Clinical trials: Lung Mechanics
Cholelithiases, Laparoscopic Cholecystectomy
"Comparison of of Volume-Controlled Ventilation and Pressure-Controlled Ventilation Modes in Laparoscopic Cholecystectomy"
This randomized controlled trial compares volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) in adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia.
- Conditions
- Cholelithiases, Laparoscopic Cholecystectomy, General Anaesthesia
- Trial name
- VCV VS PCV (NCT07709039)
- Testing
- Volume-Controlled Ventilation, Pressure Controlled Ventilation
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mehreen Mirza
Respiratory Failure
Electrical Stimulation in Patients With Prolonged Mechanical Ventilation
Muscle atrophy and diaphragm dysfunction are common complication in patients with prolong mechanical ventilator (PMV) and is associated with increased rate of weaning failure and days of hospitalization.
- Trial name
- NCT02227810
- Testing
- electrical stimulation (high frequency), electrical stimulation (low frequency)
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Obstructive Pulmonary Diseases
Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal
Chronic Obstructive Pulmonary Disease [COPD] is a major cause of chronic morbidity and mortality worldwide. COPD is characterized by persistent progressive airflow limitation that adversely affects the ventilation/perfusion (V/Q)…
- Trial name
- COPD (NCT03461328)
- Testing
- Magnesium Sulphate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Anesthesia, Obesity, Morbid
Effect of Two Different Doses of Dexmedetomidine Infusion in Morbidly Obese Patients
Compare the effects of two different doses of dexmedetomidine infusion on oxygenation as a primary outcome and on lung mechanics, quality of recovery and perioperative analgesia as secondary outcomes in morbidly obese patients…
- Conditions
- Anesthesia, Obesity, Morbid, Dexmedetomidine
- Trial name
- NCT06018948
- Testing
- Dexmedetomidine 0.6, Dexmedetomidine 0.3, Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
ARDS (Acute Respiratory Distress Syndrome)
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS.
- Trial name
- NCT06790875
- Testing
- Airway Pressure Release Ventilation (APRV)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Silicosis
Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis
Silicosis is a chronic and incurable occupational disease that can progress independent of the end of exposure. Recent works suggest that the Forced Oscillation Technique (FOT) may help to improve our understanding of the changes…
- Trial name
- NCT01725971
- Where
- Brazil
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Different Modes of Respiratory MuscleTraining on Respiratory Mechanics and NRD in Patient With Stable COPD.
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by persistent airflow limitation. The patients are suffering dyspnea year by year, resulting in the decreased exercise tolerance and…
- Trial name
- NCT03500042
- Testing
- inspiratory pressure threshold device
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease
Effect of Pursed Lips Breathing on Chest Wall, Mobility Diaphragmatic and Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease
This study aimed to evaluate the acute effect of PLB technique on diaphragmatic mobility, the kinematics of the thoracoabdominal complex analysis of lung volumes and exercise tolerance in patients with Chronic Obstructive…
- Trial name
- NCT02424331
- Testing
- Pursed Lips Breathing, Quiet Breathing
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Prone Position, Acute Respiratory Distress Syndrome
Prone Position With Different Types of Cushions in Patients With ARDS
The prone maneuver is a well-established therapy in ARDS. Traditionally, the maneuver is perform with thoraco-abdominal cushions.
- Trial name
- PronEIT (NCT06184490)
- Testing
- Prone position with thoraco-abdominal cushion
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury
Evaluation of Respiratory Mechanics in Supine and PARK-bench Positions (SPARK)
The primary objective of this prospective observational physiological study is to evaluate the variation in regional distribution of intrapulmonary volume in the dependent and non-dependent lung regions in patients undergoing…
- Trial name
- SPARK (NCT06448988)
- Testing
- Park Bench position
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preterm Birth, Respiratory Distress Syndrome
Sustained Lung Inflation and Pulmonary Mechanics in Preterm Infant
Lung protection should start in the delivery room where, from the first breaths, the preterm infant can be helped to clear the lung fluid and to recruit alveolar spaces and establish the functional residual capacity (FRC).
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Lung Diseases
- Trial name
- NCT02493920
- Testing
- Sustained lung inflation, mask using a T-piece system (Fabian,Acutronic Medical Systems AG, Switzerland).
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypoxia
The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients
The area of aesthesia-induced atelectasis is much larger in the obese compared with the non-obese, but there may also be more airway closure and impaired matching of ventilation and lung blood flow.
- Trial name
- NCT02961920
- Testing
- IE ratio 1:1, IE ratio 1:2
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Gachon University Gil Medical Center
Pulmonary Hypertension
Effects of Bosentan on Respiratory Mechanics
Bosentan has been largely used in the treatment of pulmonary hypertension (PH). It can improve exercise capacity, lower Borg dyspnoea score nad these effects are usually associated with the concomitant improvement in…
- Trial name
- NCT00679068
- Testing
- Bosentan
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Respiratory Failure, Ventilator-Induced Lung Injury
New Automated System for Continuous Real-time Monitoring of Transpulmonary Pressure
Patients admitted to Intensive Care Unit often are affected by acute respiratory failure at admission or during hospital stay, with a mortality of 30%.
- Trial name
- NCT03945409
- Testing
- OPTIVENT
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Acute Respiratory Distress Syndrome (ARDS)
Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability
This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.
- Trial name
- NCT07504731
- Testing
- Specific lung recruitment maneuvers and decremental PEEP steps
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Trendelenburg, Neumoperitoneum
Different Tidal Volume on Oxygenation, Respiratory Mechanics, and Pulmonary Complications in Older Patients Undergoing Trendelenburg Pneumoperitoneum Surgery
The investigators want to assess the effect of intraoperative low tidal volume vs intermediate tidal volume on respiratory mechanics, oxygenation and pulmonary complications in older patients undergoing Trendelenburg…
- Conditions
- Trendelenburg, Neumoperitoneum, Oxygenation, Respiratory
- Trial name
- NCT06044402
- Testing
- group L (Vt 6 ml/kg), group I (Vt 8 ml/kg)
- Volunteers
- 130 people
- Sponsor
- dong zhang
Pectus Excavatum
Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum
The aim of the current study was to compare the effects of sevoflurane and desflurane on respiratory mechanics in patients undergoing repair of pectus excavatum.
- Trial name
- NCT01486953
- Testing
- Desflurane, Sevoflurane
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- The Catholic University of Korea