Clinical trials: Lymph Node Cancer
Breast Cancer
SWOG-8814 Tamoxifen With or Without Combination Chemotherapy in Postmenopausal Women Who Have Undergone Surgery for Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the use of estrogen by the tumor cells.
- Trial name
- NCT00929591
- Testing
- cyclophosphamide, doxorubicin hydrochloride, endocrine therapy
- Volunteers
- 1,558 people
- Sponsor
- SWOG Cancer Research Network
Carcinoma, Non-Small Cell Lung
Endobronchial Ultrasound- Transbronchial Needle Aspiration (EBUS-TBNA) Versus Mediastinoscopy for Mediastinal Lymph Node Staging of Non-small Cell Lung Cancer (NSCLC)
Accurate staging of the mediastinum is essential to evaluate prognosis in non-small cell lung cancer and to devise an appropriate treatment plan.
- Trial name
- NCT01079520
- Testing
- Endobronchial ultrasound (EBUS), Mediastinoscopy
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Samsung Medical Center
Sentinel Lymph Node, Colorectal Cancer
Sentinel Lymph Node (SLN) in Colorectal Carcinoma (CRC) With a Near-infrared (NIR)-Dye
The sentinel lymph node (SLN) procedure is a standard staging technique in several types of cancer. One of the major problems of SLN mapping in colorectal cancer is the lack of an optimal dye and technique for identification of…
- Conditions
- Sentinel Lymph Node, Colorectal Cancer, Metastasis
- Trial name
- NCT02122523
- Testing
- Near-Infrared (NIR) dye Indocyanin Green (ICG)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Amsterdam UMC, location VUmc
Lung Cancer
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT)
It is reported that more than 90,000 patients died of lung cancer and more than 20% of them were older than 80 years in North America.
- Trial name
- NCT01786590
- Testing
- EBUS-TBNA
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Non-Small Cell Lung Cancer
Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment
This study will investigate the role of sampling suspicious chest lymph nodes with a procedure called endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA) or transesophageal ultrasound-guided fine…
- Trial name
- NCT04852588
- Testing
- Endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TFNA), Transesophageal ultrasound-guided fine needle aspiration (EUS-FNA)
- Where
- 2 sites in Canada
- Volunteers
- 29 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hepatocellular Carcinoma, Radiotherapy, Sorafenib
Phase II Study of Concurrent Sorafenib and Intensity-modulated Radiotherapy (IMRT) for Advanced Hepatocellular Carcinoma
This is a single-arm phase II clinical trial to investigate the efficacy and toxicity of concurrent sorafenib and intensity-modulated radiotherapy (IMRT) for advanced hepatocellular carcinoma with portal vein or hepatic vein…
- Trial name
- SIRAHCC (NCT03535259)
- Testing
- concurrent sorafenib and IMRT, followed sorafenib maintenance
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Squamous Cell Carcinoma of the Head and Neck, Carcinoma of the Head and Neck
Panitumumab-IRDye800 and 89Zr-Panitumumab in Identifying Metastatic Lymph Nodes in Patients With Squamous Cell Head and Neck Cancer
This study evaluates how well panitumumab-IRDye800 and 89Zr-panitumumab work in identifying cancer that has spread to the lymph nodes in patients with squamous cell head and neck cancer.
- Trial name
- NCT03733210
- Testing
- Panitumumab-IRDye800, 89-Zirconium (Zr-89) Panitumumab, Pinpoint IR IR9000 fluorescence imaging system (FIS)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Andrei Iagaru
Breast Cancer
A French Observational Study of Indocyanine Green for Patients With Breast Cancer Having a Sentinel Lymph Node Biopsy.
This prospective, observational study will evaluate the patient-based sentinel lymph node detection rate when using the Infracyanine® (indocyanine green) dye technique in patients undergoing surgery for breast cancer.
- Trial name
- OASIS (NCT06024213)
- Testing
- Sentinel lymph node identification, indocyanine green, methylene blue
- Where
- 6 sites in France
- Volunteers
- 101 people
- Sponsor
- BTG International Inc.
Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate
RYZ711 Diagnostic Platform Study
This is a Phase 1/2 multicenter, multi-cohort imaging study to evaluate the safety, tolerability, and diagnostic performance of RYZ711 positron emission tomography/computed tomography (PET/CT) in men with histologically confirmed…
- Conditions
- Prostate Cancer (Adenocarcinoma), Adenocarcinoma of the Prostate, Metastatic Castration-resistant Prostate Cancer (mCRPC), Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
- Trial name
- NCT07862582
- Testing
- RYZ711, PSMA PET/CT
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- RayzeBio, Inc.
Prostate Cancer
Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells.
- Trial name
- NCT00567580
- Testing
- PBRT, PLNRT, AA
- Where
- 460 sites in United States, Canada and 2 more
- Volunteers
- 1,792 people
- Sponsor
- Radiation Therapy Oncology Group
Esophageal Squamous Cell Carcinoma (ESCC)
Postoperative Radiotherapy and Lymph Node Dissection After Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma
This is a multicenter, retrospective observational study using existing medical records of patients with esophageal squamous cell carcinoma who received at least two cycles of neoadjuvant immunochemotherapy followed by curative…
- Trial name
- NCT07705412
- Testing
- Postoperative Radiotherapy, Lymph Node Dissection
- Where
- China
- Volunteers
- 465 people
- Sponsor
- Tongji Hospital
Breast Neoplasms
Robotic-Assisted vs. Endoscopic-Assisted Sentinel Lymph Node Biopsy in Breast Cancer
This is a retrospective observational study comparing the accuracy and safety of robotic-assisted versus endoscopic-assisted sentinel lymph node biopsy (SLNB) in patients with breast cancer.
- Trial name
- NCT07741734
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Nasopharyngeal Carcinoma
Combining MRI and CEUS to Diagnose Small Cervical Lymph Node Metastases in NPC Patients
This is a single-center diagnostic accuracy study, with the purpose to define the criteria to diagnose small cervical lymph node metastases in patients with nasopharyngeal carcinoma by combining MRI scanning and contrast-enhanced…
- Trial name
- NPC-LN (NCT05389306)
- Testing
- MRI Scanning, Contrast-Enhanced Ultrasonography, Ultrasound-guided Lymph Node Aspiration
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Sun Yat-sen University
Lung Cancer (NSCLC), Lymph Node Dissection
Selective Lymph Node Resection for Invasive Non-small Cell Lung Cancer With the CTR of 0.5-1 and the Diameter of ≤ 2 cm
The study investigated the efficacy and safety of a selective lymph node strategy (no lower mediastinal lymph node dissection for upper lobe tumors and no upper mediastinal lymph node dissection for lower lobe tumors) in patients…
- Trial name
- NCT06634979
- Testing
- Selective lymph node dissection
- Where
- China
- Volunteers
- 684 people
- Sponsor
- Fudan University
Breast Neoplasms
Omitting Completion Axillary Treatment in Sentinel Node Positive Breast Cancer Patients Undergoing a Mastectomy
STUDY AIM To decrease the number of breast cancer patients receiving overtreatment of the axilla, in order to positively influence the axillary morbidity rate and quality of life.
- Trial name
- NCT02112682
- Testing
- Completion axillary treatment
- Where
- 31 sites in Netherlands
- Volunteers
- 52 people
- Sponsor
- Maastricht University Medical Center
HER2-positive Breast Cancer
A Randomized, Open-label, Multi-center Phase III Study Comparing the Efficacy of Oral Chemotherapy Combined With Trastuzumab Versus Paclitaxel Combined With Trastuzumab in the Adjuvant Treatment of HER2-positive, Lymph Node-negative Early Breast Cancer Patients(ORCHID-PLUS)
Although there is a certain risk of recurrence of HER2-positive small tumors, the overall prognosis is relatively good. In order to further reduce the toxicity and side effects of treatment and explore the best strategy for…
- Trial name
- NCT06992882
- Testing
- Capecitabine, Paclitaxel
- Where
- China
- Volunteers
- 2,306 people
- Sponsor
- Fudan University
Urologic Cancer, Urologic Neoplasms
A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest
This research study is a pilot clinical trial, which hypothesizes that the combination of electromagnetic tracking in conjunction with laparoscope imaging and ultrasound probe imaging will aid in reducing the complexity of both…
- Conditions
- Urologic Cancer, Urologic Neoplasms, Bladder Cancer, Prostate Cancer
- Trial name
- NCT05899361
- Testing
- Electromagnetic Guided Laparoscopy, Ultrasound
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Porocarcinoma, Sentinel Lymph Node
Sentinel Lymph Node Biopsy in Porocarcinoma
Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both.
- Trial name
- NCT03647631
- Testing
- sentinel lymph node biopsy
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Ospedale Policlinico San Martino
Stage I Endometrial Carcinoma, Stage II Endometrial Carcinoma
Lymph Node Mapping in Patients With Newly Diagnosed Endometrial Cancer Undergoing Surgery
This clinical trial studies lymph node mapping in patients with newly diagnosed endometrial cancer undergoing surgery. Lymph node mapping may help in planning surgery to remove endometrial cancer and affected lymph nodes.
- Conditions
- Stage I Endometrial Carcinoma, Stage II Endometrial Carcinoma, Stage III Endometrial Carcinoma, Stage IV Endometrial Carcinoma
- Trial name
- NCT01939028
- Testing
- lymph node mapping, sentinel lymph node biopsy, isosulfan blue
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Neoplasms
A Prospective Clinical Study for Laparoscopic D3 Dissection With Preservation of Left Colic Artery in Rectal Cancer
During surgery for rectal cancer, there is considerable controversy regarding the optimal level of ligation of the inferior mesenteric artery.
- Trial name
- NCT02753465
- Testing
- left colic artery, High ligation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University