Clinical trials: Magnetic Resonance Spectroscopy
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease, which cases the death of neurons controlling the voluntary muscles.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Cortical Excitability
- Trial name
- NCT03664206
- Testing
- MRS, conventional TMS and treshold tracking TMS
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sándor Beniczky
Breast Diseases
The Study of Breast MRI Screening and Proton Magnetic Resonance Spectroscopy
To delineate if the chemical composition (lipid and water) in the presumably normal breast of the high risk women is different from those of the low risk group.
- Trial name
- NCT01749748
- Testing
- proton magnetic resonance spectroscopy
- Where
- Taiwan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Heroin Abuse, Opioid Use Disorder
Neuroimaging and CBD for Opioid Use Disorder
The investigators propose an imaging study to investigate the neurobiological effects of CBD (vs placebo) in participants with opioid use disorder who are maintained on methadone.
- Conditions
- Heroin Abuse, Opioid Use Disorder, Substance-Related Disorders, Opioid-Related Disorders
- Trial name
- NCT04567784
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yasmin Hurd
Insulin Resistance, NAFLD
Reversal of Lipid-Induced Insulin Resistance
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have…
- Trial name
- NCT02193295
- Testing
- Caloric Restriction
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yale University
Transcranial Direct Current Stimulation, Post-Concussion Syndrome
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome
Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases.
- Conditions
- Transcranial Direct Current Stimulation, Post-Concussion Syndrome, Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy
- Trial name
- NCT06376500
- Testing
- tDCS with cognitive training programme
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Glycogen Storage Disease IIIA
Acute Nutritional Ketosis in GSD IIIa
The investigators will study if acute nutritional ketosis in adult GSD IIIa patients can boost muscle mitochondrial function in vivo.
- Trial name
- NCT03011203
- Testing
- physical exercise
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- University Medical Center Groningen
HIV I Infection, HIV Associated Lipodystrophy
Neuroinflammation and Neurodegeneration in HIV-positive Subjects Switched and Initially Treated With INSTI
Since the HIV changed its course to the chronic disease, high incidence of metabolic syndrome both in HIV positive and negative subjects has become an issue.
- Conditions
- HIV I Infection, HIV Associated Lipodystrophy, Metabolic Syndrome, Aging
- Trial name
- NCT04887675
- Testing
- MRI
- Where
- Serbia
- Volunteers
- 120 people
- Sponsor
- University of Novi Sad
Prostate Cancer
Magnetic Resonance (MR) Spectroscopy in Localized Prostate Cancer
This study is designed to investigate whether filling the rectum with high density barium prior to a magnetic resonance spectroscopy (MRS)exam of the prostate improves the quality of the acquired spectrum.
- Trial name
- NCT00756392
- Testing
- 3T MR Spectroscopy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- AHS Cancer Control Alberta
Insulin Resistance
Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
The purpose of this study was to examine the pathophysiology of insulin resistance and the relation to the metabolic syndrome in humans.
- Trial name
- NCT02196051
- Testing
- one bout of 45 minutes exercise
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Parkinsons Disease (PD)
Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.
This study is designed l to evaluate the effects of GGC oral supplementation in early Parkinson's disease (PD) patients. The main objectives of the study are to evaluate: 1.
- Trial name
- PDGSH (NCT07064005)
- Testing
- Gamma- glutamylcysteine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Pravat Mandal
Diabetic Cardiomyopathy
Mechanisms Responsible for Cardiac and Skeletal Muscle Energetic Impairment in Diabetes
Diabetes increases the risk of heart failure. This is mainly due to a disease of the blood vessels supplying the heart muscle and/or high blood pressure, but abnormal metabolism may also contribute.
- Trial name
- DDCM (NCT00628056)
- Testing
- Perhexiline
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University Hospital Birmingham
Left Ventricular Dysfunction
Phosphorous Magnetic Resonance Spectroscopy of Heart
Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart.
- Trial name
- NCT01110395
- Testing
- MR Spectroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Glioblastoma, MRI Spectroscopy
Correlative Analysis Between Magnetic Resonance Spectroscopy (MRS) and Essential Clinicobiological Data in Glioblatoma Multiforme (GBM)
Glioblastoma multiforme (GBM) is the most common primary brain tumor, and it is well-known to be associated with a poor prognosis. MRI is the key medical technique for the diagnosis and the follow-up of GBM.
- Conditions
- Glioblastoma, MRI Spectroscopy, Tumor Microenvironment, Biomarkers / Blood
- Trial name
- GLIOMIT (NCT07211841)
- Testing
- MRS study, blood samples
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Memory Complaint, Alzheimer Disease
Study of Phosphorylated Metabolism Profile as Predictive Biomarker of Cognitive Decline in Memory Complaint.
Alzheimer disease is a frequent disease in the late ages that results in global alteration of cognitive functions. In which memory complaint can be isolated in the early stages.
- Conditions
- Memory Complaint, Alzheimer Disease, Phosphorylated Metabolism Profile, Magnetic Resonance Spectroscopy
- Trial name
- NCT03863041
- Testing
- Additional sequence performed during MRI scan
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Poitiers University Hospital
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Lung Cancer
Feasibility of Magnetic Resonance Spectroscopy in Lung Cancer
Lung cancer is commonly characterised either with a surgical procedure or by taking a tissue sample with a needle. Unfortunately, these invasive approaches may be unsafe in many patients with lung cancer, who often have…
- Trial name
- MRS (NCT02497586)
- Testing
- Magnetic resonance spectroscopy
- Volunteers
- 15 people
- Sponsor
- NHS Greater Glasgow and Clyde
Schizophrenia
A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in People With Schizophrenia
The NMDA receptor has been identified as having a role in substance use disorders as well as in schizophrenia. One example of the former is nicotine's effect on dopaminergic activity not only by increasing the release of dopamine…
- Trial name
- Sarc (NCT00538070)
- Testing
- Sarcosine
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer Diagnosis, Positron Emission Tomography
Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis
The application of FCH PET in breast cancer diagnosis has not been reported. We hypothesize that FCH reveals choline metabolic profiles of breast cancers, and shows the similar pathophysiological mechanism to choline on proton…
- Conditions
- Breast Cancer Diagnosis, Positron Emission Tomography, Magnetic Resonance Imaging
- Trial name
- NCT01956409
- Testing
- 18F-FCH, Magnevist
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Heart Failure, Heart Failure With Reduced Ejection Fraction
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study looks at the effects of weight loss in people who have heart failure with reduced ejection fraction (HFpEF) and are overweight or obese.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Obesity, Overweight
- Trial name
- SLEnDR (NCT05942287)
- Testing
- Diet intervention
- Where
- 2 sites in Jersey, United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Oxford
Postprandial IHL and IMCL Dynamics
Postprandial IHL and IMCL Measured With Proton Magnetic Resonance Spectroscopy
The major research objective is to assess the potential of Proton Magnetic Resonance Spectroscopy to follow Intrahepatic lipid and Intramyocellular lipid dynamics after a single meal.
- Trial name
- NCT01709643
- Testing
- High fat breakfast, HF breakfast with protein
- Where
- Netherlands
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center