Clinical trials: Lung Nodules
Lung Nodule, Lung Cancer
Biobank for the Identification of Biomarkers in Lung Cancer (BIRD, Biomarkers in Respiratory Disease)
The BIRD biobank aims at collecting clinical and biological data from patients suffering from a chronic respiratory disease. The lung cancer subpopulation will be divided into two cohorts to identify biomarkers of cancer.
- Trial name
- BIRD-NK (NCT06054854)
- Testing
- Extra blood sampling, Non-invasive or leftover samples or medical waste
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Toulouse
Pulmonary Nodules
Diagnostic and Monitoring Significance of ctDNA Methylation Analysis by NGS in Benign and Malignant Pulmonary Nodules
AnchorDx is using circulating tumor DNA (ctDNA) methylation analysis by next-generation sequencing (NGS) to develop a blood-based assay for differentiating benign and malignant pulmonary nodules early.
- Trial name
- NCT03651986
- Testing
- ctDNA methylation analysis by NGS
- Where
- 23 sites in China
- Volunteers
- 10,560 people, healthy volunteers welcome
- Sponsor
- AnchorDx Medical Co., Ltd.
Lung Cancer, Pulmonary Nodule, Multiple
Lung Nodule Imaging Biobank for Radiomics and AI Research
This study will collect retrospective CT scan images and clinical data from participants with incidental lung nodules seen in hospitals across London.
- Conditions
- Lung Cancer, Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary, Lung Neoplasms
- Trial name
- LIBRA (NCT04270799)
- Testing
- Machine Learning Classification
- Where
- 5 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Lung Diseases, Interstitial, Pulmonary Nodule, Solitary
Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection
After performing VATS pulmonary wedge resections, a chest tube is routinely left in the pleural cavity to drain possible air leaks and fluid accumulations.
- Trial name
- NOTUBE (NCT00841750)
- Testing
- Do not leave a chest tube in the pleural cavity., Do leave a chest tube in the pleural cavity.
- Where
- 3 sites in Colombia
- Volunteers
- 100 people
- Sponsor
- Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle
High-risk Lung Nodules
Immunoprevention for High-risk Lung Lesions
The main purpose of this study is to assess nadunolimab as an immunoprevention strategy for high-risk lung nodules in participants who are current or former tobacco smokers. The study may last up to 5 years for each participant.
- Trial name
- NCT07284485
- Testing
- Nadunolimab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Robert Samstein
Multiple Pulmonary Nodules
Neoadjuvant Immunotherapy in Early Stage Non-small-cell Lung Cancer Presenting as Synchronous Ground-glass Nodules
Neoadjuvant Immunotherapy in Early Stage Non-small-cell Lung Cancer Presenting as Synchronous Ground-glass Nodules: a pilot study
- Trial name
- NCT04047186
- Testing
- Tislelizumab Injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- XiangNing Fu
Lung Cancer (Diagnosis), Lung Nodule
A Randomized Controlled Trial Comparing Percutaneous CT-Guided Biopsy and Shape-Sensing Robotic-Assisted Bronchoscopy
The ENCOMPASS study is a post-market, multicenter, randomized controlled trial comparing two established approaches for obtaining a biopsy of small pulmonary nodules (≤2 cm): CT-guided percutaneous lung nodule biopsy and…
- Trial name
- ENCOMPASS (NCT07761351)
- Testing
- Shape-Sensing Robotic-Assisted Bronchoscopy with Cone-Beam CT (ssRAB with CBCT), CT-guided percutaneous lung nodule biopsy
- Where
- 3 sites in Germany, Switzerland and 1 more
- Volunteers
- 550 people
- Sponsor
- Intuitive Surgical
Diagnosis, Complication Rate
The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in The Pulmonary Periphral Nodule
Transbronchial cryobiopsy under the guidance of endobronchial ultrasound is performed in patients with pulmonary peripheral nodule, and assess the diagnostic yield and safety.
- Trial name
- NCT04661956
- Testing
- Transbronchial cryobiopsy/Transbronchial lung biopsy (forcep)
- Where
- 24 sites in China
- Volunteers
- 300 people
- Sponsor
- ShiYue Li
Pulmonary Nodule, Solitary, Whole-genome Methylation Sequencing
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned.
- Trial name
- NCT05415670
- Testing
- Whole-genome Methylation Sequencing(GM-seq)
- Where
- 2 sites in China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Geneplus-Beijing Co. Ltd.
Lung Nodules
Bronchoscopic Navigation Robot-guided Dye Marking-assisted Thoracoscopic Pulmonary Nodule Resection
With the widespread use of low-dose spiral CT screening for the lungs, an increasing number of small nodules are being detected, and surgical resection is the preferred method for clinical intervention of pulmonary nodules.
- Trial name
- NCT06821451
- Testing
- Bronchoscopic navigation robot, Conventional electromagnetic navigation bronchoscope
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Ruijin Hospital
Pulmonary Nodule Cm
Sedation of Remazolam Combined With Afentanil in Non-intubated Thoracoscopic Pulmonary Surgery
Non-intubated Thoracoscopic surgery (NITS) is a newly emerging minimally invasive surgical technique in recent years . Compared with traditional intubation general anesthesia, it has the advantages of less trauma, faster recovery…
- Trial name
- R-A NITS (NCT06810843)
- Testing
- Remazolam combined with afentanil for non-intubated thoracoscopic surgery, Propofol combined with afentanil in non-intubated thoracoscopic surgery
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Qianfoshan Hospital
Lung Cancer, Smoking
Pulmonary Nodule Detection: Comparison of an Ultra Low Dose vs Standard Scan.
Lung cancer screening programs are still discussed in Europe today, and one of the concern is radiation due to iterative CT. The aim of this monocentric, prospective, non randomized study is to compare an ultra low dose chest CT…
- Conditions
- Lung Cancer, Smoking, Radiation Exposure
- Trial name
- npUBD (NCT03305978)
- Testing
- Ultra low dose chest CT, Low dose chest CT
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Nodules, Lung Neoplasms
Deep Learning Time-Series Prediction of Long-Term Growth Patterns of Pulmonary Ground-Glass Nodules Using Serial CT
Pulmonary ground-glass nodules (GGNs) are commonly found on chest CT scans. Some stay stable for years, while others slowly or rapidly turn into lung cancer.
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Adenocarcinoma of Lung
- Trial name
- GGN-Trajectory (NCT07647692)
- Testing
- Serial Thin-Slice Chest CT
- Where
- China
- Volunteers
- 4,750 people
- Sponsor
- Peking University People's Hospital
Lung Cancer
Amino Acid Tracer (FACBC) Positron Emission Tomography for Lung Nodule
This study will look at how the [18]FACBC goes into the lung nodules. This will hopefully lead to the development of better imaging techniques to look at lung nodules.
- Trial name
- SPN (NCT01502670)
- Testing
- 18F-FACBC Radiotracer
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Pain, Pulmonary Nodules
Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use…
- Conditions
- Pain, Pulmonary Nodules, Oxycodone
- Trial name
- NCT07484867
- Testing
- oxycodone
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Pulmonary Lesions, Pulmonary Nodules
Ultrathin Bronchoscope and Radial Endobronchial Ultrasound (R-EBUS) With Fluoroscopy Versus Standard Fiberoptic Bronchoscopy (FB) (P00029233 )
The purpose of this study is to compare the yield of two methods for obtaining a lung tissue sample: Procedure #1: standard fiberoptic bronchoscopy (FB) with fluoroscopy, and Procedure #2: ultrathin bronchoscope procedure with…
- Conditions
- Pulmonary Lesions, Pulmonary Nodules, Pulmonary Mass
- Trial name
- NCT02146131
- Testing
- Standard FB with fluoroscopy, R-EBUS with ultrathin bronchoscope
- Where
- 5 sites in United States
- Volunteers
- 339 people
- Sponsor
- Medical University of South Carolina
Lung Neoplasms, Early Diagnosis
Diagnosis of Individuals With Pulmonary Nodules by Different Bronchoscopy Combination
This study evaluates the value of different bronchoscopy combination for diagnosing peripheral pulmonary lesions suspected to be cancer.
- Conditions
- Lung Neoplasms, Early Diagnosis, Bronchoscopy
- Trial name
- NCT02268162
- Testing
- guiding equipments
- Where
- China
- Volunteers
- 3,228 people
- Sponsor
- Tang-Du Hospital
Peripheral Pulmonary Nodules, Ablation Techniques
Diagnosis and Treatment of Lung Lesions
To evaluate the safety and feasibility of a single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB).
- Trial name
- NCT07642986
- Testing
- A single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Jisong Zhang
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
IDEAL: Artificial Intelligence and Big Data for Early Lung Cancer Diagnosis Study
This study aims to test the use of novel CT image analysis techniques to enable a better characterisation of small pulmonary nodules.
- Conditions
- Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- IDEAL (NCT03753724)
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,293 people
- Sponsor
- University of Oxford
Lung Nodules
Pre-Emptive Parecoxib Sodium for Pain Control During CT-Guided Lung Nodule Localization
Before undergoing minimally invasive lung surgery, patients with small lung nodules often need a procedure called "CT-guided hook wire localization." This involves using a CT scanner to help doctors place a tiny wire in the lung…
- Trial name
- PEARL (NCT07675473)
- Testing
- PARECOXIB SODIUM, 0.9 % Normal Saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Long Jiang