Clinical trials: Lung Recruitment
Abdominal Cancer
Individualized Lung Recruitment Maneuver Guide by Pulse-oximetry in Anesthetized Patients
General anesthesia and mechanical ventilation promotes atelectasis and airway closure. The open-lung approach (OLA) strategy restores the functional residual capacity.
- Trial name
- NCT02912819
- Testing
- Open-lung approach
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Mechanical Ventilation
Sigh in Pressure Support Ventilation to Detect Respiratory System Compliance and Lung Recruitability
The goal of this physiological study is to determine whether ventilator-delivered sigh breaths during pressure support ventilation (PSV) provide a reliable bedside index of lung recruitability and can guide PEEP optimization.The…
- Trial name
- NCT07172061
- Testing
- PSV + sigh (Clinical PEEP and Clinical PEEP + 3 cmH₂O)
- Where
- 2 sites in Italy
- Volunteers
- 110 people
- Sponsor
- AUSL Romagna Rimini
Respiratory Distress Syndrome, Newborn
Role of Lung Ultrasound In Assessment Of Recruitment Maneuvers In Ventilated Preterms With Respiratory Distress Syndrome and Its Correlation With Tracheal IL-6 Level
This work is designed to: 1. Evaluate the efficacy of lung ultrasonography in detecting opening and closing lung pressures in ventilated preterm neonates with respiratory distress syndrome. 2.
- Trial name
- NCT04107090
- Testing
- lung recruitment maneuver, tracheal IL-6 level, US guided lung recruitment maneuver
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Ain Shams University
Lung Cancer, Patient Engagement
Improving Access to Lung Cancer Clinical Trials
There are ~85,000 lung cancer patients (LCPs) in the UK; yet only around 8% were recruited into clinical trials in 2021/22. LCPs need opportunities to take part in clinical trials to access new treatments, increasing their…
- Conditions
- Lung Cancer, Patient Engagement, Research, Communication, Nurse-Patient Relations
- Trial name
- Lung I-ACT (NCT05780164)
- Testing
- Research readiness tool
- Where
- United Kingdom
- Volunteers
- 109 people
- Sponsor
- Oxford Brookes University
Hypoxemia
Recruitment Maneuver After Intubation
The purpose of this study is to evaluate the safety and efficacy of a recruitment maneuver immediately after intubation in hypoxemic patients.
- Trial name
- NCT01014299
- Testing
- Recruitment maneuver
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
ARDS, Human, Ventilation Therapy; Complications
Assessment of the Hemodynamic Effects of PEEP According to Alveolar Recruitment During the ARDS
The corner stone of the treatment of ARDS is mechanical ventilation with high levels of positive end-expiratory pressure, also called PEEP. A high level of PEEP is recommended and frequently used.
- Conditions
- ARDS, Human, Ventilation Therapy; Complications, Alveolar; Disorder
- Trial name
- NCT05524558
- Testing
- Pulmonary artery catheter, Esophagal pressure
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Bicetre Hospital
COPD Exacerbation
Once Daily Long-Acting Muscarinic Antagonists Administered in the Evening for Prevention of Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization or Death from Any Cause
To examine, among once-daily LAMA using COPD patients, whether evening administration of LAMA is superior with respect to the incidence of hospitalization requiring AECOPD or death from all causes than the more conventional…
- Trial name
- NCT05563675
- Testing
- Long acting muscarinic antagonists (LAMAs) in the evening
- Where
- Denmark
- Volunteers
- 10,011 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Atelectasis
Role of Lung Ultrasound Imaging in the Comparison of Two Mechanical Ventilation Strategies During Laparotomy
The use of positive end-expiratory pressure (PEEP) and recruitment maneuvers during laparotomy will limit the development of atelectasis and therefore improve the aeration score.
- Trial name
- NCT02055807
- Testing
- PEEP and recruitment maneuvers, ZEEP (no PEEP nor recruitment maneuver)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Thoracic, Diseases
The Effect of Two Airway Interventions, During One Lung Ventilation, on Blood Oxygen Content
Patients requiring one lung ventilation (OLV) for open thoracic surgery will be ventilated (breathing performed by a breathing machine) during anesthesia using a lung protective ventilation strategy (small breath volumes at…
- Trial name
- NCT01495936
- Testing
- RM + Positive End Expiratory Pressure, Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia
High Frequency Oscillatory Ventilation Combined With Intermittent Sigh Breaths: Effects on Blood Oxygenation and Stability of Oxygenation
Background: Ventilator induced lung injury (VILI) remains a problem in neonatology. High frequency oscillatory ventilation (HFOV) provides effective gas exchange with minimal pressure fluctuation around a continuous distending…
- Conditions
- Respiratory Distress Syndrome, Newborn, Bronchopulmonary Dysplasia, Ventilator Induced Lung Injury
- Trial name
- NCT01959009
- Testing
- HFOV combined with sigh breaths
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs)
EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery
This study is a prospective, single-center, single-blind, randomized controlled clinical trial. Patients scheduled for laparoscopic bariatric surgery will be selected and randomly assigned to either the EIT-guided individualized…
- Conditions
- Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs), Recruitment, Mechanical Ventilation Complication
- Trial name
- EIT (NCT07207772)
- Testing
- Group P-eit, Group P-8
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Jianbo Wu
Covid-19, Substance Use
Leveraging Social Networks to Increase COVID-19 Testing Uptake
This two-year project will adapt and conduct a trial examining the ability of two recruitment strategies, chain-referral and credible messenger, to reach those who use opioids and other substances in order to increase their…
- Conditions
- Covid-19, Substance Use, Opioid Use
- Trial name
- NCT04873401
- Testing
- Chain-referral, Credible Messenger
- Where
- United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Pulmonary Atelectasis, Postoperative
Effect of Different Inspired Oxygen Concentrations on Intraoperative Recruitment Outcomes in Patients Undergoing Abdominal Surgery
This study intends to evaluate the effect of different inhaled oxygen concentrations on the effect of lung recruitment in patients undergoing abdominal surgery.
- Trial name
- NCT06746181
- Testing
- Fraction of inspiration O2(FiO2)
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Northern Jiangsu People's Hospital
Major Abdominal Surgery, Atelectasis
Optimal Interval for Periodic Alveolar Recruitment Maneuvers Achieving 90% Lung Re-expansion During Intraoperative Ventilation
This study aims to determine the optimal interval for periodic alveolar recruitment maneuvers (PARM) that can achieve effective lung re-expansion in 90% of patients undergoing intraoperative mechanical ventilation during…
- Conditions
- Major Abdominal Surgery, Atelectasis, Lung-protective Ventilation, Lung Ultrasound Score
- Trial name
- NCT07239557
- Testing
- Different interval of PARM
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Collapsed Lung
Sonographic Assessment of Postural Lung Recruitment in Pediatric Patients Under General Anesthesia
Anesthesia-induced atelectasis is a well-known entity observed in approximately 68-100% of pediatric patients undergoing general anesthesia.
- Trial name
- NCT03141515
- Testing
- Lung ultrasound
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Pain, Postoperative, Postoperative Nausea and Vomiting
Effect of Pulmonary Recruitment Maneuver (PRM) on Pain and Nausea After Laparoscopic Cholecystectomy
This prospective, blinded, randomized clinical trial investigates the effect on postoperative pain and nausea, when performing a ventilator-piloted PRM at the end of a laparoscopic cholecystectomy.
- Trial name
- NCT03026543
- Testing
- Pulmonary Recruitment Maneuver, Laparoscopic cholecystectomy, Ventilator
- Where
- Sweden
- Volunteers
- 260 people
- Sponsor
- Region Östergötland
ARDS, Respiratory Failure
PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT
In a population of ARDS patients, we explore the influence of different PEEP levels on regional ventilation distribution, ventilation homogeneity, and the center of ventilation, optimal PEEP and lung recruitment potential as well…
- Trial name
- NCT06594601
- Testing
- lung recruitment potential assessed by 3D EIT, PEEP titration by 3D eit
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Pain, Postoperative, Postoperative Nausea and Vomiting
Effect of Pulmonary Recruitment Maneuver (PRM) on Pain and Nausea After Laparoscopic Bariatric Surgery
The purpose of this prospective, blinded, randomized clinical trial is to investigate whether a ventilator-piloted PRM at the end of laparoscopic bariatric surgery could reduce overall postoperative pain and nausea.
- Trial name
- NCT03026530
- Testing
- Pulmonary recruitment maneuver, Laparoscopic bariatric surgery, Ventilator
- Volunteers
- 200 people
- Sponsor
- Region Östergötland
High-flow Nasal Cannula, Electrical Impedance Tomography
Effects of High-Flow Nasal Cannula Therapy Assessed by Electrical Impedance Tomography
This study aimed to determine the effects of HFNC therapy on lung recruitment and lung strain change assessed by electrical impedance tomography (EIT)
- Trial name
- NCT04245241
- Testing
- High-flow nasal cannula (HFNC)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
ICU Patients, Healthy Lung
Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Respiratory Distress Syndrome
PEEP titration is a recommended during invasive mechanical ventilation of ICU patients. However, little is known about the right way to conduct this titration.
- Conditions
- ICU Patients, Healthy Lung, Positive End-Expiratory Pressure, ARDS
- Trial name
- PEEP-Réa (NCT04503876)
- Testing
- Increasing PEEP setting, Decreasing PEEP setting
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand