Sponsor
- Simon Gregson
Circumcision, Male
Study on the Protective Effect of a Flexible Sleeve Penis Protection Device on Penis After Circumcision
Circumcision is a common clinical procedure for both circumcision and phimosis, which are common disorders of the male reproductive system.
- Trial name
- NCT05764889
- Testing
- wrapped with the Flexible Sleeve Penis Protection Device, wrapped with traditional gauze
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Liu Zhuo