Clinical trials: Longevity
Liver Failure
RCA for CRRT in Liver Failure and High Risk Bleeding Patients
The purpose of this single center, randomized, control, open-labeled study is to evaluate the effect and safety of RCA versus no anticoagulation for CRRT in patients with liver failure and high risk bleeding.
- Trial name
- NCT03791190
- Testing
- Regional citrate anticoagulation, No-anticoagulation
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Air Force Military Medical University, China
Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial
The European population is aging rapidly which poses a challenge on the individual, the European societies, and health care systems.
- Trial name
- DO-HEALTH (NCT01745263)
- Testing
- Vitamin D3, Omega 3 fatty acids, Strength Home Exercise
- Where
- 7 sites in Austria, France and 3 more
- Volunteers
- 2,157 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Prostate Cancer
Metformin And Longevity
This is a randomized, placebo-controlled, double-blind, window of opportunity study investigating the biological mechanism of metformin in prostate cancer.
- Trial name
- METAL (NCT02511665)
- Testing
- Metformin, PET-MRI Scan
- Where
- United Kingdom
- Volunteers
- 185 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Aging
Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks
This study tests whether certain medicines and a skin treatment can slow down or partly reverse the body's aging process. As people age, the activity of their genes changes in predictable ways.
- Trial name
- NCT07888595
- Testing
- Topical anti-aging peptide serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Frontiers in Bioscience Research Institute and Aging
Metabolic Syndrome
Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome
Background. The prevalence of type 2 diabetes mellitus (T2D) in the world is constantly increasing. Treatment of T2D is complicated by arterial hypertension and obesity (metabolic syndrome - MS).
- Trial name
- NCT06410352
- Testing
- Semaglutide, Empagliflozin, Minigastric bypass, Analimentary detoxication
- Where
- Kazakhstan
- Volunteers
- 220 people
- Sponsor
- University Medical Center, Kazakhstan
Aging, Walking
Cadence and Intensity Across the Adult Lifespan
The purpose of this study is to determine and link cadence (the number of steps taken in a minute) to the intensity of physical activity (e.g. low-, moderate- and vigorous-intensity) in adults (21-85 years old).
- Conditions
- Aging, Walking, Motor Activity, Activities of Daily Living
- Trial name
- CADENCE-Adults (NCT02650258)
- Testing
- treadmill walking
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Total Laryngectomy Patients Who Use Voice Prostheses
Mixed-species Biofilms and Silicone Device Longevity
The purpose of this study is to determine whether the mix of microbial species isolated from biofilm-clogged voice prostheses is specific to each participant, whether the microbes are orally-derived and whether the presence of…
- Trial name
- NCT02507401
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Aberdeen
Cardiovascular Disease
Expression of Longevity Genes in Response to Extended Fasting
The purpose of this study is to evaluate the effect of fasting on physical changes associated with cardiovascular disease.
- Trial name
- FEELGOOD (NCT01059760)
- Testing
- Fasting First, Fed First
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Aging, Longevity
Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life
The LONG-LIFE study is a randomized Phase I, dose-ranging trial designed to evaluate whether psilocybin impacts aging-related biomarkers, cognitive function, and purpose/meaning in life in medically stable older adults.
- Conditions
- Aging, Longevity, Biomarkers of Aging
- Trial name
- LONG-LIFE (NCT07719088)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles Raison
Aging, Cellular Senescence
BIOANCIENT_EX: Effects of a Physical Exercise Program in Centenarians of the BIOANCIENT Cohort: A Randomized Clinical Trial.
This study aims to evaluate the effects of a home intervention of individualized multicomponent physical exercise program (including strength, balance, flexibility, and mobility training) on functional health, physical capacity…
- Conditions
- Aging, Cellular Senescence, Biomarkers / Blood, Exercise
- Trial name
- BIOANCIENT_EX (NCT07723339)
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion Miguel Servet
Longevity, Healthy Aging
Collagen Peptides and Cellular Aging
The goal of this clinical trial is to learn if daily collagen peptide supplementation can stabilize or lengthen telomeres and improve related markers of cellular aging in adults aged 50-70 years with overweight and…
- Conditions
- Longevity, Healthy Aging, Biological Ageing
- Trial name
- NCT07456449
- Testing
- Collagen peptides
- Where
- Austria
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Vienna
End Stage Renal Failure on Dialysis, Hyperplasia
Safety Study of the Vascular Wrap Paclitaxel-Eluting Mesh for Hemodialysis Vascular Access
The purpose of this study is to determine whether the long term use of the experimental Vascular Wrap(TM) Paclitaxel-Eluting Mesh is safe in the treatment of subjects needing hemodialysis access (via an expanded…
- Trial name
- NCT01033357
- Testing
- Graft, Vascular Wrap, Lifespan® ePTFE Vascular Graft Only
- Where
- 30 sites in United States
- Volunteers
- 222 people
- Sponsor
- Angiotech Pharmaceuticals
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Obesity
The Experience of Affective Touch in Obesity
The aim of the present research is to verify if the pleasantness of affective touch is comparable between women with obesity and healthy women, while measuring the level of social anhedonia and the lifespan experience of…
- Trial name
- AffTouch_OB (NCT05768685)
- Testing
- Affective touch paradigm
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Red Cell Survival in Healthy Volunteers
Recovery and Lifespan of Red Blood Cells From Pathogen-reduced, Stored Blood Units
The pilot study has two objectives: 1) to assess the post-infusion viability of INTERCEPT RBC by measuring the 24 hour post-infusion recovery ("PTR24") and lifespan of autologous RBCs prepared with the INTERCEPT System for RBC…
- Trial name
- BIO-CR-RBC (NCT03384407)
- Testing
- Red cell survival in INTERCEPT treated red cells
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Posttraumatic Stress Disorder
Lifespan Integration for Posttraumatic Stress Disorder From an Auto Accident
The purpose of this study is to evaluate if lifespan integration (LI) therapy reduces posttraumatic stress symptoms following a motor vehicle accident (MVA) trauma
- Trial name
- NCT01263067
- Testing
- Lifespan Integration Therapy, Lifespan Integration- Control
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Argosy University
Stress, Physiological, Stress, Psychological
Breath, Stress and Health: a Biocultural Study of Hatha Yoga Practice
This study aims to contribute uniquely to stress, longevity, and mental health research in two ways: by identifying clear protocols of breath-based yoga-meditative practice based on original materials; that are subsequently…
- Trial name
- Yoga (NCT03856892)
- Testing
- High Dose Yoga, Medium Dose Yoga
- Where
- India
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Emory University
Multiple Sclerosis
Immune Response to COVID-19 Vaccine in Multiple Sclerosis Patients Treated With Teriflunomide and Alemtuzumab
Phase IV, 3-armed, prospective, open-label, single-center, Israeli study, examining the response to SARS-CoV-2 vaccination in 30 teriflunomide-, 10 alemtuzumab-treated patients, and 30 age-matched (for the teriflunomide group)…
- Trial name
- NCT05075499
- Testing
- COVID-19 vaccination
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Sheba Medical Center
Dental Restorations Longevity, Dental Restoration Failure
Impact of Patients Risk Factors on the Longevity of Aesthetic Restorations
The objective of this double-blind randomized clinical trial is to evaluate the influence of caries risk, occlusal stress and missing teeth on anterior restorations over a 10 years follow up period.
- Conditions
- Dental Restorations Longevity, Dental Restoration Failure, Esthetics, Dental
- Trial name
- NCT03834636
- Testing
- Restorations with nanoparticulated composites and self etch adhesives, Restorations with nanoparticulated composites and total-etch adhesives, Restorations with nanohybrid composites and self etch adhesives
- Where
- Brazil
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Aging
Deciphering the Factors of Longevity Through a Multi-Omics Study in Long-Lived Individuals in Hong Kong
Population aging is changing societal dynamics and poses significant global challenges. By 2050, an estimated 1.6 billion people worldwide will be over age 65.
- Trial name
- NCT07356700
- Testing
- Observational
- Where
- China
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Hong Kong University of Science and Technology