Clinical trials: Lower Extremity
Restless Leg Syndrome
Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrome
The study will compare the safety, effectiveness and tolerability of gabapentin (Neurontin) versus gabapentin enacarbil (Horizant) as treatment restless leg syndrome.
- Trial name
- NCT02117076
- Testing
- Gabapentin immediate release, Gabapentin enacarbil extended release
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Theresa Zesiewicz, MD
ACL, Anterior Cruciate Ligament Injuries
Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery
The purpose of this randomized controlled trial is to assess a new analgesia regimen that includes the addition of genicular never blocks to our current standard regimen of peripheral nerve blocks, which includes an adductor…
- Trial name
- NCT05720949
- Testing
- Genicular Nerve Block with bupivacaine and preservative free dexamethasone
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Hospital for Special Surgery, New York
Flatfoot
Acute Effects of Foot Orthoses on Muscle Mechanical Properties in Individuals With Pes Planus
This randomized controlled study will examine the acute effects of a medial arch support and a prefabricated insole on lower-limb muscle mechanical properties and pain in young adults with pes planus.
- Trial name
- NCT07755215
- Testing
- Insole, Medial Arch Support
- Volunteers
- 90 people
- Sponsor
- Medipol University
Arteritic Leg Ulcer
Anatomical Study of the Arteries of the Skin on Amputation Legs
PRIMARY OBJECTIVE Qualitatively describe the distribution of cutaneous arteries in patients with long-term occlusive arterial disease.
- Trial name
- APIA (NCT03618615)
- Testing
- artericitc surgery
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Total Hip Arthroplasty, Degenerative Joint Disease of Hip
G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study
The main objectives of this study are to confirm the long-term safety, performance, and clinical benefits of the G7 Acetabular Shells when used with the Vivacit-E and Longevity HXLPE liners and instrumentation in primary and…
- Conditions
- Total Hip Arthroplasty, Degenerative Joint Disease of Hip, Avascular Necrosis of Hip, Rheumatoid Arthritis of Hip
- Trial name
- NCT04754087
- Testing
- Vivacit-E and Longevity (HXLPE) Liners
- Where
- 11 sites in United States, Denmark and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Lower Limb Injury
Improving Walking After a Lower Limb Injury Using a Custom Motorized Orthosis
The purpose of this research study is to assess the ease, convenience, and efficacy of walking when using a motor powered ankle foot orthosis (AFO) brace, in adults who have had a lower limb injury.
- Trial name
- NCT06923293
- Testing
- Utilization of motorized orthosis
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kessler Foundation
Hypertension, Dementia
BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?
High blood pressure (present in 1 of 5 Canadian adults) increases the risk of heart attack and stroke. Blood pressure lowering pills reduce this risk - but perhaps not optimally.
- Trial name
- NCT04054648
- Testing
- Bedtime administration of the participant's pre-existing antihypertensive medications
- Where
- Canada
- Volunteers
- 776 people
- Sponsor
- University of Alberta
Diabetic Foot Ulcer
Adipose Derived Regenerative Cells In the Treatment of Diabetic Foot Ulcers
A Prospective, Double-blind, Multi-center, Randomized, Parallel-group safety and efficacy study of adipose-derived regenerative cells (ADRCs) in the treatment of patients with diabetic foot ulcers (DFU).
- Trial name
- ASCEND (NCT05095389)
- Testing
- ADRCs, standard care
- Volunteers
- 290 people
- Sponsor
- Paracrine, INC.
Nutrition, Postoperative Pain
Relationship Between Fracture Type and Preoperative Nutritional Status with Postoperative Pain
The geriatric patient group is a population that should be considered differently than other age groups due to physiological characteristics that change with age.
- Conditions
- Nutrition, Postoperative Pain, Hip Fracture, Geriatric
- Trial name
- NCT06784089
- Testing
- Geriatric Nutrition Risk Index, visual analog scale
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Peripheral Arterial Disease, Critical Lower Limb Ischemia
Safety and Feasibility of Surmodics SUNDANCE™ Drug Coated Balloon
To evaluate the safety and performance of the Sundance™ DCB in subjects with occlusive disease of the infrapopliteal arteries.
- Trial name
- SWING (NCT04107298)
- Testing
- SUNDANCE™ Drug Coated Balloon
- Where
- 8 sites in Australia, Austria and 3 more
- Volunteers
- 35 people
- Sponsor
- SurModics, Inc.
Ankle Injuries
Ankle Athletic Taping Fatigue After a Standard Tennis Warm up
Identify, quantify and compare the fatigue caused in two ankle athletic tapes after the completion of a tennis warm-up.
- Trial name
- NCT02187406
- Testing
- Modified ankle athletic taping, Traditional ankle athletic taping
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CEU San Pablo University
Achilles Tendinopathy, Patellar Tendinopathy
Early Implementation of Plyometric Exercises in the Rehabilitation of Individuals Suffering From Lower-Extremity Tendinopathies
This clinical trial aims to compare the effectiveness of an early plyometric exercise approach with traditional heavy, slow resistance training in treating tendinopathies of the Achilles tendon, patellar tendon, and plantar…
- Conditions
- Achilles Tendinopathy, Patellar Tendinopathy, Plantar Fasciopathy
- Trial name
- NCT06774547
- Testing
- Heavy-slow resistance training, Plyometric exercise
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aalborg University
Multi-ligament Knee Injury
Losartan to Improve Outcomes After Multi-ligament Knee Injury
Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events.
- Trial name
- LION (NCT06933706)
- Testing
- losartan 25 mg
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Brigham and Women's Hospital
Osteoporosis, Frailty
Spitex-SpiTal-Autonomie-Reha-Kraft
The primary purpose of this study is to test if the STARK comprehensive autonomy health care package improves lower extremity function over time at 6 weeks, 3, 6 and 12 months after hip or pelvis fracture compared to the standard…
- Conditions
- Osteoporosis, Frailty, Hip Fractures
- Trial name
- STARK (NCT03154684)
- Testing
- STARK intervention, Standard of Care
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University of Zurich
Ankle Stiffness
Effects of Dry Needling the Calf Muscles on Biomechanics and Muscle Function in Individuals With Restricted Dorsiflexion
The goal of this observational study is to learn about the acute effects of dry needling the soleus muscle in individuals with limited ankle mobility
- Trial name
- NCT07474948
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Dayton
Pain, Postoperative, Ankle Fracture Surgery
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Addictive full-agonist opioids, like oxycodone and hydrocodone, are often used to treat pain after surgery. However, these full-agonist opioids can be very addictive.
- Conditions
- Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence
- Trial name
- BAFA (NCT06949826)
- Testing
- Buprenorphine Transdermal System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jenna-Leigh Wilson
Geriatric Hip Fracture
A Comparative Evaluation of Nottingham Hip Fracture Score (NHFS) and Acute Physiology and Chronic Health Evaluation (APACHE) II Score to Predict 30-day Mortality in Geriatric Patients Above 60 Years Undergoing Hip Fracture Surgery.
This study aims to compare the Nottingham Hip Fracture Score (NHFS) and the Acute Physiology and Chronic Health Evaluation II (APACHE II) score in predicting 30-day mortality in geriatric patients over 60 years old undergoing hip…
- Trial name
- NCT06598566
- Testing
- Nottingham Hip Fracture Score (NHFS) score, Acute Physiology and Chronic Health Evaluation (APACHE)-II score
- Where
- India
- Volunteers
- 182 people
- Sponsor
- Tata Main Hospital
Diabetic Foot Ulcer
Diabetes Foot Care Clinical Pathway - Orpyx Medical Technologies
In 2011, the premiers of all Canadian provinces and territories selected diabetes foot care as one of three significant targets for pan-provincial action.
- Trial name
- DFCCP-Orpyx (NCT02994966)
- Testing
- Surrosense, Standard care
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University of Alberta
Ankle Sprain
A Comparison of Early Mobilization Versus Traditional Treatment for Acute Ankle Sprains.
Acute ankle sprain is one of the most common musculoskeletal injuries, accounting for an estimated 2 million injuries per year and 20% of all sports injuries in the United States.
- Trial name
- NCT01134653
- Testing
- Jump Stretch
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Nationwide Children's Hospital
Cartilage, Articular, Tibial Meniscus Injuries
Blood Flow Restriction Training in Patients With Weight Bearing Restrictions After Knee Surgery
After a cartilage or meniscus repair in the knee joint, the patients experience a pronounced and persistent decrease of knee-extension strength in the operated leg, which negatively affect patients' functional performance and…
- Trial name
- NCT03371901
- Testing
- Physical therapy with BFR-LLST
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Health Centre Nørrebro, City of Copenhagen