Clinical trials: Lung Function
PAH, Pulmonary Hypertension
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients
Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health…
- Conditions
- PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension
- Trial name
- NCT03626688
- Testing
- Ralinepag
- Where
- 209 sites in United States, Argentina and 31 more
- Volunteers
- 687 people
- Sponsor
- United Therapeutics
Pulmonary Function, Incentive Spirometry
Digital Incentive Spirometry Adherence
This single-arm proof-of-concept research study aims to assess the effect of a digital incentive spirometer (IS) device and a companion mobile-based app on incentive spirometry adherence in patients post-surgery.
- Conditions
- Pulmonary Function, Incentive Spirometry, Patient Adherence, Lung Resection
- Trial name
- NCT06629454
- Testing
- Adherence to digital incentive spirometer in the postop period after major chest surgery.
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Pennsylvania
Premature Birth, Bronchopulmonary Dysplasia
Assessment of Lung Structure and Function of Infants Born Prematurely
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
- Conditions
- Premature Birth, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00422305
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Indiana University
COPD
Effects of Manual Diaphragmatic Technique Versus Lateral Coastal Breathing Exercises Among COPD Patients.
Chronic obstructive pulmonary disease is a common, preventable as well treatable disorder, which is also one of the main reasons of high mortality and morbidity characterized by irreversible airflow limitation and has respiratory…
- Trial name
- NCT06844994
- Testing
- Manual Diaphragmatic Technique, Lateral Coastal Breathing
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema
Cardiac Function in Swimming-Induced Pulmonary Edema (SIPE)
Acute or chronic cardiac dysfunction could be a contributing factor to swimming-induced pulmonary edema (SIPE). Knowledge on cardiac function in SIPE is limited and recommendations for cardiac evaluation of patients with SIPE are…
- Conditions
- Swimming Induced Pulmonary Edema (SIPE), Pulmonary Edema, Lung Diseases, Heart Function Tests
- Trial name
- NCT05391737
- Testing
- Echocardiography, Electrocardiogram (ECG), Cardiac biomarkers
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Lung Cancer, Non Small Cell Lung Cancer
Low Volume High Intensity Interval Training in Operated Lung Cancer Patients
Patients included in the study will be randomly divided into 2 groups using appropriate randomization programs. All patients will be given exercise training individually for 24 sessions using a bicycle ergometer under the…
- Trial name
- NCT05837429
- Testing
- Low Volume High Intensity Exercise Training, Aerobic Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Telerehabilitation
The Influence of Telerehabilitation Focused on Respiratory Muscle Training
Pulmonary rehabilitation, which includes respiratory muscle training, is effective in improving the functional status of patients with various types of the respiratory system diseases, including bronchial asthma, interstitial…
- Trial name
- NCT05533151
- Testing
- Respiratory muscle training
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Palacky University
Adolescent Idiopathic Scoliosis, Diaphragmatic Manual Techniques
Three-Dimensional Scoliosis Exercises and Diaphragmatic Manual Techniques in Adolescents With Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine that emerges during growth and is characterized by lateral curvature, vertebral rotation, and trunk asymmetry.
- Conditions
- Adolescent Idiopathic Scoliosis, Diaphragmatic Manual Techniques, Schroth Exercises
- Trial name
- NCT07683533
- Testing
- Diaphragmatic manual techniques, Schroth exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Akdeniz University
Cystic Fibrosis
Modeling of Chest Physiotherapy Using Impedance Measurements (PHYSIOMOD)
"The usefulness of respiratory physiotherapy and its execution modalities remains highly debated even though reviews of the literature show that respiratory physiotherapy is able to improve the drainage of bronchial secretions…
- Trial name
- PHYSIOMOD (NCT04094441)
- Testing
- chest physiotherapy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise
This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.
- Trial name
- NCT04618302
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Thomas Radtke
Covid19, Hiv
Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa
Background: Coronavirus disease 2019 (COVID-19) has affected almost every country in the world, especially in terms of health system capacity and economic burden.
- Conditions
- Covid19, Hiv, ART
- Trial name
- ENDOCOVID (NCT04709302)
- Testing
- COVID-19, HIV, ART
- Where
- 3 sites in Nigeria, South Africa
- Volunteers
- 342 people
- Sponsor
- Medical University of Graz
Pulmonary Resection, Right Ventricular Function
Effects of Pulmonary Resection on Right Ventricular Function
Lung resection is associated with high postoperative morbidity and mortality and leads to a significant long-term decrease in functional capacity, particularly due to cardiorespiratory complications.
- Conditions
- Pulmonary Resection, Right Ventricular Function, Echocardiography, Cardiothoracic Anesthesia
- Trial name
- NCT07042893
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Çağrı Özdemir
Solid Tumor Malignancies, Colorectal Carcinoma
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
The goal of this clinical trial is to learn if an investigational drug CP-383 works to treat advanced cancer. It will also learn about the safety of CP-383.
- Conditions
- Solid Tumor Malignancies, Colorectal Carcinoma, Small Cell Lung Cancer ( SCLC ), Head and Neck (HNSCC)
- Trial name
- NCT07030257
- Testing
- CP-383
- Where
- 13 sites in United States
- Volunteers
- 150 people
- Sponsor
- Tasca Therapeutics
Pulmonary Function, Nutrition, Healthy
Effects of Beetroot Juice Intake on Performance and Physiological Parameters
This study was a randomized, double-blind, crossover design for 3 weeks. In the first week, a researcher explained all the experimental procedures to the participants.
- Trial name
- NCT06073275
- Testing
- Beetroot juice ingestion
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona
Lung Cancer
Vibration Response Imaging (VRI) in Patients Who Are Potential Candidates for Surgical Resection
The primary purpose of the study is to investigate the use of VRI to guide the selection of patients for lung surgery. Perfusion scintigraphy is the current method to assess the fractional contribution of lung function of the…
- Trial name
- NCT00966511
- Testing
- Lung resection surgery
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- Deep Breeze
Chronic Obstructive Pulmonary Disease
The Effect of Maximal Strength Training on Lung Function in Patients With COPD
The purpose of this study is to investigate the effect on maximal strength training on muscle function, lung function and quality of life for patients diagnosed with COPD grade II-III (Gold scale).
- Trial name
- NCT05586399
- Testing
- Maximal strength training in COPD
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Molde University College
Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overweight and Obesity
- Trial name
- FOCuSEd (NCT06390345)
- Testing
- FOCuSEd Integrated Intervention, Enhanced Usual Care
- Where
- 5 sites in United States
- Volunteers
- 400 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
COVID-19 Infection
Long Covid (Individuals with Ongoing COVID-19 Symptoms) Ongoing Effects
Persistent Covid-19 symptoms, known as long Covid, can impact healthcare provision. This study aimed to assess how symptoms persisting six months after Covid-19 affect quality of life and functional capacity.
- Trial name
- COVID-19 (NCT06528145)
- Testing
- Evalation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ziya Yildiz
Respiratory Function Loss, Respiratory Complication
A Study to Investigate the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle
The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.
- Trial name
- NCT05856136
- Testing
- Fentanyl Injection
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Mayo Clinic
Chronic Lung Allograft Dysfunction Lung MRI (CLAD)
Chronic Lung Allograft Dysfunction MRI Study
This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology.
- Trial name
- NCT06406777
- Testing
- Spirometry, Contrast Lung Computed Tomography (CT) Scan, Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sean Fain