Clinical trials: Lower Limb Amputation Knee
Lower Extremity Amputation
Adherence and Perspiration While Wearing Lower Limb Prostheses
Individuals with lower limb amputation often complain about uncomfortable residual limb skin temperatures and the accumulation of sweat inside their prostheses.
- Trial name
- NCT03900845
- Testing
- Dynamic Air Exchange - Rising Edge Design (DAE-RED), Perforated elastomeric liner, As-prescribed prosthesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Fractures, Bone, Stroke
Tele-Rehabilitation Pilot Evaluation Study
A proof of concept randomized controlled trial (RCT) only evaluated the National University of Singapore's (NUS) T-Rehab tele-rehabilitation (TR) system at a home setting where rehabilitation was provided on an individual level.
- Conditions
- Fractures, Bone, Stroke, Lower Limb Joint Replacement (Hip or Knee), Lower Limb Amputation
- Trial name
- NCT03409354
- Testing
- Tele-rehabilitation, Usual care
- Where
- Singapore
- Volunteers
- 14 people
- Sponsor
- National University of Singapore
Lower Limb Amputation Above Knee (Injury)
Analyzing Stump-socket Interface Pressure to Improve Gait in Above-knee Amputee
This study aims at evaluating the relation between quality of the interface between the stump and the prosthesis, and the quality of gait in above-knee amputees.
- Trial name
- NCT01848964
- Testing
- Clinical and instrumented measurements
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Lower Limb Amputation Above Knee (Injury)
Above-knee Socket Evaluation : Sub-ischial vs Ischial Containment
Socket is key to provide comfort and function to lower limb amputees. A new socket, the sub-ischial socket, will be compared to "traditional" ischial containment sockets, based on comfort self-evaluation, and locomotor capacities.
- Trial name
- P20-EMBSUBI (NCT04791163)
- Testing
- Socket evaluation
- Where
- 9 sites in France
- Volunteers
- 25 people
- Sponsor
- Proteor Group
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
Pain in Trans Femoral and Trans Tibial Amputees
Phantom limb is difficult to manage and has a significant impact on the patient's quality of life. At present, the scientific evidence shows that the infusion of local anesthetics with epidural and perineural catheters in the…
- Trial name
- AMPUPHANTOM (NCT03789435)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Istituto Ortopedico Rizzoli
Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury)
Enhancing Abilities in Amputees and Patients With Peripheral Neuropathy Through Restoration of Sensory Feedback
Many amputees suffer from Phantom Limb Pain (PLP), a condition where painful perceptions arise from the missing limb. Leg amputees wear prostheses that do not provide any sensory feedback, apart from the stump-socket interaction.
- Conditions
- Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Diabetic Peripheral Neuropathy
- Trial name
- NCT04217005
- Testing
- Sensory Feedback
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- ETH Zurich
Parkinson's Disease and Parkinsonism, Dementia
Context- and Terrain-aware Gait Analysis
The average lifespan of individuals in many developed countries is increasing. This factor paired with the increase in global population has the potential to put a strain on healthcare systems with regards to age-related…
- Conditions
- Parkinson's Disease and Parkinsonism, Dementia, Acquired Brain Injury, Multiple Sclerosis
- Trial name
- CTAGA (NCT07491588)
- Testing
- All-terrain Gait Analysis System
- Sponsor
- University of Leeds
Lower Limb Amputation Below Knee (Injury)
Comprehensive Evaluation of the Passive Talaris Demonstrator
The passive Talaris Demonstrator (TD) is developed in continuation of previous prototypes. The main goal of the experiment is to evaluate the effectiveness of TD during daily activities.
- Trial name
- NCT05127993
- Testing
- Passive Talaris Demonstrator
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Amputation
Effect of Socket Wall Height With Vacuum Suspension for Above Knee Amputees
Individuals with transfemoral (TF) amputation (above the knee amputation) may benefit from a socket that uses vacuum assisted suspension (VAS) to hold the socket onto the amputated limb.
- Trial name
- NCT01559909
- Testing
- Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Stony Brook University
Diabetic Foot, Ischemic Leg
Skew Flap vs Long Posterior Flap for Below Knee Amputation Early and Short- Term Outcomes
Below knee amputations (BKAs) are frequently performed among vascular patients with end stage chronic limb threatening ischemia and / or complications of diabetes and diabetic foot infections and gangrene, It may also be…
- Trial name
- NCT06499506
- Testing
- Below knee amputation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Amputation, Lower Limb
Virtual Reality in the Rehabilitation in Patients With Lower Limb Amputation.
The goal of this clinical trial is to test the impact of virtual reality on rehabilitation for the patients after a major amputation.
- Conditions
- Amputation, Lower Limb, Rehabilitation, Activities of Daily Living
- Trial name
- NCT05773560
- Testing
- virtual reality rehabilitation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Erlangen
Lower Limb Amputation Above Knee (Injury)
New Microprocessor-Controlled Prosthetic Knee Evaluation
The target of this clinical investigation is to compare the achievement of personal functional goals using a new MPK and current MPK.
- Trial name
- NCT06017024
- Testing
- microprocessor-controlled knee (MPK) assessment
- Where
- 5 sites in France
- Volunteers
- 18 people
- Sponsor
- Proteor Group
Intrathecal, Dexmedetomidine
Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity
The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.
- Conditions
- Intrathecal, Dexmedetomidine, Fentanyl, Bupivacaine
- Trial name
- NCT07276867
- Testing
- Fentanyl + Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- National Cancer Institute, Egypt
Lower Limb Amputation Below Knee (Injury)
NIH Release/Relock Socket
The goal of the research is to create and evaluate a new technology for management of daily residual limb fluid volume fluctuation.
- Trial name
- NCT04305782
- Testing
- Release/Relock Socket - In Lab, Release/Relock Socket - Out of Lab, Release/Relock Socket & Control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Amputees, Amputation
Extremity Thermographic Values in Individuals With Transtibial Amputation
The goal of this observational study is to compare thermographic values in the knee region of the healthy extremity and the amputated extremity and learn about the relationship between thermographic value and pain in the knee…
- Conditions
- Amputees, Amputation, Amputation Stump, Amputation of Knee
- Trial name
- NCT06258343
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Baskent University
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
Study on a Prosthetic Foot With Adjustable Heel Height
Most prosthetic feet have a fixed heel height, which requires users to always wear shoes with the same heel height. A fixed heel height is a significant constraint, whereas the ability to choose one's clothing freely is an…
- Trial name
- ADJUST (NCT07214493)
- Testing
- Taleo Adjust, The usual participant's foot
- Where
- 5 sites in France
- Volunteers
- 30 people
- Sponsor
- Otto Bock France SNC
Diabetic Foot Disease, Diabetic Foot Infection
Intraosseous Versus Intravenous Vancomycin in Below-Knee Amputation for Ischemic Diabetic Foot
This randomized clinical trial compared two routes of vancomycin administration in patients undergoing below-knee amputation for ischemic diabetic foot infection.
- Conditions
- Diabetic Foot Disease, Diabetic Foot Infection, Diabetic Amputation Foot Wound
- Trial name
- NCT07338773
- Testing
- Intraosseous Vancomycin, Intravenous Vancomycin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Amputation of Lower Limb Below Knee, Amputation, Traumatic
REsistance and LOADing Exercise for Bone Health
Lower limb amputation, often resulting from military conflict and road traffic accidents, is associated with reduced hip bone mineral density (BMD) and increased risk of hip fractures.
- Conditions
- Amputation of Lower Limb Below Knee, Amputation, Traumatic, Amputation, Limb Loss
- Trial name
- RELOAD (NCT07817381)
- Testing
- Resistance and high-impact exercise training
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Defence Medical Rehabilitation Centre, UK
Diabetes Mellitus, Type 2
Sodium-glucose Co-transporter 2 (SGLT2) Inhibitor Risk of Below-Knee Lower Extremity Amputation: A Retrospective Cohort Study Using a Large Claims Database in the United States
The purpose of the study is to estimate the incidence of below-knee lower extremity amputation in type 2 diabetes mellitus (T2DM) participants newly exposed to sodium-glucose co-transporter 2 inhibitors (SGLT2i)/ non-SGLT2i…
- Trial name
- NCT02857764
- Volunteers
- 127,690 people
- Sponsor
- Janssen Research & Development, LLC
Peripheral Arterial Disease, Peripheral Vascular Disease
The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD
Lower limb amputation is common in the United States, with approximately 150,000 amputations annually. Most individuals walking with a prosthesis demonstrate asymmetrical loading-i.e., they favor the amputated side by placing…
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee
- Trial name
- NCT04937179
- Testing
- Ischemic Conditioning High - Active Comparator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Illinois Chicago