Clinical trials: Malaria, Pregnancy
Malaria, Falciparum Malaria
Malaria Molecular Surveillance in Mozambique (Phase 2)
Mozambique is among the ten countries with the highest burden of malaria worldwide, with an estimated 10.3 million cases in 2021.
- Conditions
- Malaria, Falciparum Malaria, Malaria in Pregnancy
- Trial name
- GenMoz2 (NCT06529237)
- Testing
- LDH-based malaria rapid diagnostic test, Malaria rapid diagnostic test
- Where
- Mozambique
- Volunteers
- 18,750 people, healthy volunteers welcome
- Sponsor
- Centro de Investigacao em Saude de Manhica
HIV, Pregnancy Malaria
A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIV
More than 3 billion people worldwide are at risk of acquiring malaria and pregnant women living with HIV in Africa are at particular risk.
- Conditions
- HIV, Pregnancy Malaria, Sexually Transmitted Infection
- Trial name
- PREMISE (NCT03431168)
- Testing
- Azithromycin/TMPS
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- University of Alabama at Birmingham
Pregnancy Complications Parasitic
Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria
The study has two components: component A is a cohort study to determine the in vivo efficacy of SP to clear and prevent malaria parasitaemia in asymptomatic pregnant women and component B is a cross sectional study of women…
- Trial name
- OR1 (NCT01636895)
- Testing
- Efficacy of suphladoxine/pyrimethamine as IPTp
- Where
- Nigeria
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium, UK
Malaria in Pregnancy
New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa
Malaria in pregnancy contributes substantially to maternal anaemia and low birth weight: effective malaria control in pregnancy could avoid about 10,000 maternal and up to 200,000 infant deaths every year.
- Trial name
- NCT00730366
- Testing
- sulfadoxine-pyrimethamine, Chloroquine
- Where
- Burkina Faso
- Volunteers
- 2,766 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Pregnancy Malaria, Bacterial Vaginoses
The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract
Malaria in pregnancy has devastating consequences for mother and foetus. WHO recommends intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) for asymptomatic women, but high-level parasite…
- Conditions
- Pregnancy Malaria, Bacterial Vaginoses, Trichomonas Vaginitis
- Trial name
- NCT04189744
- Testing
- IPTp-sulphadoxine-pyrimethamine plus metronidazole, IPTp-dihydroartemisinin-piperaquine plus metronidazole, IPTp-sulphadoxine-pyrimethamine
- Where
- Zambia
- Volunteers
- 5,436 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Pregnancy Malaria
Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania
Sulfadoxine-pyrimethamine (SP) is currently recommended by the World Health Organization for use as intermittent preventive treatment against malaria in pregnancy (IPTp) in areas of moderate to high malaria transmission.
- Conditions
- Malaria, Pregnancy Malaria, Cardiotoxicity, Cardiac Safety
- Trial name
- NCT02909712
- Testing
- sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DHA-PQP)
- Where
- Tanzania
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Pregnancy Malaria
Assessing to What Extent Dhps-431V Mutation May Influence the Protective Efficacy of IPTp-SP
Malaria in pregnancy (MiP) continues to be a significant public health issue, particularly in sub-Saharan Africa. The coverage of pregnant women with three or more doses of intermittent preventive treatment using…
- Trial name
- DEEM-FIT (NCT04634695)
- Where
- 2 sites in Nigeria
- Volunteers
- 288 people
- Sponsor
- Obafemi Awolowo University
Intermittent Preventive Treatment In Pregnancy (IPTp)
Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa
The primary objective is to establish superiority of AZCQ over SP in protective efficacy for IPTp as measured by the proportion of subjects with sub-optimal pregnancy outcome.
- Trial name
- NCT01103063
- Testing
- Azithromycin plus chloroquine, sulfadoxine-pyrimethamine
- Where
- 9 sites in Benin, Kenya and 3 more
- Volunteers
- 2,891 people, healthy volunteers welcome
- Sponsor
- Pfizer
Malaria
Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine Candidates
Background: Malaria is a disease that affects many people in African countries. It is caused by germs that are spread by mosquito bites. It can be fatal if not diagnosed and treated right away.
- Trial name
- NCT02471378
- Where
- Mali
- Volunteers
- 7,476 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria in Pregnancy
TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study
The main objective of this study is to monitor SP resistance via molecular markers in the context of the TIPTOP project implementation of community distributed SP for women during pregnancy.
- Trial name
- TIPTOP-DRS (NCT03998839)
- Testing
- Community distribution of Sulfadoxine-pyrimethamine (SP)
- Where
- 4 sites in Democratic Republic of the Congo, Madagascar and 2 more
- Volunteers
- 7,200 people
- Sponsor
- Jhpiego
Malaria, Pregnancy
A New Approach to Deliver Malaria Preventions to Pregnant Women at a Community Level in Uganda
SUMMARY Background: Malaria is the leading cause of morbidity and mortality among pregnant women in Uganda. Although effective tools for prevention and control of malaria exist, their delivery presents a problem.
- Conditions
- Malaria, Pregnancy, Anemia
- Trial name
- NCT00118027
- Testing
- sulphadoxine-pyrimethamine intermittent preventive treatment
- Where
- Uganda
- Volunteers
- 2,150 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Chlorproguanil-Dapsone in Pregnant Women
Controlling malaria during pregnancy is a vital strategy in decreasing maternal and child mortality in Africa. There are data from clinical trials and program evaluations in stable transmission areas that show that intermittent…
- Trial name
- NCT00126971
- Testing
- chlorproguanil-dapsone
- Where
- Mali
- Volunteers
- 132 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria in Pregnancy
Follow-up of Immunological Pattern and Pregnancy Outcomes in Women Previously Received Placental Malaria Vaccine
Study Population: Participants of the previous PRIMVAC vaccine trial and women aged 18 to 35 years Sample Size: 90 Study duration: 21 months Subject duration: 12 months if pregnancy doesn't occurred.
- Trial name
- PRIMVACLongT (NCT05426187)
- Where
- Burkina Faso
- Volunteers
- 90 people
- Sponsor
- Groupe de Recherche Action en Sante
Malaria in Pregnancy
Routine Antenatal Care Versus Screening and Treatment of Malaria in Pregnancy in Rwanda
The main aim of this study is to test the primary hypothesis that the addition of intermittent screening and treatment of malaria in pregnant women (ISTp) who receive routine antenatal care (ANC) in health facilities in high…
- Trial name
- NCT03508349
- Testing
- IST
- Where
- 14 sites in Rwanda
- Volunteers
- 1,786 people, healthy volunteers welcome
- Sponsor
- Jhpiego
Malaria, Pregnancy
Pharmacokinetics of Mefloquine-Artesunate in Pregnant Women With Uncomplicated Plasmodium Falciparum Infection
Artemisinin-based combination therapies (ACTs) are now the treatment of choice for malaria in non-pregnant individuals living in areas with established chloroquine resistance; they have been shown to be both safe and highly…
- Trial name
- NCT01082718
- Testing
- Mefloquine Artesunate
- Sponsor
- Centers for Disease Control and Prevention