Clinical trials: MCI
Alzheimer Disease, Mild Cognitive Impairment
Gamma Induction for Alzheimer's Disease
Alzheimer's Disease (AD) is characterized by amyloid-β (Aβ) plaque buildup and phosphorylated tau (p-tau) in the brain, as well as widespread neurodegeneration.
- Trial name
- NCT03880240
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment
CBD for Individuals at Risk for Alzheimer's Disease
This is a double-blind, randomized controlled trial designed to test the effects of cannabidiol (CBD) on validated biomarkers of Alzheimer's disease (AD) progression, and behavioral, neurocognitive, and clinical measures, with…
- Trial name
- NCT05822362
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- University of Colorado, Denver
Mild Cognitive Impairment
Modulation of Cognition and Brain Connectivity by Noninvasive Brain Stimulation in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease
Alzheimer's disease (AD) has a detrimental impact on cognitive functions. Based on pilot studies results in patients with neurodegenerative brain diseases the investigators aim for promoting the brain plasticity and improving…
- Trial name
- LUSTR (NCT04012346)
- Testing
- Transcranial magnetic stimulation
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Masaryk University
Alzheimer Disease, Progressive Posterior Cortical Dysfunction (PPCD)
F 18 T807 Tau PET Imaging of Progressive Posterior Cortical Dysfunction (IND 123119, Protocol E)
This project will collect quantitative pilot data that will allow the characterization of uptake and binding of 18F-AV-1451 (also known as F 18 T807), a novel tau imaging compound, in individuals with Progressive Posterior…
- Trial name
- Protocol E (NCT02414282)
- Testing
- F 18 T807
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tammie L. S. Benzinger, MD, PhD
Mild Cognitive Impairment, Randomized Controlled Trial
Cognitive Stimulation in Older With Mild Cognitive Impairment
The participants who carry out our program of cognitive stimulation, deteriorate at a cognitive level more slowly and can improve their score of the Spanish version of 35 points of Mini-mental State of Folstein; Mini-exam…
- Trial name
- Cognitive (NCT03831061)
- Testing
- Cognitive stimulation
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Obstructive Sleep Apnea of Adult, Mild Cognitive Impairment
The Relationship Between Obstructive Sleep Apnea and Alzheimer's Disease: Evidence and Effectiveness
The research plan to enroll 15 simple snoring patients (apnea/hypopnea <5, control group), 30 severe OSA patients (apnea/hypopnea >30, treatment group), and 15 mild cognitive impairment patients (comparative group).
- Trial name
- OSA (NCT05433883)
- Testing
- sleep surgery
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Repetitive Transcranial Magnetic Stimulation (rTMS), Functional Magnetic Resonance Imaging
Repeated Transcranial Magnetic Stimulation Relieves Maternal Care Impairment
Objective: To evaluate the overall efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of maternal care impairment (MCI) and to explore the central mechanism of rTMS for MCI.
- Conditions
- Repetitive Transcranial Magnetic Stimulation (rTMS), Functional Magnetic Resonance Imaging, Maternal Care Patterns
- Trial name
- NCT06743724
- Testing
- rTMS group
- Where
- 2 sites in China
- Volunteers
- 45 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Healthy Volunteers
A Study of LY2886721 in Healthy Participants
The purpose of this phase I study in healthy participants will be to evaluate the safety and tolerability of LY2886721 single and multiple doses, to evaluate how the body handles the drug, and to evaluate the drug's effect on the…
- Trial name
- NCT01534273
- Testing
- LY2886721
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Alzheimer Disease, Mild Cognitive Impairment
A Longitudinal Evaluation of a Radiotracer for Use in Tau Tracking
This is a longitudinal, observational study evaluating the imaging characteristics of the tau PET radioligand [18F]MK-6240 in Alzheimer's disease (AD), Mild Cognitive Impairment (MCI) and Healthy Volunteer (HV) subjects.
- Trial name
- NCT03919669
- Testing
- All Subjects
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cognitive Decline
Analysis of Inflammatory Predictors and Gene Expression in Patients With Mild Cognitive Impairment
A randomized, double-blind, placebo-controlled clinical trial will be conducted, using data from participants who met the diagnostic criteria for mild cognitive impairment and who participated in a primary clinical trial that…
- Trial name
- NCT04934423
- Testing
- Direct Current Transcranial Stimulation - tDCS
- Volunteers
- 40 people
- Sponsor
- Federal University of Paraíba
Parkinson's Disease, Mild Cognitive Impairment
Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease
The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor…
- Trial name
- NCT05968703
- Testing
- Combined STN+NBM DBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Helen M. Bronte-Stewart
Mild Cognitive Impairment
Efficacy and Safety of 1612 Capsules in aMnestic Mild Cognitive Impairment
This study is a 52-weeks, multicenter, randomized, double-blind, placebo controlled, parallel trial which will be carried out in 15 centers around China.
- Trial name
- NCT02982642
- Testing
- 1612 capsule
- Where
- China
- Sponsor
- Dongzhimen Hospital, Beijing
Mild Cognitive Impairment
EVASION: Effect of VisuAl Stimulation on attentION
The main objective is to compare changes in information processing speed after 30 days of intervention in participants with a dysexecutive mild cognitive impairment (MCI) and receiving either cognitive stimulation by adapted…
- Trial name
- EVASION (NCT05791994)
- Testing
- Visual cognitive stimulation exercises, Broadcast of a television program
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Angers
Mild Cognitive Impairment in Middle-aged Adults
Deafness and Cognition in Middle-aged Adults
A mild cognitive impairment was observed in 50% of cochlear implant candidates aged 65 years and over, compared to 5-19% in general population. No studies analysed cognition in patients younger than 65 years.
- Trial name
- SURDICOG (NCT05149742)
- Testing
- Cognitive and audiometry evaluation
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild Cognitive Impairment
Efficacy and Safety of T-817MA in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD
Primary objective is to evaluate the neuroprotective effect of T-817MA on Tau protein phosphorylated at threonine 181 (p-tau 181) in cerebrospinal fluid (CSF) compared with placebo in patients with a diagnosis of MCI due to AD or…
- Trial name
- NCT04191486
- Testing
- T-817MA
- Where
- 37 sites in Czechia, Germany and 5 more
- Volunteers
- 221 people
- Sponsor
- FUJIFILM Toyama Chemical Co., Ltd.
Advanced Care Planning
A Portal-based Advance Care Planning Intervention Among Community-Dwelling Persons Living With Cognitive Impairment
The purpose of this research is to examine the feasibility of using a patient portal based advance care planning (ACP) tool to improve ACP discussions and documentation in persons living with cognitive impairment in outpatient…
- Trial name
- Portal-Voice (NCT06509373)
- Testing
- Advance Care Planning Tool - ACPVoice, Standard of Care for Advance Care Planning
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Parkinson's Disease, Dementia
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Background: About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases.
- Conditions
- Parkinson's Disease, Dementia, Alzheimer's Disease, ALS
- Trial name
- NCT04396873
- Testing
- 11C-MC1, 11C-PS13, 18f-florbetaben
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Mild Cognitive Impairment, Alzheimer Disease
Light, Metabolic Syndrome and Alzheimer's Disease - Aim 2
To test the long term effect of a light treatment on cognition, sleep and metabolism in patients with Mild cognitive impairment (MCI) or mild Alzheimer's disease or related dementia (ADRD).
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Type2 Diabetes
- Trial name
- NCT03933696
- Testing
- Tailored Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Cognitive Impairment
Effects of Thai Dance With Twenty-five Squares in Elderly With Mild Cognitive Impairment
The objective of this study was to determine the effects of Thai dance with twenty-five squares on cerebrovascular and cognitive function in elderly with mild cognitive impairment
- Trial name
- NCT06236646
- Testing
- Thai dance with twenty-five squares (TDT), Control (CON)
- Where
- 2 sites in Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Alzheimer Disease
CBT for African Americans With Cognitive Impairment
The aim of the study is to test the feasibility and acceptability of a six-month cognitive-behavioral therapy (CBT) program (group based and phone-based) compared with usual care, and to determine if the intervention can improve…
- Trial name
- NCT03384069
- Testing
- Group-based Cognitive Behavioral Therapy (CBT), Phone-based Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Emory University