Clinical trials: Major Surgery
Hepatobiliary Disease, Pancreas Disease
Time to Post-operative Recovery of Serum Albumin as a Predictor of Outcome in Major Hepato Pancreato Biliary Surgeries
Hepatobiliary and Pancreatic surgery is associated with substantial risk of postoperative complications. Albumin is a negative acute phase protein.
- Conditions
- Hepatobiliary Disease, Pancreas Disease, Bile Duct Diseases
- Trial name
- NCT07263061
- Testing
- NO TREATMENT
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Postoperative Pain
Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery
The goal of this clinical trial] is to further explore the effectiveness and safety of oxelidine in the treatment of moderate to severe acute pain after orthopedic surgery.
- Trial name
- NCT06320041
- Testing
- Low dose oxelidine group, High dose oxelidine group, Hydromorphone group
- Where
- China
- Volunteers
- 162 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Ambulatory Surgery
Evaluation of the Impact of the SMART ANGEL ™ Device on Follow-up at Home Following Major or Intermediate Outpatient Surgery
The investigators hypothesize that by monitoring and analyzing physiological parameters (heart rate, blood pressure, saturation) and well-being (pain, nausea, vomiting, comfort) the SMART ANGEL ™ device improves the quality of…
- Trial name
- SMART ANGEL 2 (NCT04068584)
- Testing
- Smart Angel
- Where
- 12 sites in France
- Volunteers
- 1,260 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prevent Bleeding in Major Surgery
Wilate in Subjects With Von Willebrand Disease Who Undergo Surgery
Proportion of surgeries in which the primary endpoint (overall assessment) is classified as success.
- Trial name
- WONDERS (NCT01365546)
- Testing
- human VWF/FVIII concentrate
- Where
- 15 sites in United States, Bulgaria and 7 more
- Volunteers
- 30 people
- Sponsor
- Octapharma
Venous Thromboembolism, Thoracic Surgery
Incidence of Venous Thromboembolism in Patients Undergoing Major Esophageal Resection
The purpose of this study is to determine the incidence of post-operative venous thromboembolism (VTE) in patients undergoing major esophageal resection for malignancy.
- Conditions
- Venous Thromboembolism, Thoracic Surgery, Esophageal Cancer
- Trial name
- NCT03115541
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 187 people
- Sponsor
- McMaster University
Severe Aortic Valve Stenosis, Severe Mitral Valve Regurgitation
Post Spinal Hemodynamic Changes in Aortic Stenosis and Mitral Regurgitation by VIS Index and Echocardiography
This study will assess hemodynamic changes induced after spinal anesthesia by evaluating vasopressor inotropic requirements and variations in echocardiographic parameters in patients having severe aortic stenosis or severe mitral…
- Trial name
- NCT06156592
- Testing
- Cardiac valve replacement surgery under high spinal anesthesia combined with light general anesthesia
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Manitoba
Low Grade Glioma (LGG), High Grade Glioma (HGG)
Fluorescence Spectroscopy Guided Surgery
Intraoperative surgical fluorescence microscopy is a useful technique for the surgical resection of glioma. However the accuracy of this method is limited by its too low sensitivity.
- Trial name
- GLIOSPECT (NCT02473380)
- Testing
- Fluorescence spectroscopy guided surgery
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Hospices Civils de Lyon
Adults Waiting to Undergo Lung Cancer or Major Abdominal, Open or Video Assisted Cancer Surgery
Implementing Surgery School Prehabilitation Using Telehealth
The physiological challenge of major surgery has been likened to running a marathon. In both cases, preparation is critical. Yet, many patients undergo major surgery without understanding the potential consequences.
- Trial name
- STTARRS (NCT06631872)
- Testing
- Tele-prehabilitation education session: Surgery School, Individualised Inspiratory Muscle Training and Walking Program, Usual Care
- Where
- 9 sites in Australia
- Volunteers
- 515 people
- Sponsor
- University of Melbourne
Surgery, Cardiac Death
Endothelial Dysfunction and Non-cardiac Surgery
Endothelial dysfunction is a cardiovascular disease hallmark. After non-cardiac surgery, cardiovascular events correlate with surgical outcomes. Understanding the role of endothelial function in these events is crucial.
- Conditions
- Surgery, Cardiac Death, Stroke, Myocardial Injury
- Trial name
- NCT05778981
- Testing
- FMD - Troponin measurement
- Where
- Chile
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Chile
Anemia
Audit on Anemia Variation After Major Gynacological Surgery
The study aims to increase our understanding of variability in adherence to anaemia management guidelines and to assess the impact of anaemia management in clinical care following major gynaecological surgery
- Trial name
- NCT05280795
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Frail Elderly Syndrome
Frailty and Surgery
Frailty has been recently re-defined as a condition that is evident over time through an excess of vulnerability to stressors, with reduced ability to maintain or regain homeostasis after a destabilizing event, and occurrence of…
- Trial name
- NCT05594277
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Surgery
Assisted Fluid Management vs Manual GDFT
Goal-directed fluid therapy (GDFT) strategies based on cardiac output (CO) optimization have been shown to benefit moderate- to high-risk surgery patients and have recently been recommended by professional societies in the UK, in…
- Trial name
- NCT03141411
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Erasme University Hospital
Hepatic Insufficiency, Blood Coagulation Disorders
Major Liver Resection: Early Clotting Disorders and Functional Impairment.
The aim of this study is to evaluate early clotting disorders through thromboelastogram and anticoagulant proteins levels (maybe also endothelial markers) and liver function by indocyanine green clearance after major liver…
- Trial name
- NCT02813538
- Testing
- Indocyanine green clearance, Thromboelastometry
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Massive Transfusion, Bleeding During/Following Surgery
"ADE Fibrinogen/RBC" Ratio on Mortality and Outcome in Massive Transfusion Patients
Our study focuses on the transfusion of blood and blood products in cases of major bleeding, including massive transfusion scenarios where repeated doses of packed red blood cells (PRBC), fresh frozen plasma (FFP)…
- Trial name
- ADEFES (NCT06021184)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,679 people
- Sponsor
- Ankara City Hospital Bilkent
Obesity, Surgery
Laparoscopic Sleeve Gastrectomy in Severely Obese Adolescents: Effects on Metabolism
Severe obesity (SO), defined as BMI≥95th percentile, has increased worldwide among adolescents. American studies estimated that 1.3-2.8% of 12-19-year-old individuals have a BMI >40 kg/m2 or a BMI >35 kg/m2 with at least one…
- Trial name
- NCT02594514
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo General Hospital
Mitral Valve Regurgitation
Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System
The purpose of this study is to evaluate the safety and initial performance of the Neovasc Tiara Mitral Transcatheter Heart Valve with the Tiara Transapical Delivery System.
- Trial name
- TIARA-I (NCT02276547)
- Testing
- Mitral valve replacement
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 27 people
- Sponsor
- Shockwave Medical, Inc.
Acute Kidney Injury
Neutrophil Gelatinase-associated Lipocalin in Major Abdominal Surgery
Acute kidney injury (AKI) after major surgery is a well-known complication. The incidence of AKI after major surgery ranges from 13% to 50%.
- Trial name
- NCT05721638
- Testing
- Neutrophil gelatinase-associated lipocalin
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Antalya Training and Research Hospital
Intensive Care, Surgical
Can Point of Care Chest Ultrasound Predicts Pulmonary Complications After Major Surgery?
This study is done to estimate prevalence of the main detectable lung and cardiovascular complications by an ultrasound realized in room of post-interventional supervision at the patients whose duration of general anesthesia is…
- Trial name
- POCUSR (NCT02979652)
- Where
- France
- Volunteers
- 325 people
- Sponsor
- Hospital Nord
Surgery
Association Between Perioperative Platelet Function and Major Adverse Perioperative Events
This study will examine the degree of blood thinning (platelet function) in patients coming for non-cardiac surgery on antiplatelet agents using platelet function tests called thromboelastography (TEG) and platelet mapping assay…
- Trial name
- NCT00901030
- Testing
- Blood drawn
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
STEMI - ST-segment Elevation Myocardial Infarction
Metabolic Characteristics of Plasma OxPLs in STEMI Patients.
The goal of this observational study is to investigate the structural composition and metabolic characteristics of OxPLs in ST-segment elevation myocardial infarction(STEMI) patients.
- Trial name
- NCT07382700
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University