Clinical trials: Lower Extremity Wound
Infections, Infected Wound
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics.
- Conditions
- Infections, Infected Wound, Nonunion of Fracture, Injury Leg
- Trial name
- POvIV2 (NCT05699174)
- Testing
- Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
- Where
- 13 sites in United States
- Volunteers
- 250 people
- Sponsor
- Major Extremity Trauma Research Consortium
Amputation, Wound; Foot
Comparing Wound Complication Following TMA With Aid of Electrospun Fiber Matrix
Transmetatarsal amputation (TMA) patient populations commonly have poor healing outcomes and a large number of complications. There has been little study on the benefits of augmenting a TMA with a synthetic graft substitute.
- Conditions
- Amputation, Wound; Foot, Wound Complication
- Trial name
- NCT06063694
- Testing
- Synthetic electrospun fiber matrix
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Diabetic Foot Ulcer
Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers
This study is a double-blind, one center, two-arm study with a two (2) week Run-In, evaluating the efficacy of a once-daily administration of NanoDOX™ Hydrogel topically applied to diabetic ulcers in concert with professionally…
- Trial name
- NCT00764361
- Testing
- doxycycline
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NanoSHIFT LLC
Somatic Dysfunction of Sacral Region, Somatic Dysfunction of Both Sacroiliac Joints
An Osteopathic Assessment of Lower Extremity Somatic Dysfunction in Runners
Runners often experience acute/chronic pain due to pre-existing structural somatic dysfunction and/or acquired various overuse injuries of the lower extremity, specifically affecting the ligaments, tendons, muscles and bones.
- Conditions
- Somatic Dysfunction of Sacral Region, Somatic Dysfunction of Both Sacroiliac Joints, Somatic Dysfunction of Bilateral Lower Extremities
- Trial name
- NCT05132894
- Testing
- Osteopathic Assessment
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- The Touro College and University System
Diabetic Foot Ulcer (DFU)
Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers
The goal of this clinical trial is to learn if using FoundationDRS Solo improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT07290673
- Testing
- FoundationDRS Solo, Standard of Care
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Samaritan Biologics
Surgical Wound Infection
The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal
The goal of this clinical trial is to learn if reducing bacterial load on the skin and nostrils with topical antibacterial soap and ointment, respectively, reduces rate of infection in surgical sites on lower leg wounds left open…
- Trial name
- NCT07142408
- Testing
- Chlorhexidine gluconate (4%), Mupirocin 2% Ointment
- Where
- United States
- Volunteers
- 848 people
- Sponsor
- The Cooper Health System
Postural Stability, Dynamic Knee Valgus
The Effect Subtalar Joint Pronation on Postural Stability and Lower Extremity Alignment
The lower extremity consists of sequent columns. The deviation of one segment from its normal alignment in the lower extremity also affects the alignment of the other segments.
- Conditions
- Postural Stability, Dynamic Knee Valgus, Injury Prevention
- Trial name
- NCT05606835
- Testing
- Postural stability assessment, Frontal plan prjection angle, Foot and Ankle Ability Measure
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Diabetic Foot
Accelerated Wound Healing in Diabetic Ulcers by Sitagliptin
The purpose of the study is to test the effect of Sitagliptin on the healing of stable, nonhealing diabetic foot ulcers. This is a randomized placebo-controlled Trial.
- Trial name
- SitaDFU (NCT02675335)
- Testing
- Sitagliptin
- Sponsor
- Wolfgang-Michael Franz
Postoperative Pain, Lower Limb Injury
Block Duration After Spinal Block and iv Dexamethasone.
It has been largely demonstrated that iv dexamethasone prolongs the duration of analgesia after peripheral nerve block. However, data are missing regarding the duration of analgesia after spinal block.
- Trial name
- NCT03527576
- Testing
- Dexamethasone, NaCl 0.0308 MEQ/ML Injectable Solution
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Eric Albrecht
Athletic Injuries
Prevention of Lower Limb and Groin Injuries: the Sport Without Injury ProgrammE (SWIPE) Football Trial
This is a three-armed intervention study that evaluates the injury preventive effects of three different training interventions in youth and adult football players.
- Trial name
- SWIPEsoccer (NCT04272047)
- Testing
- Knee Control+ program, Adductor strengthening program, Knee Control program
- Where
- Sweden
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Diabetic Foot Ulcer, Type 1 Diabetes Mellitus
Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
The goal of this investigational study is to evaluate the safety and clinical performance of Tropocells Autologous Platelet-rich Fibrin (PRF) for wound care for both males and females, ages 18-80 years old, with Grade 1 and 2…
- Conditions
- Diabetic Foot Ulcer, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Neuroischemic Foot Ulcer
- Trial name
- NCT06810726
- Testing
- Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Estar Medical dba Medical Technologies, LTD
Peripheral Vascular Disease, Claudication
Oral Nutritional Supplement in Reducing Surgical Site Infections
The study aims to evaluate the efficacy of an arginine enriched oral nutritional supplement in the prevention of wound complications in the the wounds of patients post lower limb revascularization.
- Trial name
- NCT02475525
- Testing
- Arginine enriched oral nutritional supplement
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- University of Limerick
Diabetic Foot Ulcer
Effects of High Voltage Pulsed Current (HVPC) and Low Level Laser Therapy (LLLT) on Wound Healing in Diabetic Ulcers
The purpose of this study was to compare the effects of high voltage pulsed current and low level laser therapy on the healing process of diabetic foot ulcers.
- Trial name
- NCT00719251
- Testing
- High voltage pulsed current, Low level laser, Standard nursing care
- Where
- Colombia
- Volunteers
- 28 people
- Sponsor
- Universidad Industrial de Santander
Burns
Effect of Core Stability and Sensorimotor Training Exercises on Postural Stability Post Lower Limb Burn
The purpose of the study is to determine the effect of core stability and sensorimotor training exercises on postural stability post lower limb burn.
- Trial name
- NCT06718829
- Testing
- Core Stability Exercises, Sensorimotor Training Exercises, Traditional physical therapy program
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Diabetic Foot Ulcers
Investigation of Subatmospheric Pressure Dressing on Pressure Ulcer Healing
Many spinal cord injury (SCI) and otherwise debilitated patients develop pressure ulcers over the course of their injury or disease.
- Trial name
- NCT00011531
- Testing
- Prevention of Pressure Ulcers
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Foot Ulcers (DFU), Venous Stasis Ulcers (VSU)
OASIS Wound Matrix (Oasis) Mechanism of Action
OASIS Wound Matrix (Oasis) will be applied to wounds, with sequential biopsy of healing wounds to explore the mechanism of action.
- Trial name
- NCT00570141
- Testing
- OASIS Wound Matrix
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- Healthpoint
Gait Disorder, Sensorimotor
The Effects of Gait Performance and Brain Activity After Robot-assisted Gait Training (RAGT) On Patients With Lower Extremity Thermal Injury
Gait enables individuals to move forward and is considered a natural skill. Gait disturbances are very common in patients with burn injury. Major causes of gait disturbances are pain and joint contractures.
- Trial name
- NCT05988905
- Testing
- robot assited gati training, conventional traiing
- Volunteers
- 40 people
- Sponsor
- Hangang Sacred Heart Hospital
Skin Tumor
Negative-pressure Wound Therapy on Full-thickness Skin Grafts of the Lower Leg
This randomized controlled non-sponsored trial on 60 patients evaluates if a portable negative-pressure device improves graft-take and decrease the risk of surgical complications for skin-cancer surgeries below the knee.
- Trial name
- NCT05451680
- Testing
- Negative pressure device, Conventional care
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Fractures, Bone, Stroke
Tele-Rehabilitation Pilot Evaluation Study
A proof of concept randomized controlled trial (RCT) only evaluated the National University of Singapore's (NUS) T-Rehab tele-rehabilitation (TR) system at a home setting where rehabilitation was provided on an individual level.
- Conditions
- Fractures, Bone, Stroke, Lower Limb Joint Replacement (Hip or Knee), Lower Limb Amputation
- Trial name
- NCT03409354
- Testing
- Tele-rehabilitation, Usual care
- Where
- Singapore
- Volunteers
- 14 people
- Sponsor
- National University of Singapore