Clinical trials: Lumbar Puncture
Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-Small Cell Lung Cancer
This phase I trial assesses the use of lumbar punctures to detect whether there is circulating tumor deoxyribonucleic acid (ctDNA) in the fluid that surrounds the brain and spinal cord (cerebrospinal fluid) in patients with stage…
- Conditions
- Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06816979
- Testing
- Biospecimen Collection, Lumbar Puncture, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Headache, Meningitis
Does Static Ultrasound-Preview Reduce the Incidence of Difficult Lumbar Puncture?
Does the use of ultrasound facilitate a lumbar puncture by reducing the number of difficult and traumatic lumbar punctures?
- Conditions
- Headache, Meningitis, Subarachnoid Hemorrhage
- Trial name
- NCT00317382
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Pain
"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
The study's hypothesis is LMX4 cream, a topical anesthetic cream, will reduce the pain of infants undergoing Lumbar Puncture (spinal tap).
- Trial name
- NCT00533468
- Testing
- Lidocaine Cream 4%
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- State University of New York at Buffalo
Pregnancy, Caesarean Section
Pendant Position and Traditional Sitting Position for Successful Spinal Puncture in Spinal Anaesthesia
The aim of this study was to compare the successful spinal puncture among patients with pendant position in comparison with those who used traditional sitting position for caesarean section.
- Trial name
- NCT02753660
- Testing
- Traditional sitting position, Pendant position
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Hunter Syndrome
Collection and Study of Cerebrospinal Fluid in Patients With Hunter Syndrome
The purpose of the study is to collect data on CSF biomarkers in patients with Hunter Syndrome that would serve as reference data for comparison with cognitively impaired patients with Hunter syndrome, patients with other…
- Trial name
- NCT01449240
- Testing
- No treatment
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 10 people
- Sponsor
- Shire
HIV Infection
The Efavirenz (EFV) Central Nervous System Exposure Sub-study of Encore1
Persistent HIV infection in the central nervous system (CNS) compartment may put subjects at risk of developing HIV-related brain disease.
- Trial name
- ENCORE1-CNS (NCT01451333)
- Testing
- Efavirenz
- Where
- 5 sites in Germany, Thailand and 1 more
- Volunteers
- 32 people
- Sponsor
- Kirby Institute
Infant/ Neonate Lumbar Puncture
Bedside Ultrasound Assisted Pediatric Lumbar Puncture
This is a prospective, randomized study evaluating the efficacy of bedside ultrasound assisted lumbar puncture in pediatric patients
- Trial name
- NCT02193763
- Testing
- Ultrasound assisted lumbar puncture
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Nervous System Diseases
Cerebrospinal Fluid Collection and Repository Storage
Background: Cerebrospinal fluid (CSF) is the liquid around the brain and spinal cord. Many diseases can only be diagnosed by examining the CSF. A lumbar puncture is used to collect and test CSF.
- Trial name
- NCT01862107
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spontaneous Intracranial Hypotension, Intracranial Hypotension
Pathophysiology and Treatment of Cerebrospinal Hypotension Exploration Study
The goal of this observational study is to learn about the effects of a low-pressure environment on the brain in patients with intracranial hypotension and to potentially improve diagnostics and treatment of this condition.
- Conditions
- Spontaneous Intracranial Hypotension, Intracranial Hypotension, Post-Lumbar Puncture Headache
- Trial name
- PATCHES (NCT06805591)
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Syphilis
Lumbar Puncture and Syphilis Outcome
Treponema pallidum, the bacterium that causes syphilis, invades the central nervous system in about 40% of patients with syphilis. This happens early after infection.
- Trial name
- NCT02031146
- Testing
- Lumbar puncture
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- University of Washington
Lower Limb Fracture
Combined Lumbar and Sacral Branches Block Through the Ilio-Psoas Muscle Spaces for Analgesia of Lower Limb Surgeries
lumbosacral plexus block (LSPB) has been widely applied in orthopedics departments due to its advantages, including reduction in the application of opiates, decreasing the occurrence of acute pain, promoting early activation, and…
- Trial name
- NCT06019754
- Testing
- one point combined Lumbar and sacral plexus block
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Zagazig University
Traumatic Lumbar Puncture
Variability of Infant LP Insertion Site Based On Procedural Experience
The reported rate of unsuccessful traditional LP in children (defined as the inability to obtain cerebrospinal fluid or obtaining a traumatic puncture) is as high as 50%.
- Trial name
- NCT02949869
- Testing
- Spinal Sonography
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Indication for Lumbar Puncture
The Effectiveness of a Pediatric Lumbar Puncture Restraint Device
This is a pilot study to evaluate a restraint device for lumbar punctures. Designed to help improve the restraint techniques for lumbar puncture, the restraint device will be compared to the current standard of manual physical…
- Trial name
- SNOWBOARD (NCT00980070)
- Testing
- Pediatric Restraint for Lumbar Puncture, Lumbar Puncture Device, Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Leukemia
Virtual Reality as a Distraction Technique for Performing Lumbar Punctures in Children and Young Adu
The goal of this feasibility study is to determine if Virtual Reality (VR) can be adequately used as an alternative to General Anesthesia (GA) for Lumbar Punctures (LP).
- Trial name
- NCT04092803
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Epilepsy
Herpes Virus-6 and Epilepsy
This study will explore whether the human herpes virus-6 is associated with epileptic seizures. The virus may be involved in brain scarring, called mesial temporal sclerosis, which is seen in some epilepsy patients.
- Trial name
- NCT00085683
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pain
Video/Audio Distraction Analgesia for Simulated Oncology Procedure Pain
The purpose of this study is to compare the analgesic efficacy of three different types of video/audio distraction in normal volunteers subjected to carefully controlled and non-injurious thermal pain delivered to the skin of the…
- Trial name
- NCT00701571
- Testing
- Virtual Reality distraction
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Washington
Headache
Juvenile Postlumbar Puncture Headache After Puncture With Needles With Quincke Tip or With Sprotte Tip
The purpose of this study is to compare postlumbar puncture complaints as headache or backache after lumbar puncture with needles with Quincke design or with Sprotte design in children and adolescents.
- Trial name
- NCT00450060
- Testing
- lumbar puncture with Quincke-design needles, lumbar puncture with Sprotte-design needles
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University
Informed Consent, Health Literacy, Risk, Spinal Puncture, Neurosurgery
Communicating Risks: Consent for Lumbar Puncture
The goal of this randomized control trial is to compare the effect of visual aids on the recall of probabilistic risks in healthy participants.
- Trial name
- NCT05717465
- Testing
- Anatomy diagrams, Standard informed consent
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Lumbar Puncture
SHAPE for ICP Assessment
The Subharmonic Aided Pressure Estimation (SHAPE) technique is a noninvasive ultrasound-based imaging technique that can estimate ambient pressure using subharmonic emissions from ultrasound contrast agents.
- Trial name
- NCT06571786
- Testing
- Perflutren lipid microsphere
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Pain Management
Epidural Injection of Corticosteroids Under USG (EICUS)
Qualitative and quantitatively evaluate the pain control and incidence of adverse effects in patients undergoing corticosteroid infiltration and local anesthetic through sacral epidural puncture with ultrasound assistance or…
- Trial name
- EICUS (NCT02860078)
- Testing
- Ultrasound, Radioscopy
- Where
- Brazil
- Sponsor
- University of Sao Paulo General Hospital